Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences
Open accessAbstract
Acquisition of the intestinal microbiota begins at birth, and a stable microbial community develops from a succession of key organisms. Disruption of the microbiota during maturation by low-dose antibiotic exposure can alter host metabolism and adiposity. We now show that low-dose penicillin (LDP), delivered from birth, induces metabolic alterations and affects ileal expression of genes involved in immunity. LDP that is limited to early life transiently perturbs the microbiota, which is sufficient to induce sustained effects on body composition, indicating that microbiota interactions in infancy may be critical determinants of long-term host metabolic effects. In addition, LDP enhances the effect of high-fat diet induced obesity. The growth promotion phenotype is transferrable to germ-free hosts by LDP-selected microbiota, showing that the altered microbiota, not antibiotics per se, play a causal role. These studies characterize important variables in early-life microbe-host metabolic interaction and identify several taxa consistently linked with metabolic alterations. PAPERCLIP:
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A causal role for gut microbes in disease is supported in part by fulfillment of one of Koch's postulates: transfer of a disease-related phenotype by transplanting gut microbes into a new host.
“A causal role for the involvement of gut microbes is in part based on the fulfillment of one of Koch’s postulates - namely, the transmission of a disease related phenotype with transplantation of gut microbial organisms to a new host (Cho and Blaser, 2012; Cox et al., 2014; Dumas et al., 2006; Gregory et al., 2015; Koch, 1880; Sandhu and Chase, 1986).”
From Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis (2015) · cites this paper as Cox et al., 2014
The gut microbiome is highly dynamic and adaptable, changing with dietary inputs and with the presence or absence of different diseases.
“Nonetheless, the gut microbiome is known to be remarkably dynamic and adaptive, including changes in response to different dietary inputs, as well as the presence versus absence of distinct diseases (Cox et al., 2014; Koren et al., 2011; Wu et al., 2011).”
From Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis (2015) · cites this paper as Cox et al., 2014
Recent studies by Blaser and colleagues show that affecting microbiota in early windows of critical development can affect metabolism long term.
“Similarly, recent studies by Blaser and colleagues (34) show that affecting microbiota in early windows of critical development can affect metabolism long term.”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [34]
Several taxa transiently disrupted after low-dose penicillin administration at mouse weaning age are linked to persistent metabolic alterations such as enhanced dietary-induced fat mass accumulation and decreased intestinal-based immunity.
“Specifically, they have identified several taxa transiently disrupted after low-dose penicillin administration at mouse weaning age to be linked to persistent metabolic alterations such as enhanced dietary-induced fat mass accumulation and decreased intestinal-based immunity (34).”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [34]
FMT might modulate obesity and metabolism in humans and mice, ameliorate metabolic syndrome in patients, and contribute to the treatment of refractory immune checkpoint inhibitor (ICI)-associated colitis and recurrent infections by Clostridium difficile.
“FMT might modulate obesity and metabolism in humans and mice 29,30 , ameliorate metabolic syndrome in patients 31 , and contribute to the treatment of refractory immune checkpoint inhibitor (ICI)-associated colitis 32 and recurrent infections by Clostridium difficile 33 .”
From Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice (2019) · cites this paper as [30]
Low-dose penicillin causes stronger physiological alterations when started at gestation than at weaning.
“low dose penicillin (LDP) administration was shown to induce stronger physiological alterations if administered from the beginning of gestation, rather than at weaning”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
Early low-dose penicillin decreases expression of intestinal immune genes for RegIIIγ, β-defensins, and IL-17.
“while the expression of intestinal immune genes coding for proteins such asRegIIIγ, β-defensins, and IL-17 was decreased.”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
Early low-dose penicillin increases body mass and fat content in adulthood.
