The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation
Abstract
One action of cyclosporin A thought to be central to many of its immunosuppressive effects is its ability to inhibit the early events of T lymphocyte activation such as lymphokine gene transcription in response to signals initiated at the antigen receptor. Cyclosporin A was found to specifically inhibit the appearance of DNA binding activity of NF-AT, AP-3, and to a lesser extent NF-κB, nuclear proteins that appear to be important in the transcriptional activation of the genes for interleukin-2 and its receptor, as well as several other lymphokines. In addition, cyclosporin A abolished the ability of the NF-AT binding site to activate a linked promoter in transfected mitogen-stimulated T lymphocytes and in lymphocytes from transgenic mice. These results indicate that cyclosporin A either directly inhibits the function of nuclear proteins critical to T lymphocyte activation or inhibits the action of a more proximal member of the signal transmission cascade leading from the antigen receptor to the nucleus.
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Cited by
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Liu, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., & Schreiber, S. L. (1991) · Cell · doi:10.1016/0092-8674(91)90124-h · Cited by 4,116
The mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
Self-citationA cell culture model for T lymphocyte clonal anergy
Schwartz, R. H. (1990) · Science · doi:10.1126/science.2113314 · Cited by 1,857
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,637
Self-citationChemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands
Schreiber, S. L. (1991) · Science · doi:10.1126/science.1702904 · Cited by 1,494
Metadata
- Authors
- Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E., & Crabtree, G. R.
- Venue
- Science
- Published
- 1989-12-22
- Volume
- 246
- Issue
- 4937
- Pages
- 1617-1620
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2011952922
- Cited by
- 664
- References
- 37
- FWCI
- 20.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Emmel, E. A., Verweij, C. L., Durand, D. B., Higgins, K. M., Lacy, E., & Crabtree, G. R. (1989). Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation. Science. https://doi.org/10.1126/science.2595372
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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