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Cited by 307

The DOI matches its Crossref record.

How LDL Receptors Influence Cholesterol and Atherosclerosis

Brown, Michael S., Goldstein, Joseph L.·1984·Scientific American
DOI 10.1038/scientificamerican1184-58
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Crossref · 10.1038/scientificamerican1184-58

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  • LDL clearance from the circulation by LDLR-mediated endocytosis by hepatic and peripheral tissues and subsequent feedback regulation of endogenous synthesis of cholesterol is a key determinant of serum LDL level.

    “LDL clearance from the circulation by LDL receptor (LDLR)-mediated endocytosis by hepatic and peripheral tissues and subsequent feedback regulation of endogenous synthesis of cholesterol is a key determinant of serum LDL level”

    From Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol (2016) · cites this paper as [6]

  • The balance of serum cholesterol level is determined by dietary intake, synthesis, and catabolism.

    “The balance of serum cholesterol level is determined by dietary intake, synthesis, and catabolism”

    From Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol (2016) · cites this paper as [6]

  • Excessive cholesterol in the circulation, upon uptake by the liver via LDLR-mediated endocytosis, suppresses endogenous synthesis of cholesterol in the liver.

    “Excessive cholesterol in the circulation, upon uptake by the liver via LDL receptor (LDLR)-mediated endocytosis, suppresses endogenous synthesis of cholesterol in the liver”

    From Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol (2016) · cites this paper as [6]

  • The main carriers of atherogenic circulating cholesterol in humans are LDL particles, which are produced mainly by the liver to deliver cholesterol to peripheral tissues.

    “The main carriers of atherogenic circulating cholesterol in humans are the LDL particles, which are produced mainly by the liver to deliver cholesterol to peripheral tissues”

    From Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol (2016) · cites this paper as [6]

  • Hepatic cells play major roles in removing LDL from the circulation.

    “hepatic cells also play major roles in removing LDL from the circulation”

    From Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol (2016) · cites this paper as [6]

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Metadata

Authors
Brown, M. S., & Goldstein, J. L.
Venue
Scientific American
Publisher
Springer Science and Business Media LLC
Published
1984-11
Volume
251
Issue
5
Pages
58-66
ISSN
0036-8733
DOI
10.1038/scientificamerican1184-58
Cited by
307
References
0

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