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Cited by 399Diabetes Treatment and ManagementDiabetes Management and ResearchPharmacology and Obesity Treatment

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Dapagliflozin, a Novel, Selective SGLT2 Inhibitor, Improved Glycemic Control Over 2 Weeks in Patients With Type 2 Diabetes Mellitus

Komoroski, B, Vachharajani, N, Feng, Y, Li, L, Kornhauser, D, Pfister, M·2009·Clinical Pharmacology & Therapeutics
DOI 10.1038/clpt.2008.250
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Abstract

Dapagliflozin, administered to patients in once-daily oral doses, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that blocks the reabsorption of glucose from urine into the blood. This 14-day study randomized patients with type 2 diabetes mellitus (T2DM) to four treatment groups receiving daily oral doses of 5-, 25-, or 100-mg doses of dapagliflozin or placebo, in order to evaluate glucosuria and glycemic parameters. Significant reductions in fasting serum glucose (FSG) were observed on day 2 with 100 mg dapagliflozin (-9.3%, P < 0.001), and dose-dependent reductions were observed on day 13 with the 5-mg (-11.7%; P < 0.05), 25-mg (-13.3%; P < 0.05), and 100-mg (-21.8%; P < 0.0001) doses as compared with placebo. Significant improvements in oral glucose tolerance test (OGTT) were observed with all doses on days 2 and 13 (P < 0.001 as compared with placebo). On day 14, urine glucose values were 36.6, 70.1, and 69.9 g/day for the 5-, 25-, and 100-mg doses (as compared with no change for placebo), which were slightly lower than those on day 1. This was attributed to the decrease in filtered glucose load following improved glycemic control. Dapagliflozin produced dose-dependent increases in glucosuria and clinically meaningful changes in glycemic parameters in T2DM patients.

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Crossref · 10.1038/clpt.2008.250

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Research works printed but not linked: 3

  1. Chen J, 2008, Diabetes, 57, A682
  2. Oemar B.S, 1987, Clin. Nephrol, 27, 156
  3. Gibb D, 1995, NZ Med. J, 108, 252

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Metadata

Authors
Komoroski, B., Vachharajani, N., Feng, Y., Li, L., Kornhauser, D., & Pfister, M.
Affiliations
Bristol-Myers Squibb (United States) (US)
Corresponding author
Pfister, M
ORCID
Pfister, M
Venue
Clinical Pharmacology & Therapeutics
Publisher
Wiley
Published
2009-01-07
Volume
85
Issue
5
Pages
513-519
ISSN
  • 0009-9236 (ISSN-L)
  • 1532-6535
DOI
10.1038/clpt.2008.250
OpenAlex
W2000047428
Cited by
396
References
20
Citations by year
2026: 14 · 2025: 13 · 2024: 16 · 2023: 14 · 2022: 16 · 2021: 17 · 2020: 14 · 2019: 22 · 2018: 18 · 2017: 19 · 2016: 24 · 2015: 18 · 2014: 39 · 2013: 39 · 2012: 32
FWCI
27.68
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bristol-Myers Squibb
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Keywords
dapagliflozin, SGLT2 inhibitors, type 2 diabetes, glycemic control, glycosuria, fasting serum glucose, oral glucose tolerance test, dose-dependent effects, urinary glucose excretion
MeSH terms
Sodium-Glucose Transporter 2 Inhibitors, Administration, Oral, Benzhydryl Compounds, Blood Glucose, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Double-Blind Method, Female, Glucose Tolerance Test, Glucosides, Glycosuria, Humans, Hypoglycemic Agents, Male, Middle Aged, Time Factors, Sodium-Glucose Transporter 2

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