Metacaspases

A Caspase-Related Protease Regulates Apoptosis in Yeast

Madeo, F., Herker, E., Maldener, C., Wissing, S., Lächelt, S., Herlan, M., Fehr, M., Lauber, K., Sigrist, S. J., Wesselborg, S., et al. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00501-4 · Cited by 872

Structural Basis for the Inhibition of Caspase-3 by XIAP

Riedl, S. J., Renatus, M., Schwarzenbacher, R., Zhou, Q., Sun, C., Fesik, S. W., Liddington, R. C., & Salvesen, G. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00274-4 · Cited by 792

The Involvement of Cysteine Proteases and Protease Inhibitor Genes in the Regulation of Programmed Cell Death in Plants

Solomon, M., Belenghi, B., Delledonne, M., Menachem, E., & Levine, A. (1999) · The Plant Cell · doi:10.1105/tpc.11.3.431 · Cited by 760

Human Caspases: Activation, Specificity, and Regulation

Pop, C., & Salvesen, G. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800084200 · Cited by 754

Chronological aging leads to apoptosis in yeast

Herker, E., Jungwirth, H., Lehmann, K. A., Maldener, C., Fröhlich, K.-U., Wissing, S., Büttner, S., Fehr, M., Sigrist, S., & Madeo, F. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310014 · Cited by 548

A micrococcal nuclease homologue in RNAi effector complexes

Caudy, A. A., Ketting, R. F., Hammond, S. M., Denli, A. M., Bathoorn, A. M. P., Tops, B. B. J., Silva, J. M., Myers, M. M., Hannon, G. J., & Plasterk, R. H. A. (2003) · Nature · doi:10.1038/nature01956 · Cited by 473

Identification of Paracaspases and Metacaspases Two Ancient Families of Caspase-like Proteins, One of which Plays a Key Role in MALT Lymphoma

Uren, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00094-0 · Cited by 459

Arabidopsis Type I Metacaspases Control Cell Death

Coll, N. S., Vercammen, D., Smidler, A., Clover, C., Van Breusegem, F., Dangl, J. L., & Epple, P. (2010) · Science · doi:10.1126/science.1194980 · Cited by 425

Type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana Cleave Substrates after Arginine and Lysine

Vercammen, D., van de Cotte, B., Jaeger, G. D., Eeckhout, D., Casteels, P., Vandepoele, K., Vandenberghe, I. H. M., BEEUMEN, J. V., Inzé, D., & Breusegem, F. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406329200 · Cited by 357

Purification and Characterization of Serine Proteases That Exhibit Caspase-Like Activity and Are Associated with Programmed Cell Death in Avena sativa

Coffeen, W. C., & Wolpert, T. J. (2004) · The Plant Cell · doi:10.1105/tpc.017947 · Cited by 274

Two Arabidopsis Metacaspases AtMCP1b and AtMCP2b Are Arginine/Lysine-specific Cysteine Proteases and Activate Apoptosis-like Cell Death in Yeast

Watanabe, N., & Lam, E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413527200 · Cited by 264

Cysteine protease mcII-Pa executes programmed cell death during plant embryogenesis

Bozhkov, P. V., Suarez, M. F., Filonova, L. H., Daniel, G., Zamyatnin, A. A., Rodriguez-Nieto, S., Zhivotovsky, B., & Smertenko, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506948102 · Cited by 256

Metacaspase Activity of Arabidopsis thaliana Is Regulated by S-Nitrosylation of a Critical Cysteine Residue

Belenghi, B., Romero-Puertas, M. C., Vercammen, D., Brackenier, A., Inzé, D., Delledonne, M., & Van Breusegem, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608931200 · Cited by 232

Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome

Sundström, J. F., Vaculova, A., Smertenko, A. P., Savenkov, E. I., Golovko, A., Minina, E., Tiwari, B. S., Rodriguez-Nieto, S., Zamyatnin, A. A., Välineva, T., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1979 · Cited by 212

Serpin1 of Arabidopsis thaliana is a Suicide Inhibitor for Metacaspase 9

Vercammen, D., Belenghi, B., van de Cotte, B., Beunens, T., Gavigan, J.-A., Rycke, R. M. D., Brackenier, A., Inzé, D., Harris, J. L., & Breusegem, F. V. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.09.010 · Cited by 197

Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia

Váchová, L., & Palková, Z. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410064 · Cited by 194

Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II

Yang, J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf463 · Cited by 190

Are metacaspases caspases?

