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A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.
Open accessAbstract
A population survey of 258 unrelated white British subjects showed a polymorphism for the 4-oxidation of debrisoquine. "Extensive metabolisers" (EM) and "poor metabolisers" (PM) are recognisable, 8.9% of the population being PM. Nine pedigrees ascertained through PM probands show that the PM phenotype is an autosomal Mendelian recessive character. The EM phenotype is dominant and the degree of dominance has been estimated at 30%. PM subjects are more prone to hypotension during debrisoquine therapy. The alleles controlling this polymorphism appear to control the oxidation of other drugs.
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Citations
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Metadata
- Authors
- Evans, D. A., Mahgoub, A., Sloan, T. P., Idle, J. R., & Smith, R. L.
- Venue
- Journal of Medical Genetics
- Publisher
- BMJ
- Published
- 1980-04
- Volume
- 17
- Issue
- 2
- Pages
- 102-105
- ISSN
- 0022-2593 (ISSN-L)
- 1468-6244
- OpenAlex
- W2107472157
- Cited by
- 536
- References
- 0
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Evans, D. A., Mahgoub, A., Sloan, T. P., Idle, J. R., & Smith, R. L. (1980). A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population. Journal of Medical Genetics. https://doi.org/10.1136/jmg.17.2.102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