“following early LDP administration, body mass and fat content were increased in adulthood”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [91]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
vegan: Community Ecology Package
Oksanen, J., Simpson, G. L., Blanchet, F. G., Kindt, R., Legendre, P., Minchin, P. R., O’Hara, R. B., Sólymos, P., Stevens, M. H. H., Szöcs, E., et al. (2001) · doi:10.32614/cran.package.vegan · Cited by 27,099 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581 · see citing works
A new method for non-parametric multivariate analysis of variance
Anderson, M. J. (2001) · Austral Ecology · doi:10.1111/j.1442-9993.2001.01070.pp.x · Cited by 13,828 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
Langille, M. G. I., Zaneveld, J., Caporaso, J. G., McDonald, D., Knights, D., Reyes, J. A., Clemente, J. C., Burkepile, D. E., Vega Thurber, R. L., Knight, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2676 · Cited by 9,116 · see citing works
Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms
Caporaso, J. G., Lauber, C. L., Walters, W. A., Berg-Lyons, D., Huntley, J., Fierer, N., Owens, S. M., Betley, J., Fraser, L., Bauer, M., et al. (2012) · The ISME Journal · doi:10.1038/ismej.2012.8 · Cited by 8,839 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
affy—analysis of Affymetrix GeneChip data at the probe level
Gautier, L., Cope, L., Bolstad, B. M., & Irizarry, R. A. (2004) · Bioinformatics · doi:10.1093/bioinformatics/btg405 · Cited by 5,221 · see citing works
McDonald, D. T., Price, M. N., Goodrich, J. K., Nawrocki, E. P., DeSantis, T. Z., Probst, A. J., Andersen, G. L., Knight, R. D., & Hugenholtz, P. (2011) · The ISME Journal · doi:10.1038/ismej.2011.139 · Cited by 5,010 · see citing works
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,906 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Dominguez-Bello, M. G., Costello, E. K., Contreras, M., Magris, M., Hidalgo, G., Fierer, N., & Knight, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002601107 · Cited by 4,774 · see citing works
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Goecks, J., Nekrutenko, A., Taylor, J., & The Galaxy Team (2010) · Genome biology · doi:10.1186/gb-2010-11-8-r86 · Cited by 3,437 · see citing works
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works
Galaxy: a platform for interactive large-scale genome analysis.Preprint
Giardine, B., Riemer, C., Hardison, R., Burhans, R. C., Elnitski, L., Shah, P., Zhang, Y., Blankenberg, D., Albert, I., Taylor, J., et al. (2005) · Genome Research · doi:10.1101/gr.4086505 · Cited by 2,217 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity
Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works
Antibiotics in early life alter the murine colonic microbiome and adiposity
Cho, I., Yamanishi, S., Cox, L., Methé, B. A., Zavadil, J., Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., et al. (2012) · Nature · doi:10.1038/nature11400 · Cited by 1,613 · see citing works
Self-citationSamuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works
Galaxy: A Web‐Based Genome Analysis Tool for Experimentalists
Blankenberg, D. J., Kuster, G. V., Coraor, N., Ananda, G., Lazarus, R. M., Mangan, M. E., Nekrutenko, A., & Taylor, J. (2010) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb1910s89 · Cited by 1,430 · see citing works
HTSeq – A Python framework to work with high-throughput sequencing dataPreprint
Anders, S., Pyl, P. T., & Huber, W. K. (2014) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/002824 · Cited by 1,286 · see citing works
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241 · see citing works
Comparison of Sequencing Utility Programs
Aronesty, E. (2013) · The Open Bioinformatics Journal · doi:10.2174/1875036201307010001 · Cited by 1,144 · see citing works
The influence of sex, handedness, and washing on the diversity of hand surface bacteria
Fierer, N., Hamady, M., Lauber, C. L., & Knight, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807920105 · Cited by 1,100 · see citing works
Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells
Stappenbeck, T. S., Hooper, L. V., & Gordon, J. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202604299 · Cited by 1,095 · see citing works
Critical periods in childhood for the development of obesity
Dietz, W. H. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/59.5.955 · Cited by 1,069 · see citing works
Early differences in fecal microbiota composition in children may predict overweight
Kalliomäki, M. A., Collado, M. C., Salminen, S., & Isolauri, E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.534 · Cited by 1,056 · see citing works
Gender Bias in Autoimmunity Is Influenced by Microbiota
Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 912 · see citing works
Incidence of Childhood Obesity in the United States
Cunningham, S. A., Kramer, M. R., & Narayan, K. M. V. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1309753 · Cited by 723 · see citing works
