Apoptosis in the Pathogenesis and Treatment of Disease

Cell Death: The Significance of Apoptosis

Wyllie, A. H., Kerr, J. F. R., & Currie, A. R. (1980) · International review of cytology · doi:10.1016/s0074-7696(08)62312-8 · Cited by 7,235 · see citing works

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062 · see citing works

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003 · see citing works

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720 · see citing works

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,420 · see citing works

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

Vaux, D., Cory, S., & Adams, J. (1988) · Nature · doi:10.1038/335440a0 · Cited by 3,355 · see citing works

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321 · see citing works

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153 · see citing works

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

Boise, L., González‐García, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Núñez, G., & Thompson, C. B. (1993) · Cell · doi:10.1016/0092-8674(93)90508-n · Cited by 3,089 · see citing works

Induction of apoptosis in fibroblasts by c-myc protein

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941 · see citing works

p53 is required for radiation-induced apoptosis in mouse thymocytes

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864 · see citing works

Social controls on cell survival and cell death

RAFF, M. C. (1992) · Nature · doi:10.1038/356397a0 · Cited by 2,634 · see citing works

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Ji, Y. (1993) · Cell · doi:10.1016/0092-8674(93)90485-9 · Cited by 2,497 · see citing works

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Suda, T., Takahashi, T., Golstein, P., & Nagata, S. (1993) · Cell · doi:10.1016/0092-8674(93)90326-l · Cited by 2,488 · see citing works

Excitotoxic cell death

Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,304 · see citing works

Bcl-2 and the regulation of programmed cell death

Reed, J. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.1.1 · Cited by 2,287 · see citing works

Thymocyte apoptosis induced by p53-dependent and independent pathways

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., & Wyllie, A. H. (1993) · Nature · doi:10.1038/362849a0 · Cited by 2,271 · see citing works

Oxidative stress as a mediator of apoptosis

Buttke, T. M., & Sandstrom, P. A. (1994) · Immunology Today · doi:10.1016/0167-5699(94)90018-3 · Cited by 2,149 · see citing works

Mechanisms and Functions of Cell Death

Ellis, R. E., Yuan, J., & Horvitz, H. R. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.003311 · Cited by 2,063 · see citing works

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

Kägi, D., Ledermann, B., Bürki, K., Seiler, P. J., Odermatt, B., Olsen, K. J., Podack, E. R., Zinkernagel, R. M., & Hengartner, H. (1994) · Nature · doi:10.1038/369031a0 · Cited by 1,758 · see citing works

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

Novack, D. V., Sorenson, C. M., Shutter, J. R., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80065-m · Cited by 1,628 · see citing works

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

Kägi, D., Vignaux, F., Ledermann, B., Bürki, K., Depraetere, V., Nagata, S., Hengartner, H., & Golstein, P. (1994) · Science · doi:10.1126/science.7518614 · Cited by 1,513 · see citing works

Amyotrophic Lateral Ssclerosis and Structural Defects in Cu,Zn Superoxide Dismutase

Deng, H., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W.-Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., et al. (1993) · Science · doi:10.1126/science.8351519 · Cited by 1,479 · see citing works

p53 Status and the Efficacy of Cancer Therapy in Vivo

Lowe, S. W., Bodis, S. B., McClatchey, A. I., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., & Jacks, T. (1994) · Science · doi:10.1126/science.7973635 · Cited by 1,470 · see citing works

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

RAFF, M. C., Barres, B. A., Burne, J. F., Coles, H., Ishizaki, Y., & Jacobson, M. D. (1993) · Science · doi:10.1126/science.8235590 · Cited by 1,442 · see citing works

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

Gottlieb, R. A., Burleson, K. O., Kloner, R. A., Babior, B., & Engler, R. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117504 · Cited by 1,442 · see citing works

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

Yin, X.-M., Oltvai, Z., & Korsmeyer, S. (1994) · Nature · doi:10.1038/369321a0 · Cited by 1,383 · see citing works

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

Miura, M. (1993) · Cell · doi:10.1016/0092-8674(93)90486-a · Cited by 1,382 · see citing works

