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A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity
Abstract
Isoniazid (INH)-induced hepatotoxicity remains a significant clinical problem, and the current mechanistic hypothesis is incomplete; it is simply referred to as metabolic idiosyncrasy,1 which is believed to involve cytotoxicity caused by bioactivation of acetylhydrazine,2 a metabolite of INH. However, this hypothesis is based on animal studies, involving characteristics that are very different from those that pertain to hepatotoxicity in humans, such as delayed onset. This issue therefore deserves a fresh look. Clinical Pharmacology & Therapeutics (2011) 89 6, 911–914. doi:10.1038/clpt.2010.355
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Cited by
Shuhendler, A. J., Pu, K., Cui, L., Uetrecht, J. P., & Rao, J. (2014) · Nature Biotechnology · doi:10.1038/nbt.2838 · Cited by 623
Self-citationIsoniazid metabolism and hepatotoxicity
Wang, P., Pradhan, K., Zhong, X.-B., & Ma, X. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.07.014 · Cited by 257
PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2
McDonagh, E. M., Boukouvala, S., Aklillu, E., Hein, D. W., Altman, R. B., & Klein, T. E. (2014) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0000000000000062 · Cited by 146
Whritenour, J., Ko, M., Zong, Q., Wang, J., Tartaro, K., Schneider, P., Olson, E., Van Volkenburg, M., Serrano, J., Hayashi, P., et al. (2017) · Journal of Immunotoxicology · doi:10.1080/1547691x.2016.1254305 · Cited by 37
Metadata
- Authors
- Metushi, I. G., Cai, P., Zhu, X., Nakagawa, T., & Uetrecht, J. P.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2011-03-16
- Volume
- 89
- Issue
- 6
- Pages
- 911-914
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W2065390851
- Cited by
- 190
- References
- 0
- FWCI
- 15.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Metushi, I. G., Cai, P., Zhu, X., Nakagawa, T., & Uetrecht, J. P. (2011). A Fresh Look at the Mechanism of Isoniazid-Induced Hepatotoxicity. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/clpt.2010.355
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