The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Cyclophilin A: a key player for human disease
Open accessAbstract
Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical function of CyPA in several human diseases. This review discusses recently available data about CyPA in cardiovascular diseases, viral infections, neurodegeneration, cancer, rheumatoid arthritis, sepsis, asthma, periodontitis and aging. It is believed that further elucidations of the role of CyPA will provide a better understanding of the molecular mechanisms underlying these diseases and will help develop novel pharmacological therapies.
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Cites
Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A
Handschumacher, R. E., Harding, M. W., Rice, J., Drugge, R. J., & Speicher, D. W. (1984) · Science · doi:10.1126/science.6238408 · Cited by 1,673
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature · doi:10.1038/nature11087 · Cited by 1,293 · cited 2×
“A growing body of evidence suggests oxidative stress involvement in neurodegenerative diseases.84 In addition, many papers showed the contribution of CyPA in oxidative stress mediateddiseases.21,30,32 Recently Bell et al.85 reported the involvement of CyPA in Alzheimer disease.”
BackgroundNuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A
Flanagan, W. M., Corthésy, B., Bram, R. J., & Crabtree, G. R. (1991) · Nature · doi:10.1038/352803a0 · Cited by 1,056
Oxidative Stress and Cardiovascular Injury: Part I: Basic Mechanisms and In Vivo Monitoring of ROS
Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093660.86242.bb · Cited by 941
Coppinger, J. A., Cagney, G., Toomey, S., Kislinger, T., Belton, O., McRedmond, J. P., Cahill, D. J., Emili, A., Fitzgerald, D. J., & Maguire, P. B. (2004) · Blood · doi:10.1182/blood-2003-08-2804 · Cited by 814
Effects of the new anti-lymphocytic peptide cyclosporin A in animals.
Borel, J. F., Feurer, C., Magnée, C., & Stähelin, H. (1977) · PubMed Central · Cited by 707
The Regulation of Exosome Secretion: a Novel Function of the p53 Protein
Yu, X., Harris, S. L., & Levine, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4579 · Cited by 688
Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation
Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E., & Crabtree, G. R. (1989) · Science · doi:10.1126/science.2595372 · Cited by 664
Wang, P., & Heitman, J. (2005) · Genome biology · doi:10.1186/gb-2005-6-7-226 · Cited by 617
Catalysis of protein folding by prolyl isomerase
Lang, K., Schmid, F. X., & Fischer, G. (1987) · Nature · doi:10.1038/329268a0 · Cited by 490
Cited by
Cohen, Y. C., Zada, M., Wang, S.-Y., Bornstein, C., David, E., Moshe, A., Li, B., Shlomi-Loubaton, S., Gatt, M. E., Gur, C., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01232-w · Cited by 235
Brand, S., Moller, M., & Harvey, B. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150307004545 · Cited by 95
Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy
Han, J. M., & Jung, H. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169341 · Cited by 75
Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization
Ruiz-Estevez, M., Staats, J., Paatela, E., Munson, D., Katoku-Kikyo, N., Yuan, C., Asakura, Y., Hostager, R., Kobayashi, H., Asakura, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.006 · Cited by 39
“PPIases accelerate the interconversion by decreasing the energy barrier required for the interconversion, serving as a switch for many protein activities, including transcription, chromatin modification, and signal transduction, as well as pathogenesis of Alzheimer’s disease and cancer (Hanes, 2015; Nigro et al., 2013…”
BackgroundThe aged hematopoietic system promotes hippocampal‐dependent cognitive decline
Smith, L. K., Verovskaya, E., Bieri, G., Horowitz, A. M., von Ungern‐Sternberg, S. N. I., Lin, K., Seizer, P., Passegué, E., & Villeda, S. A. (2020) · Aging Cell · doi:10.1111/acel.13192 · Cited by 31
Metadata
- Authors
- Nigro, P., Pompilio, G., & Capogrossi, M. C.
- Venue
- Cell Death & Disease
- Published
- 2013-10-31
- Volume
- 4
- Issue
- 10
- Pages
- e888-e888
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2023055347
- Cited by
- 464
- References
- 108
- FWCI
- 8.74
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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