A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Di Stefano, M, Nascimento-Ferreira, I, Orsomando, G, Mori, V, Gilley, J, Brown, R, Janeckova, L, Vargas, M E +15 more·2015·Cell Death & Differentiation

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  5. Axon Degeneration: Too Much NMN Is Actually Bad?
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  20. Loss of highwire protects against the deleterious effects of traumatic brain injury in Drosophila Melanogaster
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  21. NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport
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  22. Some reminiscences on studies of age‐dependent and activity‐dependent degeneration of sensory and motor endings in mammalian skeletal muscle
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  23. Axon Death Pathways Converge on Axed to Promote Axon Disassembly
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  26. Peer Review #1 of "Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice (v0.1)"
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  33. Peer Review #2 of "Nicotinamide riboside exerts protective effect against aging-induced NAFLD-like hepatic dysfunction in mice (v0.1)"
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  36. Adaptation of a commercial NAD quantification kit to assay the base exchange activity of SARM1
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  37. Investigation of Nicotinamide Riboside Supplementation Impact on Glaucoma Health Trial (INSIGHT): A Phase 2, Randomized, Double-Blind, Placebo-Controlled Trial
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  38. SARM1, the executioner of axon degeneration, is an ADP-ribosyl transferase and autoMARylation negatively regulates its activation
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  41. Additional file 1 of Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma
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  42. Additional file 2 of Oral nicotinamide provides robust, dose-dependent structural and metabolic neuroprotection of retinal ganglion cells in experimental glaucoma
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  47. Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence
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  48. Combined pharmacological targeting of NAD+ metabolism preserves central and peripheral axons in an ex vivo model of Wallerian degeneration
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  49. Data set of: "The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila"
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  50. BindingDB Entry 50047447: TBA
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