Apoptosis in cancer therapy: Crossing the threshold

Fisher, D. E. (1994) · Cell · doi:10.1016/0092-8674(94)90518-5 · Cited by 1,315 · see citing works

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252 · see citing works

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

Bakhshi, A., Jensen, J. P., Goldman, P., Wright, J. J., McBride, O. W., Epstein, A. L., & Korsmeyer, S. J. (1985) · Cell · doi:10.1016/s0092-8674(85)80070-2 · Cited by 1,177 · see citing works

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

Boudreau, N. J., Sympson, C. J., Werb, Z., & Bissell, M. J. (1995) · Science · doi:10.1126/science.7531366 · Cited by 1,174 · see citing works

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

Hengartner, M. O., & Horvitz, H. R. (1994) · Cell · doi:10.1016/0092-8674(94)90506-1 · Cited by 1,167 · see citing works

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

Henderson, S., Rowe, M., Gregory, C. D., Croom-Carter, D. S. G., Wang, F., Longnecker, R., Kieff, E. D., & Rickinson, A. B. (1991) · Cell · doi:10.1016/0092-8674(91)90007-l · Cited by 1,166 · see citing works

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., & Mountz, J. D. (1994) · Science · doi:10.1126/science.7510905 · Cited by 1,108 · see citing works

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

McDonnell, T. J., Troncoso, P., Brisbay, S. M., Logothetis, C. J., Chung, L. W. K., Hsieh, J., Tu, S., & Campbell, M. L. (1992) · PubMed · Cited by 1,049 · see citing works

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,030 · see citing works

The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining

Tsujimoto, Y., Gorham, J. D., Cossman, J., Jaffe, E. S., & Croce, C. M. (1985) · Science · doi:10.1126/science.3929382 · Cited by 990 · see citing works

Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

Ray, C. A., Black, R. A., Kronheim, S. R., Greenstreet, T. A., Sleath, P. R., Salvesen, G. S., & Pickup, D. J. (1992) · Cell · doi:10.1016/0092-8674(92)90223-y · Cited by 977 · see citing works

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

Roy, N., Mahadevan, M. S., McLean, M., Shutter, G., Yaraghi, Z., Farahani, R. M., Baird, S. D., Besner-Johnston, A., Lefebvre, C. A., Kang, X., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90461-1 · Cited by 974 · see citing works

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

Kozopas, K. M., Yang, T., Buchan, H. L., Zhou, P., & Craig, R. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.8.3516 · Cited by 964 · see citing works

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

Cleary, M. L., & Sklar, J. L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.21.7439 · Cited by 955 · see citing works

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

Strasser, A., Harris, A. W., Bath, M. L., & Cory, S. (1990) · Nature · doi:10.1038/348331a0 · Cited by 905 · see citing works

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

Nuñez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., & Korsmeyer, S. J. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3602 · Cited by 899 · see citing works

Programmed Death of T Cells in HIV-1 Infection

Meyaard, L., Otto, S. A., Jonker, R. R., Mijnster, M. J., Keet, R., & Miedema, F. F. (1992) · Science · doi:10.1126/science.1352911 · Cited by 898 · see citing works

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

Williams, G. T., Smith, C. A., Spooncer, E., Dexter, T. M., & Taylor, D. R. (1990) · Nature · doi:10.1038/343076a0 · Cited by 887 · see citing works

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

Groux, H., Torpier, G., Monté, D., Mouton, Y., Capron, A., & Ameisen, J. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.2.331 · Cited by 881 · see citing works

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

Miyashita, T., & Reed, J. (1993) · Blood · doi:10.1182/blood.v81.1.151.151 · Cited by 878 · see citing works

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S., & Harris, A. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8661 · Cited by 861 · see citing works

Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

Wang, L., Miura, M., Bergeron, L., Zhu, H., & Yuan, J. (1994) · Cell · doi:10.1016/s0092-8674(94)90422-7 · Cited by 836 · see citing works

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells

Heusel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H., & Ley, T. J. (1994) · Cell · doi:10.1016/0092-8674(94)90376-x · Cited by 815 · see citing works

Prevention of Apoptosis by a Baculovirus Gene During Infection of Insect Cells

Clem, R. J., Fechheimer, M., & Miller, L. K. (1991) · Science · doi:10.1126/science.1962198 · Cited by 813 · see citing works

Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?

