The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin
Abstract
Genetic variants of the organic cation transporter 2 (protein, OCT2; gene, SLC22A2) were evaluated for their contribution to the variations in the pharmacokinetics of metformin, especially to its renal elimination. Genetic variants of SLC22A2 (c.596C>T, c.602C>T, and c.808G>T) showed significant differences in metformin pharmacokinetics when compared with the reference genotype, with higher peak plasma concentration (C(max)) and area under the curve (AUC) and lower renal clearance (Cl(renal)), thereby suggesting that a decrease in transport function associated with the SLC22A2 variants results in reduced Cl(renal) of metformin and consequently leads to increased plasma concentrations.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanism by which metformin reduces glucose production in type 2 diabetes.
Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Shu, Y., Sheardown, S. A., Brown, C., Owen, R. P., Zhang, S., Castro, R. A., Ianculescu, A. G., Yue, L., Lo, J. C., Burchard, E. G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30558 · Cited by 967
Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics
Shu, Y., Brown, C., Castro, R., Shi, R., Lin, E., Owen, R., Sheardown, S., Yue, L., Burchard, E., Brett, C., et al. (2008) · Clinical Pharmacology & Therapeutics · doi:10.1038/sj.clpt.6100275 · Cited by 477
Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin
Wang, D.-S., Jonker, J. W., Kato, Y., Kusuhara, H., Schinkel, A. H., & Sugiyama, Y. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034140 · Cited by 441
Metformin is a Superior Substrate for Renal Organic Cation Transporter OCT2 rather than Hepatic OCT1
Kimura, N., Masuda, S., Tanihara, Y., Ueo, H., Okuda, M., Katsura, T., & Inui, K.-I. (2005) · Drug Metabolism and Pharmacokinetics · doi:10.2133/dmpk.20.379 · Cited by 360
Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function
Leabman, M. K., Huang, C. C., Kawamoto, M., Johns, S. J., Stryke, D., Ferrin, T. E., DeYoung, J., Taylor, T., Clark, A. G., Herskowitz, I., et al. (2002) · Pharmacogenetics · doi:10.1097/00008571-200207000-00007 · Cited by 191
Involvement of Organic Cation Transporter 1 in the Lactic Acidosis Caused by Metformin
Wang, D.-S., Kusuhara, H., Kato, Y., Jonker, J. W., Schinkel, A. H., & Sugiyama, Y. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.4.844 · Cited by 191
Metformin Transport by Renal Basolateral Organic Cation Transporter hOCT2
Kimura, N., Okuda, M., & Inui, K.-I. (2005) · Pharmaceutical Research · doi:10.1007/s11095-004-1193-3 · Cited by 176
Hormonal regulation of organic cation transporter OCT2 expression in rat kidney
Urakami, Y., Okuda, M., Saito, H., & Inui, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01525-8 · Cited by 145
Fujita, T., Urban, T., Leabman, M. K., et al. (2005) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20536 · Cited by 133
Cited by
Membrane transporters in drug development
The International Transporter Consortium, Giacomini, K. M., Huang, S.-M., Tweedie, D. J., Benet, L. Z., Brouwer, K. L. R., Chu, X., Dahlin, A., Evers, R., Fischer, V., et al. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3028 · Cited by 3,340
Clinical pharmacokinetics of metformin
Graham, G. G., Punt, J., Arora, M., Day, R. O., Doogue, M. P., Duong, J. K., Furlong, T. J., Greenfield, J. R., Greenup, L. C., Kirkpatrick, C. M., et al. (2011) · Clinical Pharmacokinetics · doi:10.2165/11534750-000000000-00000 · Cited by 1,318
Metformin pathways: pharmacokinetics and pharmacodynamics
Gong, L., Goswami, S., Giacomini, K. M., Altman, R. B., & Klein, T. E. (2012) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e3283559b22 · Cited by 495
Palomba, S., Falbo, A., Zullo, F., & Orio, F. (2009) · Endocrine Reviews · doi:10.1210/er.2008-0030 · Cited by 426
Nies, A. T., Koepsell, H., Damme, K., & Schwab, M. (2011) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-14541-4_3 · Cited by 375
Metadata
- Authors
- Song, I., Shin, H., Shim, E., Jung, I., Kim, W., Shon, J., & Shin, J.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2008-04-09
- Volume
- 84
- Issue
- 5
- Pages
- 559-562
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2023434765
- Cited by
- 268
- References
- 16
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin. https://app.cochat.ai/papers/10.1038/clpt.2008.61
- The paper
- Song, I., Shin, H., Shim, E., Jung, I., Kim, W., Shon, J., & Shin, J. (2008). Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/clpt.2008.61
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