Vercammen, D., Declercq, W., Vandenabeele, P., & Van Breusegem, F. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705193 · Cited by 188

Classification of the caspase–hemoglobinase fold: Detection of new families and implications for the origin of the eukaryotic separins

Aravind, L., & Koonin, E. V. (2002) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.10060 · Cited by 185

Viral activation and recruitment of metacaspases in the unicellular coccolithophore, Emiliania huxleyi

Bidle, K. D., Haramaty, L., Barcelos e Ramos, J., & Falkowski, P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701240104 · Cited by 183

Arabidopsis metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses

Watanabe, N., & Lam, E. (2011) · The Plant Journal · doi:10.1111/j.1365-313x.2011.04554.x · Cited by 170

Metacaspase Yca1 is required for clearance of insoluble protein aggregates

Lee, R. E. C., Brunette, S., Puente, L. G., & Megeney, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006610107 · Cited by 164

VEIDase is a principal caspase-like activity involved in plant programmed cell death and essential for embryonic pattern formation

Bozhkov, P. V., Filonova, L. H., Suárez, M. F., Helmersson, A., Smertenko, A., Zhivotovsky, B., & von Arnold, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401330 · Cited by 159

Caspase-dependent and caspase-independent cell death pathways in yeast

Madeo, F., Carmona‐Gutiérrez, D., Ring, J., Büttner, S., Eisenberg, T., & Kroemer, G. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.117 · Cited by 148

A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae

Szallies, A., Kubata, B. K., & Duszenko, M. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02608-x · Cited by 141

Structural and kinetic determinants of protease substrates

Timmer, J. C., Zhu, W., Pop, C., Regan, T. W., Snipas, S. J., Eroshkin, A. M., Riedl, S. J., & Salvesen, G. S. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1668 · Cited by 136

Characterization of Metacaspases with Trypsin-Like Activity and Their Putative Role in Programmed Cell Death in the Protozoan Parasite Leishmania

Lee, N., Gannavaram, S., Selvapandiyan, A., & Debrabant, A. (2007) · Eukaryotic Cell · doi:10.1128/ec.00123-07 · Cited by 135

Iron Starvation and Culture Age Activate Metacaspases and Programmed Cell Death in the Marine Diatom Thalassiosira pseudonana

Bidle, K. D., & Bender, S. J. (2007) · Eukaryotic Cell · doi:10.1128/ec.00296-07 · Cited by 132

Plagiochin E, an antifungal active macrocyclic bis(bibenzyl), induced apoptosis in Candida albicans through a metacaspase-dependent apoptotic pathway

Wu, X., Chang, W., Cheng, A., Sun, L., & Lou, H. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2010.01.001 · Cited by 130

Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome

Yang, J., Välineva, T., Hong, J., Bu, T., Yao, Z., Jensen, O. N., Frilander, M. J., & Silvennoinen, O. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm470 · Cited by 124

An essential role for the Leishmania major metacaspase in cell cycle progression

Ambit, A., Fasel, N. J., Coombs, G. H., & Mottram, J. C. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402232 · Cited by 120

Multiple Signaling Pathways Regulate Yeast Cell Death during the Response to Mating Pheromones

Zhang, N.-N., Dudgeon, D. D., Paliwal, S., Levchenko, A., Grote, E., & Cunningham, K. W. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-03-0177 · Cited by 117

Bloodstream formTrypanosoma bruceidepend upon multiple metacaspases associated with RAB11-positive endosomes

Helms, M. J., Ambit, A., Appleton, P. L., Tetley, L., Coombs, G. H., & Mottram, J. C. (2006) · Journal of Cell Science · doi:10.1242/jcs.02809 · Cited by 113

The RNA Binding Protein Tudor-SN Is Essential for Stress Tolerance and Stabilizes Levels of Stress-Responsive mRNAs Encoding Secreted Proteins in Arabidopsis

Frey, N. F. D., Müller, P., Jammes, F., Kizis, D., Leung, J., Perrot‐Rechenmann, C., & Bianchi, M. W. (2010) · The Plant Cell · doi:10.1105/tpc.109.070680 · Cited by 103

A Non-Death Role of the Yeast Metacaspase: Yca1p Alters Cell Cycle Dynamics

Lee, R., Puente, L. G., Kærn, M., & Megeney, L. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002956 · Cited by 102

Calcium-dependent Activation and Autolysis of Arabidopsis Metacaspase 2d

Watanabe, N., & Lam, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.194340 · Cited by 97

Viruses activate a genetically conserved cell death pathway in a unicellular organism

Ivanovska, I., & Hardwick, J. M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503069 · Cited by 96

Candida albicans cells lacking CaMCA1-encoded metacaspase show resistance to oxidative stress-induced death and change in energy metabolism

Cao, Y., Huang, S., Dai, B., Zhu, Z., Lu, H., Dong, L., Cao, Y., Wang, Y., Gao, P., Chai, Y., et al. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.11.001 · Cited by 94

Metacaspase 2 of Trypanosoma brucei is a calcium‐dependent cysteine peptidase active without processing

Moss, C., Westrop, G. D., Juliano, L., Coombs, G. H., & Mottram, J. C. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.009 · Cited by 93

The Aspergillus fumigatus metacaspases CasA and CasB facilitate growth under conditions of endoplasmic reticulum stress

Richie, D. L., Miley, M. D., Bhabhra, R., Robson, G. D., Rhodes, J. C., & Askew, D. S. (2006) · Molecular Microbiology · doi:10.1111/j.1365-2958.2006.05534.x · Cited by 93

YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase‐like activity

Guaragnella, N., Pereira, C., Sousa, M. J., Antonacci, L., Passarella, S., Côrte‐Real, M., Marra, E., & Giannattasio, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.11.050 · Cited by 88