Lü, X. (1993) · Cell · doi:10.1016/0092-8674(93)90496-d · Cited by 772 · see citing works

An evolutionary perspective on apoptosis

Vaux, D. L., Haecker, G., & Strasser, A. (1994) · Cell · doi:10.1016/0092-8674(94)90350-6 · Cited by 754 · see citing works

Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.

LaVail, M. M., Unoki, K., Yasumura, D., Matthes, M. T., Yancopoulos, G. D., & Steinberg, R. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.23.11249 · Cited by 718 · see citing works

PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM

Cohen, S. (1960) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.46.3.302 · Cited by 702 · see citing works

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

Singer, G. G., & Abbas, A. K. (1994) · Immunity · doi:10.1016/1074-7613(94)90067-1 · Cited by 697 · see citing works

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

Banda, N. K., Bernier, J., Kurahara, D., Kurrle, R., Haigwood, N. L., Sékaly, R., & Finkel, T. H. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.4.1099 · Cited by 668 · see citing works

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

Rao, L., Debbas, M. E., Sabbatini, P., Hockenbery, D. M., Korsmeyer, S. J., & White, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7742 · Cited by 660 · see citing works

Apoptosis: Final common pathway of photoreceptor death in rd, rds, and mutant mice

Chang, G.-Q., Hao, Y., & Wong, F. (1993) · Neuron · doi:10.1016/0896-6273(93)90072-y · Cited by 650 · see citing works

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

Vaux, D. L., Weissman, I. L., & Kim, S. K. (1992) · Science · doi:10.1126/science.1470921 · Cited by 628 · see citing works

bcl-2 inhibits death of central neural cells induced by multiple agents.

Zhong, L. T., Sarafian, T. A., Kane, D. J., Charles, A. C., Mah, S. P., Edwards, R. H., & Bredesen, D. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4533 · Cited by 619 · see citing works

Prevention of Vertebrate Neuronal Death by the crmA Gene

Gagliardini, V., Fernandez, P.-A., Lee, R. K. K., Drexler, H. C. A., Rotello, R. J., Fishman, M. C., & Yuan, J. (1994) · Science · doi:10.1126/science.8303301 · Cited by 612 · see citing works

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

Henderson, S., Huen, D. S., Rowe, M., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8479 · Cited by 603 · see citing works

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells

Fadok, V. A., Savill, J., Haslett, C., Bratton, D. L., Doherty, D. E., Campbell, P. A., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.12.4029 · Cited by 596 · see citing works

Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.Preprint

Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G., & Jenkins, N. A. (1994) · Genes & Development · doi:10.1101/gad.8.14.1613 · Cited by 595 · see citing works

Vitamin E protects nerve cells from amyloid βprotein toxicity

Behl, C., Davis, J. B., Cole, G. M., & Schubert, D. A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)90837-b · Cited by 582 · see citing works

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

Freeman, R. S., Estus, S., & Johnson, E. M. (1994) · Neuron · doi:10.1016/0896-6273(94)90276-3 · Cited by 567 · see citing works

p53 mutations increase resistance to ionizing radiation.

Lee, J. M., & Bernstein, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5742 · Cited by 564 · see citing works

Premature p34 cdc2 Activation Required for Apoptosis

Shi, L. F., Nishioka, W. K., Th'ng, J. P. H., Bradbury, E. M., Litchfield, D. W., & Greenberg, A. H. (1994) · Science · doi:10.1126/science.8108732 · Cited by 557 · see citing works

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

Emlen, W., Niebur, J., & Kadera, R. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3685 · Cited by 555 · see citing works

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

Tanaka, M., Ito, H., Adachi, S., Akimoto, H., Nishikawa, T., Kasajima, T., Marumo, F., & Hiroe, M. (1994) · Circulation Research · doi:10.1161/01.res.75.3.426 · Cited by 548 · see citing works

Programmed cell death and Bcl‐2 protection in the absence of a nucleus.

