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The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.

Zinc-finger proteins in health and disease

Open access
Cassandri, Matteo, Smirnov, Artem, Novelli, Flavia, Pitolli, Consuelo, Agostini, Massimiliano, Malewicz, Michal, Melino, Gerry, Raschellà, Giuseppe·2017·Cell Death Discovery

Abstract

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, PAR (poly-ADP-ribose) and other proteins. Thus, ZNFs are involved in the regulation of several cellular processes. In fact, ZNFs are implicated in transcriptional regulation, ubiquitin-mediated protein degradation, signal transduction, actin targeting, DNA repair, cell migration, and numerous other processes. The aim of this review is to provide a comprehensive summary of the current state of knowledge of this class of proteins. Firstly, we describe the actual classification of ZNFs, their structure and functions. Secondly, we focus on the biological role of ZNFs in the development of organisms under normal physiological and pathological conditions.

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Metadata

Authors
Cassandri, M., Smirnov, A., Novelli, F., Pitolli, C., Agostini, M., Malewicz, M., Melino, G., & Raschellà, G.
Venue
Cell Death Discovery
Published
2017-11-13
Volume
3
Issue
1
Pages
17071-17071
ISSN
2058-7716 (ISSN-L)
OpenAlex
W2770646498
Cited by
852
References
135
FWCI
15.04
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Zinc-finger proteins in health and disease. https://app.cochat.ai/papers/10.1038/cddiscovery.2017.71
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Cassandri, M., Smirnov, A., Novelli, F., Pitolli, C., Agostini, M., Malewicz, M., Melino, G., & Raschellà, G. (2017). Zinc-finger proteins in health and disease. Cell Death Discovery. https://doi.org/10.1038/cddiscovery.2017.71

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