The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism
Abstract
The ability of normal subjects to hydroxylate mephenytoin (100 mg) or debrisoquine (10 mg) after oral dosing was investigated in 156 unrelated Caucasians living in middle Tennessee. Urinary recovery of 4-hydroxymephenytoin (4-OH-M) and the urinary S:R enantiomeric ratio of mephenytoin measured in an 8-hr urine sample were investigated as phenotypic traits for mephenytoin, and the urinary metabolic ratio of debrisoquine was used to determine the debrisoquine hydroxylase phenotype. Both urinary 4-OH-M and the S:R ratio of mephenytoin discriminated between extensive (EM) and poor (PM) metabolizers of mephenytoin. The frequencies of PMs for mephenytoin and debrisoquine hydroxylation activity were 2.6% and 7.0%. These two defects in oxidative metabolism were not observed in the same subjects, which suggests that 4-hydroxylation of mephenytoin is a new polymorphism independent of that for debrisoquine.
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Citations
Cites
POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN
Mahgoub, A., Dring, L. G., Idle, J. R., Lancaster, R., & Smith, R. L. (1977) · The Lancet · doi:10.1016/s0140-6736(77)91430-1 · Cited by 1,183
Evans, D. A., Mahgoub, A., Sloan, T. P., Idle, J. R., & Smith, R. L. (1980) · Journal of Medical Genetics · doi:10.1136/jmg.17.2.102 · Cited by 536
Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man
K�pfer, A., & Preisig, R. (1984) · European Journal of Clinical Pharmacology · doi:10.1007/bf00541938 · Cited by 362
Pharmacogenetics of Tolbutamide Metabolism in Humans
Scott, J., & Poffenbarger, P. L. (1978) · Diabetes · doi:10.2337/diab.28.1.41 · Cited by 179
Larrey, D. G., Distlerath, L. M., Dannan, G. A., Wilkinson, G. R., & Guengerich, F. P. (1984) · Biochemistry · doi:10.1021/bi00307a039 · Cited by 149
Self-citationAssessment of the drug metabolism capacity of the liver.
Park, B. K. (1982) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1982.tb04950.x · Cited by 102
Evans, D. A. P., Harmer, D. W., Downham, D. Y., et al. (1983) · Journal of Medical Genetics · doi:10.1136/jmg.20.5.321 · Cited by 93
Stereoselective metabolism of mephenytoin in man.
Kupfer, A., Roberts, R. K., Schenker, S., et al. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32651-0 · Cited by 76
Cited by
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
Desta, Z., Zhao, X., Shin, J.-G., & Flockhart, D. A. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241120-00002 · Cited by 942
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Gardiner, S. J., & Begg, E. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.6 · Cited by 406
Metadata
- Authors
- Wedlund, P. J., Aslanian, W. S., McAllister, C. B., Wilkinson, G. R., & Branch, R. A.
- Venue
- Clinical Pharmacology and Therapeutics
- Publisher
- Wiley
- Published
- 1984-12
- Volume
- 36
- Issue
- 6
- Pages
- 773-780
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2087671399
- Cited by
- 263
- References
- 8
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wedlund, P. J., Aslanian, W. S., McAllister, C. B., Wilkinson, G. R., & Branch, R. A. (1984). Mephenytoin hydroxylation deficiency in Caucasians: Frequency of a new oxidative drug metabolism polymorphism. Clinical Pharmacology and Therapeutics. https://doi.org/10.1038/clpt.1984.256
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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