The DOI matches its Crossref record; 181 of the 181 references it cites were found in a registry or an index.
Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis
Open accessAbstract
Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA (mtDNA) mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.
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Cites
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Manganese Superoxide Dismutase: Guardian of the Powerhouse
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Metabolism of [U‐ 13 C]glucose in human brain tumors in vivo
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Functional role of mitochondrial respiratory supercomplexes
Genova, M. L., & Lenaz, G. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2013.11.002 · Cited by 306
Metadata
- Authors
- Lu, J., Sharma, L. K., & Bai, Y.
- Venue
- Cell Research
- Published
- 2009-06-16
- Volume
- 19
- Issue
- 7
- Pages
- 802-815
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2024235550
- Cited by
- 278
- References
- 181
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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