Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice
Open accessAbstract
Astrocytes, being the principal cellular component of homoeostatic system of the central nervous system, are involved in numerous physiological functions, including maintenance of synaptic connectivity, plasticity and survival, and facilitating synaptogenesis. In many neurodegenerative diseases, including Alzheimer’s disease (AD), astrocytes undergo complex morphological and functional modifications, manifested by both degenerative and reactive changes. 1 , 2
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GFAP expression is modulated by physiological stimuli such as physical activity, enriched environments, and glucocorticoids, and fluctuates with circadian rhythms in the suprachiasmatic nucleus.
“Expression of GFAP is also modulated by physiological stimuli such as physical activity19, exposure to enriched environments19, and glucocorticoids20, and it fluctuates with circadian rhythms in the suprachiasmatic nucleus21.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [19]
The paper reports that voluntary running and enriched environments increased the surface area and volume of GFAP-positive astrocyte profiles in the hippocampus of mice (main text; page not provided). It does not establish that GFAP expression itself changed. The glucocorticoid and circadian-rhythm clauses are attached to other citations, not this source. (LLM, conf=0.84)
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References 7 · Cited by 99
Research works printed but not linked: 6
- Verkhratsky A ASN Neuro 2012 4 e00082 22455879 PMC3342593
- Rodriguez JJ Verkhratsky A Mol Neurobiol 2011 43 87 96 21161612
- Olabarria M Glia 2010 58 831 838 20140958
- Kulijewicz-Nawrot M J Anat 2012 221 252 262 22738374 PMC3458630
- Yeh CY ASN Neuro 2011 3 271 279 22103264 PMC3243908
- Williamson LL Chao A Bilbo SD Brain Behav Immun 2012 26 500 510 22281279 PMC3294275
- Authors
- Rodríguez, J. J., Terzieva, S., Olabarria, M., Lanza, R. G., & Verkhratsky, A.
- Affiliations
- Ikerbasque (ES)
- University of Manchester (GB)
- University of the Basque Country (ES)
- ORCID
- Verkhratsky, A
- Venue
- Cell Death & Disease
- Published
- 2013-06-20
- Volume
- 4
- Issue
- 6
- Pages
- e678-e678
- ISSN
- 2041-4889 (ISSN-L)
- PMC
- PMC3702309
- OpenAlex
- W1978453599
- Cited by
- 99
- References
- 7
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 6 · 2023: 14 · 2022: 5 · 2021: 15 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 7 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 1
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Cell Death and Disease (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- Alzheimer's Research Trust (ART/PG2004A/1)
- Instituto de Salud Carlos III (2008-2011)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- astrocytes, Alzheimer's disease, environmental enrichment, physical activity, hippocampus, transgenic mice, neurodegeneration, reactive astrogliosis
- MeSH terms
- Alzheimer Disease, Animals, Astrocytes, Disease Models, Animal, Environment, Glial Fibrillary Acidic Protein, Hippocampus, Housing, Animal, Mice, Transgenic, Motor Activity, Nerve Degeneration, Running, Dentate Gyrus, Cell Shape, Mice
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