The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men
Abstract
Evidence about the association between treatment with high-risk medicines and frailty in older individuals is limited. We investigated the relationship between high-risk prescribing and frailty at baseline, as well as 2-year incident frailty, in 1,662 men ≥70 years of age. High-risk prescribing was defined as polypharmacy (≥5 medicines), hyperpolypharmacy (≥10 medicines), and by the Drug Burden Index (DBI), a dose-normalized measure of anticholinergic and sedative medicines. At baseline, frail participants had adjusted odds ratios (ORs) of 2.55 (95% confidence interval, CI: 1.69-3.84) for polypharmacy, 5.80 (95% CI: 2.90-11.61) for hyperpolypharmacy, and 2.33 (95% CI: 1.58-3.45) for DBI exposure, as compared with robust participants. Of the 1,242 men who were robust at baseline, 6.2% developed frailty over two years. Adjusted ORs of incident frailty were 2.45 (95% CI: 1.42-4.23) for polypharmacy, 2.50 (95% CI: 0.76-8.26) for hyperpolypharmacy, and 2.14 (95% CI: 1.25-3.64) for DBI exposure. High-risk prescribing may contribute to frailty in community-dwelling older men.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
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Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025
Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure
Hillege, H. L., Nitsch, D., Pfeffer, M. A., Swedberg, K., McMurray, J. J. V., Yusuf, S., Granger, C. B., Michelson, E. L., Östergren, J., Cornel, J. H., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.580506 · Cited by 945
Jyrkkä, J., Enlund, H., Lavikainen, P., Sulkava, R., & Hartikainen, S. (2011) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.2116 · Cited by 417
LaCroix, A. Z., Gray, S. L., Aragaki, A., Cochrane, B. B., Newman, A. B., Kooperberg, C. L., Black, H., Curb, J. D., Greenland, P., & Woods, N. F. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.4.369 · Cited by 84
Cited by
Health Outcomes Associated with Polypharmacy in Community‐Dwelling Older Adults: A Systematic Review
Fried, T. R., O'Leary, J., Towle, V., Goldstein, M. K., Trentalange, M., & Martin, D. K. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13153 · Cited by 721
Polypharmacy and Medication Management in Older Adults
Kim, J., & Parish, A. L. (2017) · Nursing Clinics of North America · doi:10.1016/j.cnur.2017.04.007 · Cited by 245
Hirani, V., Naganathan, V., Blyth, F., Le Couteur, D. G., Seibel, M. J., Waite, L. M., Handelsman, D. J., & Cumming, R. G. (2017) · Age and Ageing · doi:10.1093/ageing/afw214 · Cited by 246
Self-citationAssessing medication burden and polypharmacy: finding the perfect measure
Gnjidic, D., Tinetti, M., & Allore, H. G. (2017) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1301206 · Cited by 54
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Metadata
- Authors
- Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V, Cumming, R. G., Handelsman, D. J., McLachlan, A. J., Abernethy, D. R., Banks, E., & Le Couteur, D. G.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2012-02-01
- Volume
- 91
- Issue
- 3
- Pages
- 521-528
- ISSN
- 0009-9236 (ISSN-L)
- 1532-6535
- OpenAlex
- W1968911438
- Cited by
- 303
- References
- 6
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gnjidic, D., Hilmer, S. N., Blyth, F. M., Naganathan, V, Cumming, R. G., Handelsman, D. J., McLachlan, A. J., Abernethy, D. R., Banks, E., & Le Couteur, D. G. (2012). High-Risk Prescribing and Incidence of Frailty Among Older Community-Dwelling Men. Clinical Pharmacology & Therapeutics. https://doi.org/10.1038/clpt.2011.258
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