Reeder, S. B., Pineda, A. R., Wen, Z., Shimakawa, A. S., Yu, H., Brittain, J. H., Gold, G. E., Beaulieu, C. F., & Pelc, N. J. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20624 · Cited by 707 · see citing works
High-fat diet alters gut microbiota physiology in mice
Daniel, H., Gholami, A. M., Berry, D., Desmarchelier, C., Hahne, H., Loh, G., Mondot, S., Lepage, P., Rothballer, M., Walker, A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2013.155 · Cited by 680 · see citing works
Incidence of Childhood Obesity in the United States
Cunningham, S. A., Kramer, M. R., & Narayan, K. M. V. (2014) · New England Journal of Medicine · doi:10.1056/nejmc1402397 · Cited by 669 · see citing works
WHY AND HOW ANTIBIOTICS ARE USED IN SWINE PRODUCTION
Cromwell, G. L. (2002) · Animal Biotechnology · doi:10.1081/abio-120005767 · Cited by 634 · see citing works
The distinction of metabolically ‘healthy’ from ‘unhealthy’ obese individuals
Blüher, M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3283346ccc · Cited by 632 · see citing works
ANTIBIOTICS AS GROWTH PROMOTANTS:MODE OF ACTION
Gaskins, H. R., Collier, C. T., & Anderson, D. B. (2002) · Animal Biotechnology · doi:10.1081/abio-120005768 · Cited by 607 · see citing works
Obesity and cancer risk: evidence, mechanisms, and recommendations
Vučenik, I., & Stains, J. P. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06750.x · Cited by 574 · see citing works
Reproducible Community Dynamics of the Gastrointestinal Microbiota following Antibiotic Perturbation
Antonopoulos, D. A., Huse, S. M., Morrison, H. G., Schmidt, T. M., Sogin, M. L., & Young, V. B. (2009) · Infection and Immunity · doi:10.1128/iai.01520-08 · Cited by 545 · see citing works
Ajslev, T. A., Andersen, C. S., Gamborg, M., Sørensen, T. I. A., & Jess, T. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.27 · Cited by 534 · see citing works
Pettersson, U. S., Waldén, T. B., Carlsson, P., Jansson, L. E., & Phillipson, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046057 · Cited by 521 · see citing works
Multicoil Dixon chemical species separation with an iterative least‐squares estimation method
Reeder, S. B., Wen, Z., Yu, H., Pineda, A. R., Gold, G. E., Markl, M., & Pelc, N. J. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10675 · Cited by 508 · see citing works
Infant antibiotic exposures and early-life body mass
Trasande, L., Blustein, J., Liu, M., Corwin, E. J., Cox, L. M., & Blaser, M. J. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.132 · Cited by 503 · see citing works
Self-citationThe Mode of Growth Promotion by Antibiotics
Visek, W. J. (1978) · Journal of Animal Science · doi:10.2527/jas1978.4651447x · Cited by 476 · see citing works
Million, M., Angelakis, E., Paul, M., Armougom, F., Leibovici, L., & Raoult, D. (2012) · Microbial Pathogenesis · doi:10.1016/j.micpath.2012.05.007 · Cited by 431 · see citing works
Responses of gut microbiota to diet composition and weight loss in lean and obese mice
Ravussin, Y., Koren, O., Spor, A., LeDuc, C., Gutman, R., Stombaugh, J., Knight, R., Ley, R. E., & Leibel, R. L. (2012) · Obesity · doi:10.1038/oby.2011.111 · Cited by 406 · see citing works
Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism
Knittle, J. L., & Hirsch, J. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105894 · Cited by 394 · see citing works
Trends of Outpatient Prescription Drug Utilization in US Children, 2002–2010
Chai, G. P., Governale, L. A., McMahon, A. W., Trinidad, J. P., Staffa, J. A., & Murphy, D. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2879 · Cited by 370 · see citing works
Martínez, I., Wallace, G., Zhang, C., Legge, R. M., Benson, A. K., Carr, T. P., Moriyama, E. N., & Walter, J. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-09 · Cited by 355 · see citing works
THE DEVELOPMENT OF THE BACTERIAL FLORA IN THE GASTROINTESTINAL TRACT OF MICE
Schaedler, R. W., Dubos, R. J., & Costello, R. L. (1965) · The Journal of Experimental Medicine · doi:10.1084/jem.122.1.59 · Cited by 354 · see citing works
Blaser, M. J. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400812 · Cited by 306 · see citing works
Self-citationHuh, S. Y., Rifas‐Shiman, S. L., Zera, C., Edwards, J. R., Oken, E., Weiss, S. T., & Gillman, M. W. (2012) · Archives of Disease in Childhood · doi:10.1136/archdischild-2011-301141 · Cited by 289 · see citing works
Pathways in Microbe-Induced Obesity
Cox, L. M., & Blaser, M. J. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.004 · Cited by 266 · see citing works
Self-citationCoates, M. E., Fuller, R., Harrison, G. F., Lev, M., & Suffolk, S. F. (1963) · British Journal Of Nutrition · doi:10.1079/bjn19630015 · Cited by 262 · see citing works
Association of caesarean delivery with child adiposity from age 6 weeks to 15 years
Blustein, J., Attina, T., Liu, M., Ryan, A. M., Cox, L. M., Blaser, M. J., & Trasande, L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.49 · Cited by 211 · see citing works
Self-citationMurphy, R., Stewart, A. W., Braithwaite, I. E., Beasley, R. W., Hancox, R. J., Mitchell, E. A., & the ISAAC Phase Three Study Group (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.218 · Cited by 169 · see citing works
