The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients
Abstract
PGC-1alpha, a potent transcriptional coactivator, is the major regulator of mitochondrial biogenesis and activity in the cardiac muscle. The dysregulation of PGC-1alpha and its target genes has been reported to be associated with congenital and acquired heart diseases. By examining myocardium samples from patients with Tetralogy of Fallot, we show here that PGC-1alpha expression levels are markedly increased in patients compared with healthy controls and positively correlated with the severity of cyanosis. Furthermore, hypoxia significantly induced the expression of PGC-1alpha and mitochondrial biogenesis in cultured cardiac myocytes. Mechanistic studies suggest that hypoxia-induced PGC-1alpha expression is regulated through the AMPK signaling pathway. Together, our data indicate that hypoxia can stimulate the expression of PGC-1alpha and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocytes to increase ATP output and minimize hypoxic damage to the heart.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Under chronic hypoxia, PGC1α is upregulated, resulting in a subsequent increase of mitochondrial biogenesis [175].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [175]
Citations
Cites
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Self-citationA Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546
Self-citationMetabolic control through the PGC-1 family of transcription coactivators
Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130
Puigserver, P., & Spiegelman, B. M. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0012 · Cited by 2,076
Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis
Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
Fukuda, R., Zhang, H., Kim, J.-W., Shimoda, L., Dang, C. V., & Semenza, G. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.047 · Cited by 1,225
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054
Arany, Z., He, H., Lin, J., Hoyer, K., Handschin, C., Toka, O., Ahmad, F., Matsui, T., Chin, S., Wu, P.-H., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.002 · Cited by 694
Mitochondrial energy metabolism in heart failure: a question of balance
Huss, J. M., & Kelly, D. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24405 · Cited by 532
Cited by
Sorted by citations
AMPK, Mitochondrial Function, and Cardiovascular Disease
Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286
AMP-activated protein kinase regulation and biological actions in the heart
Zaha, V. G., & Young, L. H. (2012) · Circulation Research · doi:10.1161/circresaha.111.255505 · Cited by 279
S-Nitrosylation: An Emerging Paradigm of Redox Signaling
Fernando, V., Zheng, X., Walia, Y., Sharma, V., Letson, J., & Furuta, S. (2019) · Antioxidants · doi:10.3390/antiox8090404 · Cited by 225
Zhang, W., Ren, H., Xu, C., Zhu, C., Wu, H., Liu, D., Wang, J., Liu, L., Li, W., Ma, Q., et al. (2016) · eLife · doi:10.7554/elife.21407 · Cited by 212
Self-citationSirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress
Luo, G.-P., Zhao, J., Zhu, Y. K., Zhu, Y., Chen, B., Ma, R., Tang, F., & Xiao, Y. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4125 · Cited by 191
Yuan, Y., Huang, S., Wang, W., Wang, Y., Zhang, P., Zhu, C., Ding, G., Liu, B., Yang, T., & Zhang, A. (2012) · Kidney International · doi:10.1038/ki.2012.188 · Cited by 159
Morris, K. C., Lin, H. W., Thompson, J. W., & Pérez‐Pinzón, M. A. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.229 · Cited by 131
Hypoxia Activation of Mitophagy and Its Role in Disease Pathogenesis
Wu, H., & Chen, Q. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6204 · Cited by 119
Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore
Belosludtsev, K. N., Belosludtseva, N. V., & Dubinin, M. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186559 · Cited by 124
Tseng, A. H.-H., Wu, L.-H., Shieh, S.-S., & Wang, D. L. (2014) · Biochemical Journal · doi:10.1042/bj20140213 · Cited by 114