Jacobson, M. D., Burne, J. F., & RAFF, M. C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06459.x · Cited by 548 · see citing works

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire

Cyster, J. G., Hartley, S. B., & Goodnow, C. C. (1994) · Nature · doi:10.1038/371389a0 · Cited by 539 · see citing works

Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

Ameisen, J. C., & Capron, A. (1991) · Immunology Today · doi:10.1016/0167-5699(91)90092-8 · Cited by 536 · see citing works

T Cell Deletion in High Antigen Dose Therapy of Autoimmune Encephalomyelitis

Critchfield, J. M., Racke, M. K., Zúñiga‐Pflücker, J. C., et al. (1994) · Science · doi:10.1126/science.7509084 · Cited by 525 · see citing works

Fas transduces activation signals in normal human T lymphocytes.

Alderson, M. R., Armitage, R. J., Maraskovsky, E., Tough, T. W., Roux, E. R., Schooley, K., Ramsdell, F., & Lynch, D. H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2231 · Cited by 520 · see citing works

Control of Programmed Cell Death by the Baculovirus Genes p35 and iap

Clem, R. J., & Miller, L. K. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5212-5222.1994 · Cited by 512 · see citing works

THE TUMOR SUPPRESSOR GENES

Levine, A. J. (1993) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.62.070193.003203 · Cited by 506 · see citing works

Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene

Levine, B., Huang, Q. R., Isaacs, J. T., Reed, J. C., Griffin, D. E., & Hardwick, J. M. (1993) · Nature · doi:10.1038/361739a0 · Cited by 489 · see citing works

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

Boyd, J. M., Malstrom, S. E., Subramanian, T., Venkatesh, L., Schaeper, U., Elangovan, B., D’Sa-Eipper, C., & Chinnadurai, G. (1994) · Cell · doi:10.1016/0092-8674(94)90202-x · Cited by 476 · see citing works

Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.

Ellis, R. E., Jacobson, D., & Horvitz, H. R. (1991) · Genetics · doi:10.1093/genetics/129.1.79 · Cited by 462 · see citing works

Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

Sharkey, J., & Butcher, S. P. (1994) · Nature · doi:10.1038/371336a0 · Cited by 455 · see citing works

Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats

Bursch, W., Paffe, S., Putz, B., Barthel, G., & Schulte‐Hermann, R. (1990) · Carcinogenesis · doi:10.1093/carcin/11.5.847 · Cited by 444 · see citing works

Cell death by apoptosis and its protective role against disease

Bursch, W., Oberhammer, F., & Schulte‐Hermann, R. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90077-j · Cited by 433 · see citing works

bcl-xLx is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria

González‐García, M., Ballestero, R. P., Ding, L., Duan, L., Boise, L., Thompson, C. B., & Núñez, G. (1994) · Development · doi:10.1242/dev.120.10.3033 · Cited by 430 · see citing works

Lymphocyte-mediated cytotoxicity: Two pathways and multiple effector molecules

Henkart, P. A. (1994) · Immunity · doi:10.1016/1074-7613(94)90063-9 · Cited by 399 · see citing works

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

Rao, V. R., Cohen, G. B., & Oprian, D. D. (1994) · Nature · doi:10.1038/367639a0 · Cited by 386 · see citing works

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

Takashima, A., Noguchi, K., Sato, K., Hoshino, T., & Imahori, K. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.16.7789 · Cited by 381 · see citing works

Apoptosis in AIDS

Gougeon, M., & Montagnier, L. (1993) · Science · doi:10.1126/science.8098552 · Cited by 372 · see citing works

Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen

Newell, M. K., Haughn, L., Maroun, C. R., et al. (1990) · Nature · doi:10.1038/347286a0 · Cited by 369 · see citing works

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

Fairbairn, L., Cowling, G. J., Reipert, B. M., & Dexter, T. M. (1993) · Cell · doi:10.1016/0092-8674(93)90462-y · Cited by 358 · see citing works

Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

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