Ectopic fat accumulation and metabolic syndrome
Rasouli, N., Molavi, B., Elbein, S. C., & Kern, P. A. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00590.x · Cited by 164 · see citing works
Biphasic assembly of the murine intestinal microbiota during early development
Pantoja-Feliciano, I. G., Clemente, J. C., Costello, E. K., Pérez, M.-E., Blaser, M. J., Knight, R. D., & Domínguez-Bello, M. G. (2013) · The ISME Journal · doi:10.1038/ismej.2013.15 · Cited by 152 · see citing works
Self-citationJiang, H.-Q., Bos, N. A., & Cebra, J. J. (2001) · Infection and Immunity · doi:10.1128/iai.69.6.3611-3617.2001 · Cited by 125 · see citing works
Differences in antibiotic prescribing in paediatric outpatients
Clavenna, A., & Bonati, M. R. (2011) · Archives of Disease in Childhood · doi:10.1136/adc.2010.183541 · Cited by 124 · see citing works
Allobaculum stercoricanis gen. nov., sp. nov., isolated from canine feces
Greetham, H. L., Gibson, G. R., Giffard, C. J., Hippe, H., Merkhoffer, B., Steiner, U., Falsen, E., & Collins, M. D. (2004) · Anaerobe · doi:10.1016/j.anaerobe.2004.06.004 · Cited by 114 · see citing works
Morrison, C. D., Huypens, P., Stewart, L. K., & Gettys, T. W. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.09.005 · Cited by 80 · see citing works
Karlsson, C., Molin, G., Fåk, F., Hagslätt, M.-L. J., Jakesevic, M., Håkansson, Å., Jeppsson, B. W., Weström, B. R., & Ahrné, S. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001036 · Cited by 73 · see citing works
Resident commensals shaping immunity
Ertürk-Hasdemir, D., & Kasper, D. L. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.06.001 · Cited by 67 · see citing works
THE EFFECT OF ANTIBACTERIAL DRUGS ON THE WEIGHT OF MICE
Dubos, R. J., Schaedler, R. W., & Costello, R. L. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.117.2.245 · Cited by 42 · see citing works
Collins, M. D., Shah, H. N., & MITSUOKA, T. (1985) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(85)80015-1 · Cited by 41 · see citing works
Davis, C. P., & Savage, D. C. (1976) · Infection and Immunity · doi:10.1128/iai.13.1.180-188.1976 · Cited by 39 · see citing works
Antunes, L. C. M., & Finlay, B. B. (2011) · Gut Microbes · doi:10.4161/gmic.2.2.15610 · Cited by 35 · see citing works
The role of peptide YY in integrative gut physiology and potential role in obesity
Grudell, A., & Camilleri, M. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3280123119 · Cited by 27 · see citing works
Fat and Water 1H MRI to Investigate Effects of Leptin in Obese Mice
James, J. R., Hertel, J. L., Babsky, A. M., Hekmatyar, S. K., Heiman, M. L., Jackson, C. V., & Bansal, N. (2009) · Obesity · doi:10.1038/oby.2009.133 · Cited by 8 · see citing works
A Comprehensive Insight into The Development of Animal Models For Obesity Research.
Goyal, A. (2012) · Global Journal of Medical Research · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report
Malfertheiner, P., Mégraud, F., O'Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T. R., Bazzoli, F., Gasbarrini, A., Atherton, J. C., Graham, D. Y., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312288 · Cited by 2,969 · see citing works
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature · doi:10.1038/nature14232 · Cited by 2,055 · see citing works
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968 · see citing works
Management of Helicobacter pylori infection: the Maastricht VI/Florence consensus report
Malfertheiner, P., Mégraud, F., Rokkas, T., Gisbert, J. P., Liou, J., Schulz, C., Gasbarrini, A., Hunt, R. H., Leja, M., O'Morain, C. A., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327745 · Cited by 1,674 · see citing works
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469 · see citing works
Self-citationGut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503 · see citing works
Salt-responsive gut commensal modulates TH17 axis and disease
Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., et al. (2017) · Nature · doi:10.1038/nature24628 · Cited by 1,310 · see citing works
The composition of the gut microbiota throughout life, with an emphasis on early life
Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works
Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.055 · Cited by 1,317 · see citing works
Ben, Y., Fu, C., Hu, M., Liu, L., Wong, M. H., & Zheng, C. (2018) · Environmental Research · doi:10.1016/j.envres.2018.11.040 · Cited by 1,277 · see citing works
The microbiome in early life: Implications for health outcomes
Tamburini, S., Shen, N., Wu, H. C., & Clemente, J. C. (2016) · Nature Medicine · doi:10.1038/nm.4142 · Cited by 1,213 · see citing works
Kostic, A. D., Gevers, D., Siljander, H., Vatanen, T., Hyötyläinen, T., Hämäläinen, A., Peet, A., Tillmann, V., Pöhö, P., Mattila, I. M., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.001 · Cited by 1,165 · see citing works
Collado, M. C., Rautava, S., Aakko, J., Isolauri, E., & Salminen, S. (2016) · Scientific Reports · doi:10.1038/srep23129 · Cited by 1,098 · see citing works
