The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
Health Outcomes Associated with Polypharmacy in Community‐Dwelling Older Adults: A Systematic Review
Open accessAbstract
Objectives: To summarize evidence regarding the health outcomes associated with polypharmacy, defined as number of prescribed medications, in older community‐dwelling persons. Design: Systematic review of MEDLINE (Ovid SP 1946 to May, Week 3, 2014). Setting: Community. Participants: Observational studies examining health outcomes according to number of prescription medications taken. Measurements: Association between number of medications and health outcomes. Because of the importance of comorbidity as a potential confounder of the relationship between polypharmacy and health outcomes, articles were assessed regarding the quality of their adjustment for confounding. Results: Of the 50 studies identified, the majority that were rated good in terms of their adjustment for comorbidity demonstrated relationships between polypharmacy and a range of outcomes, including falls, fall outcomes, fall risk factors, adverse drug events, hospitalization, mortality, and measures of function and cognition. However, a number of these studies failed to demonstrate associations, as did a substantial proportion of studies rated fair or poor. Conclusion: Data are mixed regarding the relationship between polypharmacy, considered in terms of number of medications, and adverse outcomes in community‐dwelling older persons. Because of the challenge of confounding, randomized controlled trials of medication discontinuation may provide more‐definitive evidence regarding this relationship than observational studies can provide.
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Adverse Drug Events in Ambulatory Care
Gandhi, T. K., Weingart, S. N., Borus, J., Seger, A. C., Peterson, J., Burdick, E., Seger, D. L., Shu, K., Federico, F., Leape, L. L., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmsa020703 · Cited by 1,345
Multimorbidity in Older Adults
Salive, M. E. (2013) · Epidemiologic Reviews · doi:10.1093/epirev/mxs009 · Cited by 1,341
Risk Factors for Falls in a Community-Based Prospective Study of People 70 Years and Older
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Management of Depression in Older Adults: A Review
Kok, R. M., & Reynolds, C. F. (2017) · JAMA · doi:10.1001/jama.2017.5706 · Cited by 890
An update on the clinical consequences of polypharmacy in older adults: a narrative review
Wastesson, J. W., Morin, L., Tan, E. C. K., & Johnell, K. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1546841 · Cited by 617
Adverse Outcomes of Polypharmacy in Older People: Systematic Review of Reviews
Davies, L. E., Spiers, G., Kingston, A., Todd, A., Adamson, J., & Hanratty, B. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2019.10.022 · Cited by 544
Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences
Pazan, F., & Wehling, M. (2021) · European Geriatric Medicine · doi:10.1007/s41999-021-00479-3 · Cited by 542
Evidence on multimorbidity from definition to intervention: An overview of systematic reviews
Xu, X., Mishra, G. D., & Jones, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.003 · Cited by 397
Metadata
- Authors
- Fried, T. R., O'Leary, J., Towle, V., Goldstein, M. K., Trentalange, M., & Martin, D. K.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2014-12
- Volume
- 62
- Issue
- 12
- Pages
- 2261-2272
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W1972148020
- Cited by
- 721
- References
- 79
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Fried, T. R., O'Leary, J., Towle, V., Goldstein, M. K., Trentalange, M., & Martin, D. K. (2014). Health Outcomes Associated with Polypharmacy in Community‐Dwelling Older Adults: A Systematic Review. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.13153
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