Metacaspases are caspases. Doubt no more

Carmona‐Gutiérrez, D., Fröhlich, K.-U., Kroemer, G., & Madeo, F. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2009.198 · Cited by 87

Deletion of putative apoptosis factors leads to lifespan extension in the fungal ageing model Podospora anserina

Hamann, A., Brust, D., & Osiewacz, H. D. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05839.x · Cited by 86

The multifunctional human p100 protein 'hooks' methylated ligands

Shaw, N., Zhao, M., Cheng, C., Xu, H., Saarikettu, J., Li, Y., Da, Y., Yao, Z., Silvennoinen, O., Yang, J., et al. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1269 · Cited by 85

Yeast Lacking theSRO7/SOP1-encoded Tumor Suppressor Homologue Show Increased Susceptibility to Apoptosis-like Cell Death on Exposure to NaCl Stress

Wadskog, I., Maldener, C., Proksch, A., Madeo, F., & Adler, L. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-02-0114 · Cited by 83

Inosine-Containing dsRNA Binds a Stress-Granule-like Complex and Downregulates Gene Expression In trans

Scadden, A. D. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.005 · Cited by 79

Methods for the proteomic identification of protease substrates

Agard, N. J., & Wells, J. A. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.07.026 · Cited by 72

Molecular Characterization of Propolis-Induced Cell Death in Saccharomyces cerevisiae

de Castro, P. A., Savoldi, M., Bonatto, D., de Barros, M. H., Goldman, M. H. S., Berretta, A. A., & Goldman, G. H. (2010) · Eukaryotic Cell · doi:10.1128/ec.00256-10 · Cited by 69

MS‐driven protease substrate degradomics

Impens, F., Colaert, N., Helsens, K., Plasman, K., Damme, P. V., Vandekerckhove, J. S., & Gevaert, K. (2010) · PROTEOMICS · doi:10.1002/pmic.200900418 · Cited by 62

Yeast acetic acid‐induced programmed cell death can occur without cytochrome c release which requires metacaspase YCA1

Guaragnella, N., Bobba, A., Passarella, S., Marra, E., & Giannattasio, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.11.072 · Cited by 53

Bre1p-mediated histone H2B ubiquitylation regulates apoptosis in Saccharomyces cerevisiae

Walter, D., Matter, A., & Fahrenkrog, B. (2010) · Journal of Cell Science · doi:10.1242/jcs.065938 · Cited by 45

Involvement of the Aspergillus nidulans protein kinase C with farnesol tolerance is related to the unfolded protein response

Colabardini, A. C., de Castro, P. A., de Gouvêa, P. F., Savoldi, M., Malavazi, I., Goldman, M. H. S., & Goldman, G. H. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07403.x · Cited by 45

Metacaspases are not caspases – always doubt

Enoksson, M., & Salvesen, G. S. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.45 · Cited by 42

Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast

Low, C. P., Shui, G., Liew, L. P., Büttner, S., Madeo, F., Dawes, I. W., Wenk, M. R., & Yang, H. (2008) · Journal of Cell Science · doi:10.1242/jcs.028977 · Cited by 40

Acetyl ‐l‐ carnitine protects yeast cells from apoptosis and aging and inhibits mitochondrial fission

Palermo, V., Falcone, C., Calvani, M., & Mazzoni, C. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00587.x · Cited by 39

Paradoxically, prior acquisition of antioxidant activity enhances oxidative stress‐induced cell death

Murik, O., & Kaplan, A. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01957.x · Cited by 39

Expression of a metacaspase gene of Nicotiana benthamiana after inoculation with Colletotrichum destructivum or Pseudomonas syringae pv. tomato, and the effect of silencing the gene on the host response

Hao, L., Goodwin, P. H., & Hsiang, T. (2007) · Plant Cell Reports · doi:10.1007/s00299-007-0387-7 · Cited by 39

Calnexin Regulates Apoptosis Induced by Inositol Starvation in Fission Yeast

Guérin, R., Beauregard, P. B., Leroux, A., & Rokeach, L. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006244 · Cited by 36

Functional characterization of human proapoptotic molecules in yeast S. cerevisiae

Guscetti, F., Nath, N., & Denko, N. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2316fje · Cited by 30

Aspasing Out Metacaspases and Caspases: Proteases of Many Trades

Bozhkov, P. V., Smertenko, A., & Zhivotovsky, B. (2010) · Science Signaling · doi:10.1126/scisignal.3152pe48 · Cited by 20

Involvement of mitochondria and metacaspase elevation in harpinPss‐induced cell death of Saccharomyces cerevisiae

Sripriya, P., Vedantam, L. V., & Podile, A. R. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22217 · Cited by 18

Structure, expression and function of Allomyces arbuscula CDP II (metacaspase) gene

Ojha, M., Cattaneo, A., Hugh, S., Pawlowski, J. W., & Cox, J. A. (2010) · Gene · doi:10.1016/j.gene.2010.02.014 · Cited by 15

Naringin‐generated ROS promotes mitochondria‐mediated apoptosis in Candida albicans

Kim, H., & Lee, D. G. (2021) · IUBMB Life · doi:10.1002/iub.2476 · Cited by 44