Self-citationYuan, Y., Chen, Y., Zhang, P., Huang, S., Zhu, C., Ding, G., Liu, B., Yang, T., & Zhang, A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.015 · Cited by 116
Lecarpentier, Y., CLAES, V. A., Duthoit, G., & Hébert, J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00429 · Cited by 98
Targeting energy pathways in kidney disease: the roles of sirtuins, AMPK, and PGC1α
Clark, A. J., & Parikh, S. M. (2020) · Kidney International · doi:10.1016/j.kint.2020.09.037 · Cited by 96
Jiang, Z., Cowell, R. M., & Nakazawa, K. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00116 · Cited by 91
Rational construction of a reversible arylazo-based NIR probe for cycling hypoxia imaging in vivo
Zhang, Y., Zhao, W., Chen, Y., Yuan, H., Fang, H., Yao, S., Zhang, C., Xu, H., Li, N., Liu, Z., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22855-0 · Cited by 88
Self-citationSun, L., Zhao, M., Yu, X., Wang, H., He, X., Liu, J., & Zang, W. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24277 · Cited by 90
Nuamnaichati, N., Mangmool, S., Chattipakorn, N., & Parichatikanond, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00805 · Cited by 83
The implications of mitochondrial DNA copy number regulation during embryogenesis
Carling, P. J., Cree, L. M., & Chinnery, P. F. (2011) · Mitochondrion · doi:10.1016/j.mito.2011.05.004 · Cited by 79
Zhang, H., Liu, B., Li, T., Zhu, Y. K., Luo, G.-P., Jiang, Y., Tang, F., Zhao, J., & Xiao, Y. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3213 · Cited by 80
ROS homeostasis, a key determinant in liver ischemic-preconditioning
Priéto, I., & Monsalve, M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.036 · Cited by 81
Zhao, Y., Zhu, S., Wang, H., Wang, L., Du, T., Ye, Z., Zhai, D., Zhu, Z. G., Tian, X., Lu, Z., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104381 · Cited by 71
Amplification of Mitochondrial Activity in the Healing Response Following Rotator Cuff Tendon Injury
Thankam, F. G., Chandra, I., Kovilam, A. N., Diaz, C., Volberding, B. T., Dilisio, M. F., Radwan, M. M., Gross, R. M., & Agrawal, D. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-35391-7 · Cited by 63
S-Nitrosylation in Tumor Microenvironment
Sharma, V., Fernando, V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., & Furuta, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094600 · Cited by 59
Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis
Jun, J. C., Devera, R., Unnikrishnan, D. C., Shin, M., Bevans‐Fonti, S., Yao, Q., Rathore, A., Younas, H., Halberg, N., Scherer, P. E., et al. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1480-6 · Cited by 58
Hypoxia Signaling in Parkinson’s Disease: There Is Use in Asking “What HIF?”
Pinilla, L. L., Ugun‐Klusek, A., Rutella, S., & Girolamo, L. A. D. (2021) · Biology · doi:10.3390/biology10080723 · Cited by 52
Adaptive Cardiac Metabolism Under Chronic Hypoxia: Mechanism and Clinical Implications
Su, Z., Liu, Y., & Zhang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.625524 · Cited by 50
Microtubule associated protein 4 phosphorylation leads to pathological cardiac remodeling in mice
Li, L., Zhang, Q., Zhang, X., Zhang, J., Wang, X., Ren, J. T., Jia, J., Zhang, D., Jiang, X., Zhang, J., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.10.017 · Cited by 42
Self-citationThe potential of herbal drugs to treat heart failure: The roles of Sirt1/AMPK
Zhang, T., Xu, L., Guo, X., Tao, H., Liu, Y., Liu, X., Zhang, Y., & Meng, X. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.09.001 · Cited by 45
PATTNAIK, B. R., Bodas, M., Bhatraju, N. K., Ahmad, T., Pant, R., Guleria, R., Ghosh, B., & Agrawal, A. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.036 · Cited by 42
IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1α
Hickey, F. B., Corcoran, J. B., Docherty, N. G., Griffin, B., Bhreathnach, Ú., Furlong, F. M., Martin, F., Godson, C., & Murphy, M. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010111154 · Cited by 41
Belosludtseva, N. V., Matveeva, L. A., & Belosludtsev, K. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316833 · Cited by 40
Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy
Yang, X., Zhang, R., Nakahira, K., & Gu, Z. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124643 · Cited by 37
Self-citationIntegrated Control of Fatty Acid Metabolism in Heart Failure
Li, X., & Bi, X. (2023) · Metabolites · doi:10.3390/metabo13050615 · Cited by 34
Selvakumar, G. P., Iyer, S. S., Kempuraj, D., Raju, M., Thangavel, R., Saeed, D., Ahmed, M. E., Zahoor, H., Raikwar, S. P., Zaheer, S. A., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0882-6 · Cited by 34
Immunometabolic cross-talk in the inflamed heart
Marelli‐Berg, F. M., & Aksentijević, D. (2019) · Cell Stress · doi:10.15698/cst2019.08.194 · Cited by 36
Chiang, M., Cheng, Y., Lin, K., & Yen, C.-H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.003 · Cited by 34
Wang, D., Zhang, J., Lu, Y., Luo, Q., & Zhu, L. X. (2016) · IUBMB Life · doi:10.1002/iub.1537 · Cited by 32
Self-citationZhang, X., Li, L., Zhang, Q., Wei, Q., Lin, J., Jia, J., Zhang, J., Yan, T., Lv, Y., Jiang, X., et al. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00191 · Cited by 28
Self-citationBruns, I., Sauer, B., Burger, M. C., Eriksson, J. A., Hofmann, U., Braun, Y., Harter, P. N., Luger, A., Ronellenfitsch, M. W., Steinbach, J. P., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006993 · Cited by 31
Xu, J., Wakai, M., Xiong, K., Yang, Y., Prabakaran, A., Wu, S. P., Ahrens, D., Molina‐Portela, M. D. P., Ni, M., Bai, Y., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115403 · Cited by 35
Ohuchi, H., Kawata, M., Uemura, H., Akagi, T., Yao, A., Senzaki, H., Kasahara, S., Ichikawa, H., Motoki, H., Syoda, M., et al. (2022) · Circulation Journal · doi:10.1253/circj.cj-22-0134 · Cited by 29
Ramjiawan, A., Bagchi, R. A., Blant, A., Albak, L., Cavasin, M. A., Horn, T. R., McKinsey, T. A., & Czubryt, M. P. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00262.2012 · Cited by 27
Veeranki, S., Givvimani, S., Pushpakumar, S. B., & Tyagi, S. C. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00003.2014 · Cited by 23
Repeated sprint exercise in hypoxia stimulates HIF-1-dependent gene expression in skeletal muscle
Nava, R. C., McKenna, Z. J., Fennel, Z. J., Berkemeier, Q., Ducharme, J. B., Magalhães, F. D. C., Amorim, F. T., & Mermier, C. M. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04909-3 · Cited by 27
Rao, J., Li, J., Liu, Y., Lü, P., Sun, X., Sugumaran, P. K., & Zhu, D. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1313-z · Cited by 22
Ravindran, S., & Kurian, G. A. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09794-8 · Cited by 23
Nam, H. G. W., Kim, W., Yoo, D. Y., Choi, J. H., Won, M., Hwang, I. K., Jeong, J. H., Hwang, H. S., & Moon, S. M. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000158 · Cited by 22
Chi, L., Wang, N., Yang, W., Wang, Q., Zhao, D., Sun, T., & Li, W. (2019) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-019-09886-1 · Cited by 22
Self-citationMitochondria in hypoxic pulmonary hypertension, roles and the potential targets
Geng, Y., Hu, Y., Zhang, F., Tuo, Y., Ge, R., & Bai, Z. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1239643 · Cited by 26
Druyan, S., & Levi, E. (2012) · Gene Expression Patterns · doi:10.1016/j.gep.2012.05.001 · Cited by 19
Sanz, M., Farine, E., Niederberger, P., Méndez‐Carmona, N., Wyss, R. K., Arnold, M., Gulac, P., Fiedler, M., Gressette, M., Garnier, A., et al. (2018) · American Journal of Transplantation · doi:10.1111/ajt.15024 · Cited by 19
Li, F., Guo, S., Wang, C., Huang, X., Wang, H., Tan, X., Cai, Q., Wu, J., Zhang, Y., Chen, X., et al. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2319-1 · Cited by 19
Song, H., Polster, B. M., & Thompson, L. P. (2021) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00004.2021 · Cited by 18
Preobrazenski, N., Islam, H., & Gurd, B. J. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-021-04669-6 · Cited by 18
Disorders of gut microbiota in children with Tetralogy of Fallot