Yassour, M., Vatanen, T., Siljander, H., Hämäläinen, A.-M., Härkönen, T., Ryhänen, S. J., Franzosa, E. A., Vlamakis, H., Huttenhower, C., Gevers, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0917 · Cited by 1,043 · see citing works
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works
Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer
Dominguez-Bello, M. G., De Jesus-Laboy, K. M., Shen, N., Cox, L. M., Amir, A., Gonzalez, A., Bokulich, N. A., Song, S. J., Hoashi, M., Rivera-Vinas, J. I., et al. (2016) · Nature Medicine · doi:10.1038/nm.4039 · Cited by 1,014 · see citing works
Self-citationThe role of the gut microbiota in NAFLD
Leung, C., Rivera, L., Furness, J. B., & Angus, P. W. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.85 · Cited by 1,020 · see citing works
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life
Takiishi, T., Fenero, C. I. M., & Câmara, N. O. S. (2017) · Tissue Barriers · doi:10.1080/21688370.2017.1373208 · Cited by 1,009 · see citing works
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
Becattini, S., Taur, Y., & Pamer, E. G. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.04.003 · Cited by 901 · see citing works
The infant microbiome development: Mom matters
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943 · see citing works
Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health
Serwecińska, L. (2020) · Water · doi:10.3390/w12123313 · Cited by 852 · see citing works
The microbiome of uncontacted Amerindians
Clemente, J. C., Pehrsson, E. C., Blaser, M. J., Sandhu, K., Gao, Z., Wang, B., Magris, M., Hidalgo, G., Contreras, M., Noya-Alarcón, Ó., et al. (2015) · Science Advances · doi:10.1126/sciadv.1500183 · Cited by 851 · see citing works
Self-citationMicrobiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works
Antibiotic use and its consequences for the normal microbiome
Blaser, M. J. (2016) · Science · doi:10.1126/science.aad9358 · Cited by 836 · see citing works
Self-citationGadde, U., Kim, W. H., Oh, S., & Lillehoj, H. S. (2017) · Animal Health Research Reviews · doi:10.1017/s1466252316000207 · Cited by 802 · see citing works
Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour
Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760 · see citing works
Impact of antibiotics on the human microbiome and consequences for host health
Patangia, D. V., Ryan, C. A., Dempsey, E. M., Ross, R. P., & Stanton, C. (2022) · MicrobiologyOpen · doi:10.1002/mbo3.1260 · Cited by 806 · see citing works
Gut microbiota induce IGF-1 and promote bone formation and growth
Yan, J., Herzog, J. W., Tsang, K., Brennan, C. A., Bower, M. A., Garrett, W. S., Sartor, B. R., Aliprantis, A. O., & Charles, J. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607235113 · Cited by 750 · see citing works
Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children
Korpela, K., Salonen, A., Virta, L. J., Kekkonen, R. A., Forslund, K., Bork, P., & de Vos, W. M. (2016) · Nature Communications · doi:10.1038/ncomms10410 · Cited by 698 · see citing works
Effects of environmental pollutants on gut microbiota
Jin, Y., Wu, S., Zeng, Z., & Fu, Z. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2016.11.045 · Cited by 657 · see citing works
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
Bárcena, C., Valdés-Mas, R., Mayoral, P., Garabaya, C., Durand, S., Rodríguez, F., Fernández-García, M. T., Salazar, N., Nogacka, A. M., Garatachea, N., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0504-5 · Cited by 661 · see citing works
Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome
Sze, M. A., & Schloss, P. D. (2016) · mBio · doi:10.1128/mbio.01018-16 · Cited by 600 · see citing works
Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults
Stoffel, E. M., & Murphy, C. C. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.07.055 · Cited by 655 · see citing works
Maturation of the gut microbiome and risk of asthma in childhood
Stokholm, J., Blaser, M. J., Thorsen, J., Rasmussen, M. A., Waage, J., Vinding, R. K., Schoos, A.-M. M., Kunøe, A., Fink, N. R., Chawes, B. L., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02573-2 · Cited by 614 · see citing works
Self-citationEngineering Microbiomes to Improve Plant and Animal Health
Mueller, U. G., & Sachs, J. L. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.07.009 · Cited by 628 · see citing works
Antibiotics as deep modulators of gut microbiota: between good and evil
Ianiro, G., Tilg, H., & Gasbarrini, A. (2016) · Gut · doi:10.1136/gutjnl-2016-312297 · Cited by 629 · see citing works
Natural Products as Platforms To Overcome Antibiotic Resistance
Rossiter, S. E., Fletcher, M. H., & Wuest, W. M. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00283 · Cited by 622 · see citing works
Azad, M. B., Konya, T., Persaud, R. R., Guttman, D. S., Chari, R., Field, C. J., Sears, M., Mandhane, P., Turvey, S., Subbarao, P., et al. (2015) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13601 · Cited by 619 · see citing works
The microbiota-gut-brain axis in obesity.
