The DOI matches its Crossref record.
Reducing Elevated Plasma LDL Cholesterol: The Central Role of the LDL Receptor
Abstract
Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for cardiovascular disease (CVD), and reduction of elevated LDL-C reduces mortality in patients at risk. This benefit has evolved from the use of statins and knowledge of the LDL receptor (LDLR). The most potent drugs used for dyslipidemias act by mechanisms that involve this receptor. Advances in molecular genetics and understanding of the regulation of this receptor have revealed several pharmacological targets that are being explored to develop more targeted therapies for dyslipidemias.
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The amount of LDLR on the surface of hepatocytes is the primary determinant of plasma LDL-cholesterol level.
“The amount of the low-density lipoprotein receptor (LDLR) on the surface of hepatocytes is the primary determinant of plasma low-density lipoprotein (LDL)-cholesterol level.”
From Post-translational regulation of the low-density lipoprotein receptor provides new targets for cholesterol regulation (2024) · cites this paper as [15]
LDLR abundance on hepatocyte membranes is inversely correlated with circulating LDL-C levels in both mice and humans.
“This observation aligns with prior findings that LDLR abundance on hepatocyte membranes is inversely correlated with circulating LDL-C levels in both mice and humans58.”
From ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver (2025) · cites this paper as [58]
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Cited by
Sorted by citations
Aldworth, H., & Hooper, N. M. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230918 · Cited by 11
Chen, J., Huang, H., Chen, C., Xia, G., Huang, H., Xiong, Y., Luo, P., Chen, Y., Li, J., Wen, L., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08818-x · Cited by 1
Metadata
- Authors
- Vincent, J.
- Venue
- Clinical Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2014-07
- Volume
- 96
- Issue
- 1
- Pages
- 3-7
- ISSN
- 0009-9236
- 1532-6535
- Cited by
- 10
- References
- 0
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