The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis
Open accessAbstract
Expression of apoptotic protease activating factor-1 (Apaf-1) gradually decreases during brain development, and this decrease is likely responsible for the decreased sensitivity of brain tissue to apoptosis. However, the mechanism by which Apaf-1 expression is decreased remains elusive. In the present study, we found that four microRNAs (miR-23a/b and miR-27a/b) of miR-23a-27a-24 and miR-23b-27b-24 clusters play key roles in modulating the expression of Apaf-1. First, we found that miR-23a/b and miR-27a/b suppressed the expression of Apaf-1 in vitro. Interestingly, the expression of the miR-23-27-24 clusters in the mouse cortex gradually increased in a manner that was inversely correlated with the pattern of Apaf-1 expression. Second, hypoxic injuries during fetal distress caused reduced expression of the miR-23b and miR-27b that was inversely correlated with an elevation of Apaf-1 expression during neuronal apoptosis. Third, we made neuronal-specific transgenic mice and found that overexpressing the miR-23b and miR-27b in mouse neurons inhibited the neuronal apoptosis induced by intrauterine hypoxia. In conclusion, our results demonstrate, in central neural system, that miR-23a/b and miR-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis. Our findings may also have implications for the potential target role of microRNAs in the treatment of neuronal apoptosis-related diseases.
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Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578
Cited by
MicroRNAs in apoptosis, autophagy and necroptosis
Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Oncotarget · doi:10.18632/oncotarget.3523 · Cited by 342
Apaf-1: Regulation and function in cell death
Shakeri, R., Kheirollahi, A., & Davoodi, J. (2017) · Biochimie · doi:10.1016/j.biochi.2017.02.001 · Cited by 313
Chaudhuri, A. D., Dastgheyb, R. M., Yoo, S.-W., Trout, A., Talbot Jr, C. C., Hao, H., Witwer, K. W., & Haughey, N. J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0369-4 · Cited by 184
Kelly, P. S., Breen, L., Gallagher, C., Kelly, S., Henry, M., Lao, N. T., Meleady, P., O'Gorman, D., Clynes, M., & Barron, N. (2015) · Biotechnology Journal · doi:10.1002/biot.201500101 · Cited by 49
Chen, Y.-C., Hsu, P.-Y., Su, M.-C., Chin, C.-H., Liou, C.-W., Wang, T.-Y., Lin, Y.-Y., Lee, C. P., Lin, M.-C., & Hsiao, C.-C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030999 · Cited by 32
Metadata
- Authors
- Chen, Q., Xu, J., Li, L., Li, H., Mao, S., Zhang, F., Zen, K., Zhang, C.-Y., & Zhang, Q.
- Venue
- Cell Death & Disease
- Published
- 2014-03-20
- Volume
- 5
- Issue
- 3
- Pages
- e1132-e1132
- ISSN
- 2041-4889 (ISSN-L)
- OpenAlex
- W2073567151
- Cited by
- 162
- References
- 3
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, Q., Xu, J., Li, L., Li, H., Mao, S., Zhang, F., Zen, K., Zhang, C.-Y., & Zhang, Q. (2014). MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death & Disease. https://doi.org/10.1038/cddis.2014.92
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