Torres-Fuentes, C., Schellekens, H., Dinan, T., & Cryan, J. (2017) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 506 · see citing works
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition
Schwarzer, M., Makki, K., Storelli, G., Machuca‐Gayet, I., Šrůtková, D., Hermanová, P. P., Martino, M. E., Balmand, S., Hudcovic, T., Heddi, A., et al. (2016) · Science · doi:10.1126/science.aad8588 · Cited by 590 · see citing works
Chassaing, B., Van de Wiele, T., De Bodt, J., Marzorati, M., & Gewirtz, A. T. (2017) · Gut · doi:10.1136/gutjnl-2016-313099 · Cited by 590 · see citing works
A wave of regulatory T cells into neonatal skin mediates tolerance to commensal microbes
Scharschmidt, T. C., Vasquez, K. S., Truong, H.-A., Gearty, S. V., Pauli, M. L., Nosbaum, A., Gratz, I. K., Otto, M., Moon, J. J., Liese, J., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.016 · Cited by 586 · see citing works
Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort
Hill, C. J., Lynch, D. B., Murphy, K., Ulaszewska, M., Jeffery, I. B., O’Shea, C. A., Watkins, C., Dempsey, E., Mattivi, F., Tuohy, K., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0213-y · Cited by 573 · see citing works
Interaction of gut microbiota with bile acid metabolism and its influence on disease states
Staley, C. M., Weingarden, A. R., Khoruts, A., & Sadowsky, M. J. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-8006-6 · Cited by 582 · see citing works
The gut microbiota influences skeletal muscle mass and function in mice
Lahiri, S., Kim, H., Garcia-Perez, I., Reza, M. M., Martin, K. A., Kundu, P., Cox, L. M., Selkrig, J., Posma, J. M., Zhang, H., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5662 · Cited by 580 · see citing works
Self-citationZarrinpar, A., Chaix, A., Xu, Z. Z., Chang, M. W., Marotz, C. A., Saghatelian, A., Knight, R., & Panda, S. (2018) · Nature Communications · doi:10.1038/s41467-018-05336-9 · Cited by 546 · see citing works
Antibiotics in early life and obesity
Cox, L. M., & Blaser, M. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.210 · Cited by 543 · see citing works
Self-citationUssar, S., Griffin, N. W., Bézy, O., Fujisaka, S., Vienberg, S. G., Softic, S., Deng, L., Bry, L., Gordon, J. I., & Kahn, C. R. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.007 · Cited by 529 · see citing works
Antibiotics, Pediatric Dysbiosis, and Disease
Vangay, P., Ward, T., Gerber, J. S., & Knights, D. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.006 · Cited by 531 · see citing works
The Intestinal Microbiome and Estrogen Receptor–Positive Female Breast Cancer
Kwa, M. J., Plottel, C. S., Blaser, M. J., & Adams, S. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw029 · Cited by 530 · see citing works
Self-citationThe ancestral and industrialized gut microbiota and implications for human health
Sonnenburg, E. D., & Sonnenburg, J. L. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0191-8 · Cited by 489 · see citing works
Gérard, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2061-5 · Cited by 512 · see citing works
Sleep, circadian rhythm, and gut microbiota
Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495 · see citing works
Association of Antibiotics in Infancy With Early Childhood Obesity
Bailey, L. C., Forrest, C. B., Zhang, P., Richards, T. M., Livshits, A., & DeRusso, P. A. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2014.1539 · Cited by 488 · see citing works
Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation
Gregory, J. C., Buffa, J. A., Org, E., Wang, Z., Levison, B. S., Zhu, W., Wagner, M. A., Bennett, B. J., Li, L., DiDonato, J. A., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.618249 · Cited by 486 · see citing works
Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice
Kimura, I., Miyamoto, J., Ohue‐Kitano, R., Watanabe, K., Yamada, T., Onuki, M., Aoki, R., Isobe, Y., Kashihara, D., Inoue, D., et al. (2020) · Science · doi:10.1126/science.aaw8429 · Cited by 488 · see citing works
The Intestinal Immune System in Obesity and Insulin Resistance
Winer, D. A., Luck, H., Tsai, S. J., & Winer, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.003 · Cited by 476 · see citing works
Mother’s Milk: A purposeful contribution to the development of the infant microbiota and immunity
Le Doare, K., Holder, B., Bassett, A., & Pannaraj, P. S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00361 · Cited by 475 · see citing works
Developmental trajectory of the healthy human gut microbiota during the first 5 years of life
Roswall, J., Olsson, L. M., Kovatcheva‐Datchary, P., Nilsson, S., Tremaroli, V., Simon, M., Kiilerich, P., Akrami, R., Kramer, M. M., Uhlén, M., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.02.021 · Cited by 473 · see citing works
Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny
Kollmann, T. R., Kampmann, B., Mazmanian, S. K., Marchant, A., & Levy, O. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.009 · Cited by 478 · see citing works
The gut microbiota in human energy homeostasis and obesity
Rosenbaum, M., Knight, R., & Leibel, R. L. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.07.002 · Cited by 450 · see citing works
Menstruation: science and society
Critchley, H., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M. D., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 484 · see citing works
Leclercq, S., Mian, F. M., Stanisz, A. M., Bindels, L. B., Cambier, E., Ben-Amram, H., Koren, O., Forsythe, P., & Bienenstock, J. (2017) · Nature Communications · doi:10.1038/ncomms15062 · Cited by 434 · see citing works
Research progress in the relationship between type 2 diabetes mellitus and intestinal flora
Ma, Q., Li, Y., Li, P., Wang, M., Wang, J., Tang, Z., Wang, T., Luo, L., Wang, C., Wang, T., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109138 · Cited by 436 · see citing works
Role of priority effects in the early-life assembly of the gut microbiota
Sprockett, D., Fukami, T., & Relman, D. A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.173 · Cited by 419 · see citing works
Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes
Li, W., & Duffy, A. J. (2017) · Journal of Nutrition · doi:10.3945/jn.116.240754 · Cited by 419 · see citing works
The gut-bone axis: How bacterial metabolites bridge the distance
Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403 · see citing works
Flandroy, L., Poutahidis, T., Berg, G., Clarke, G. A., Dao, M. C., Decaestecker, E., Furman, E., Haahtela, T., Massart, S., Plovier, H., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.01.288 · Cited by 399 · see citing works
Unravelling the collateral damage of antibiotics on gut bacteria
Maier, L., Goemans, C., Wirbel, J., Kuhn, M., Eberl, C., Pruteanu, M., Müller, P., García‐Santamarina, S., Cacace, E., Zhang, B., et al. (2021) · Nature · doi:10.1038/s41586-021-03986-2 · Cited by 388 · see citing works
Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
Laukens, D., Brinkman, B. M. N., Raes, J., Vos, M. D., & Vandenabeele, P. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv036 · Cited by 378 · see citing works
Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment
Nobel, Y. R., Cox, L. M., Kirigin, F. F., Bokulich, N. A., Yamanishi, S., Teitler, I., Chung, J., Sohn, J., Barber, C. M., Goldfarb, D. S., et al. (2015) · Nature Communications · doi:10.1038/ncomms8486 · Cited by 377 · see citing works
Self-citationA key genetic factor for fucosyllactose utilization affects infant gut microbiota development
Matsuki, T., Yahagi, K., Mori, H., Matsumoto, H., Hara, T., Tajima, S., Ogawa, E., Kodama, H., Yamamoto, K., Yamada, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms11939 · Cited by 375 · see citing works
An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
Gonzalez, F. J., Jiang, C., & Patterson, A. D. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.08.057 · Cited by 377 · see citing works
Hänninen, A., Toivonen, R., Pöysti, S., Belzer, C., Plovier, H., Ouwerkerk, J. P., Emani, R., Cani, P. D., & De Vos, W. M. (2018) · Gut · doi:10.1136/gutjnl-2017-314508 · Cited by 359 · see citing works
Thomas, S., Izard, J., Walsh, E. K., Batich, K. A., Chongsathidkiet, P., Clarke, G. A., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 369 · see citing works
Antibiotic Exposure in Infancy and Risk of Being Overweight in the First 24 Months of Life
Saari, A., Virta, L. J., Sankilampi, U., Dunkel, L., & Saxén, H. (2015) · PEDIATRICS · doi:10.1542/peds.2014-3407 · Cited by 364 · see citing works
Gut microbiota: a new path to treat obesity
Muscogiuri, G., Cantone, E., Cassarano, S., Tuccinardi, D., Barrea, L., Savastano, S., & Colao, A. (2019) · International Journal of Obesity Supplements · doi:10.1038/s41367-019-0011-7 · Cited by 360 · see citing works
Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
Livanos, A. E., Greiner, T. U., Vangay, P., Pathmasiri, W., Stewart, D. A., McRitchie, S., Li, H., Chung, J., Sohn, J., Kim, S. S., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.140 · Cited by 357 · see citing works
Self-citationThe Role of the Microbiome in the Developmental Origins of Health and Disease
Stiemsma, L. T., & Michels, K. B. (2018) · PEDIATRICS · doi:10.1542/peds.2017-2437 · Cited by 357 · see citing works
Dahiya, D. K., Renuka, Puniya, M., Shandilya, U. K., Dhewa, T., Kumar, N., Kumar, S., Puniya, A. K., & Shukla, P. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00563 · Cited by 357 · see citing works
Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?
Houghteling, P. D., & Walker, W. A. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000597 · Cited by 342 · see citing works
Dogra, S. K., Sakwińska, O., Soh, S., Ngom‐Bru, C., Brück, W. M., Berger, B. W., Brüssow, H., Lee, Y. S., Yap, F. K. P., Chong, Y. S., et al. (2015) · mBio · doi:10.1128/mbio.02419-14 · Cited by 348 · see citing works
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.013 · Cited by 333 · see citing works
Prescott, S. L., Larcombe, D.-L., Logan, A. C., West, C., Burks, W., Caraballo, L., Levin, M., Etten, E. V., Horwitz, P., Kozyrskyj, A., et al. (2017) · World Allergy Organization Journal · doi:10.1186/s40413-017-0160-5 · Cited by 347 · see citing works
The Association between Early-Life Gut Microbiota and Long-Term Health and Diseases
Sarkar, A., Yoo, J. Y., Dutra, S. V. O., Morgan, K. H., & Groer, M. E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030459 · Cited by 346 · see citing works
The chicken gut metagenome and the modulatory effects of plant-derived benzylisoquinoline alkaloids
Huang, P., Zhang, Y., Xiao, K., Jiang, F., Wang, H., Tang, D., Liu, D., Liu, B., Liu, Y., He, X., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0590-5 · Cited by 339 · see citing works
Yu, E. W.-Y., Gao, L., Stastka, P., Cheney, M. C., Mahabamunuge, J., Soto, M. T., Ford, C. B., Bryant, J. A., Henn, M. R., & Hohmann, E. L. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003051 · Cited by 336 · see citing works
Vulnerability of the industrialized microbiota
Sonnenburg, J. L., & Sonnenburg, E. D. (2019) · Science · doi:10.1126/science.aaw9255 · Cited by 330 · see citing works
Jašarević, E., Howerton, C. L., Howard, C. D., & Bale, T. L. (2015) · Endocrinology · doi:10.1210/en.2015-1177 · Cited by 329 · see citing works
Luna, R. A., & Foster, J. A. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.007 · Cited by 325 · see citing works
The Role of the Immune System in Metabolic Health and Disease
Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323 · see citing works
Tsukuda, N., Yahagi, K., Hara, T., Watanabe, Y., Matsumoto, H., Mori, H., Higashi, K., Tsuji, H., Matsumoto, S., Kurokawa, K., et al. (2021) · The ISME Journal · doi:10.1038/s41396-021-00937-7 · Cited by 324 · see citing works
The gut microbiota in obesity and weight management: microbes as friends or foe?
Hul, M. V., & Cani, P. D. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00794-0 · Cited by 335 · see citing works
Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist
Spaulding, C. N., Klein, R. D., Ruer, S., Kau, A. L., Schreiber, H. L., Cusumano, Z., Dodson, K., Pinkner, J. S., Fremont, D. H., Janetka, J. W., et al. (2017) · Nature · doi:10.1038/nature22972 · Cited by 319 · see citing works
The Gut Microbiota at the Service of Immunometabolism
Michaudel, C., & Sokol, H. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.004 · Cited by 321 · see citing works
Management of Infants at Risk for Group B Streptococcal Disease
Puopolo, K. M., Lynfield, R., Cummings, J. J., Hand, I. L., Adams-Chapman, I. S., Poindexter, B. B., Stewart, D. L., Aucott, S. W., Goldsmith, J. P., Mowitz, M. E., et al. (2019) · PEDIATRICS · doi:10.1542/peds.2019-1881 · Cited by 318 · see citing works
Gut Microbiota, Immune System, and Bone
D’Amelio, P., & Sassi, F. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0331-y · Cited by 315 · see citing works
Gasparrini, A. J., Wang, B., Sun, X., Kennedy, E. A., Hernandez-Leyva, A. J., Ndao, I. M., Tarr, P. I., Warner, B. B., & Dantas, G. A. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0550-2 · Cited by 305 · see citing works
Heiss, C. N., & Olofsson, L. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12684 · Cited by 304 · see citing works
- Authors
- Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., Zárate Rodriguez, J. G., Rogers, A. B., Robine, N., Loke, P., & Blaser, M. J.
- Affiliations
- NYU Langone Health (US)
- Tufts University (US)
- New York Genome Center (US)
- VA NY Harbor Healthcare System (US)
- Corresponding author
- Blaser, Martin J.
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 158
- Issue
- 4
- Pages
- 705-721
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC4134513
- OpenAlex
- W2053039168
- Cited by
- 1,859
- References
- 81
- Citations by year
- 2026: 74 · 2025: 119 · 2024: 137 · 2023: 145 · 2022: 177 · 2021: 194 · 2020: 182 · 2019: 163 · 2018: 182 · 2017: 177 · 2016: 161 · 2015: 124 · 2014: 20
- FWCI
- 65.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- Funders
- NYU Langone Medical Center
- New York Genome Center
- National Institutes of Health
- National Cancer Institute (P30CA016087)
- National Institute of Allergy and Infectious Diseases (R01AI093811)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090989)
- National Center for Research Resources (UL1RR029893)
- Argonne National Laboratory
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, early-life antibiotic exposure, microbiota disruption, body composition, obesity, high-fat diet, ileal gene expression, immunity, germ-free mice, host-microbe metabolic interactions, developmental programming
- MeSH terms
- Animals, Anti-Bacterial Agents, Bacteria, Disease Models, Animal, Female, Intestinal Mucosa, Intestines, Male, Mice, Inbred C57BL, Obesity, Penicillins, Mice, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