Liu, X., Lu, S., Shao, Y., Zhang, D., Tu, J., & Chen, J. (2022) · Translational Pediatrics · doi:10.21037/tp-22-33 · Cited by 17
Rodríguez‐Calvo, R., Vázquez‐Carrera, M., Masana, L., & Neumann, D. (2015) · PPAR Research · doi:10.1155/2015/785783 · Cited by 17
From metabolism to malignancy: the multifaceted role of PGC1α in cancer
Wang, Y., Peng, J., Yang, D., Xing, Z., Jiang, B., Xu, D., Jiang, C., Ouyang, B., & Su, L. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1383809 · Cited by 19
Histologic alterations in tetralogy of Fallot
Alpat, Ş., Yilmaz, M., Onder, S. C., Sargon, M. F., Güvener, M., Doğan, R., Demircin, M., & Paşaoğlu, İ. (2016) · Journal of Cardiac Surgery · doi:10.1111/jocs.12873 · Cited by 15
Tai, S., Fu, Y. H., Yang, Y., & Wang, J. J. (2015) · Transplantation Proceedings · doi:10.1016/j.transproceed.2014.11.057 · Cited by 12
Self-citationNatarajan, B., Arige, V., Khan, A. A., Reddy, S. S., Barthwal, M. K., Mahapatra, N. R., Barthwal, M. K., & Mahapatra, N. R. (2020) · Hypertension Research · doi:10.1038/s41440-020-00539-4 · Cited by 11
Han, Y., Xie, N., Cao, L., Zhao, X., Liu, X., Jiang, H., & Chi, Z. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.06.020 · Cited by 11
Grape Powder Improves Age‐Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats
Pokkunuri, I. D., Ali, Q., & Asghar, M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6135319 · Cited by 11
Skeletal Muscle mRNA Response to Hypobaric and Normobaric Hypoxia After Normoxic Endurance Exercise
Ross, C. I., Shute, R. J., Ruby, B. C., & Slivka, D. R. (2019) · High Altitude Medicine & Biology · doi:10.1089/ham.2018.0147 · Cited by 11
Wang, M., Chen, J., Zhang, Z., Wang, T., Zhao, J., Wang, X., Wang, J., & Zhuang, H. (2025) · Nutrients · doi:10.3390/nu17172800 · Cited by 10
Self-citationRole of MOTS-c in the regulation of bone metabolism
Yi, X., Hu, G., Yang, Y., Li, J., Jin, J., & Chang, B. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1149120 · Cited by 10
Ren, C., Xi, L., Li, H., Pan, Z., Li, Y., Wang, G., Dai, J., He, D., Fan, S., & Wang, Q. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123084 · Cited by 12
Self-citationPivotal role of activating transcription factor 6α in myocardial adaptation to chronic hypoxia
Zhao, J., Li, J.-B., Ma, R., Chen, L., Wang, X., & Xiao, Y. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.03.004 · Cited by 10
Ngamsiri, P., Watcharasit, P., & Satayavivad, J. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.11.003 · Cited by 10
Qin, J., Wang, Y., Tan, L., Yang, Y., Fu, Y., Wu, C., Duan, H., Li, C., Li, H., Zhou, S., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158385 · Cited by 9
Liang, W., Wu, H., Long, Q., Lin, H. L., Lv, X., Ma, W., Wu, T., Ai, L., Zheng, Q., Guo, J., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123564 · Cited by 9
Li, J., Zhang, Y., Liu, Y., Shen, T., Zhang, H., Xing, Y. T., & Zhu, D. (2014) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2014.10.015 · Cited by 9
Ji, S., Xu, X., Li, Y., Sun, S., Fu, Q., Qiu, Y., Wang, S., Xia, S., Wang, F., Zhang, F., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17121727 · Cited by 8
Bahr, A. C., Naasani, L. I. S., de Gregório, E., Wink, M. R., Araújo, A. S. D. R., Türck, P., & Lago, P. D. (2024) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2024.112991 · Cited by 9
Xu, W., Hou, D., Jiang, X., Lu, Z., Guo, T., Liu, Y., Wang, D., Zen, K., Yu, B., & Zhang, C. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.24015 · Cited by 8
Self-citationGuo, L., & Gu, Z. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1207603 · Cited by 7
Self-citationElbatarny, M., Lu, Y. T., Hu, M., Coles, J. C., Mital, S. R., Ross‐White, A., Honjo, O., Barron, D. J., & Gramolini, A. O. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105839 · Cited by 7
Xie, W., Hong, Z., Xie, Y., Hou, K., Li, S., Fang, M., Guan, Y., Zhang, Z., & Zhang, M. (2025) · The FASEB Journal · doi:10.1096/fj.202501549rr · Cited by 5
Ferulic acid protects against stress-induced myocardial injury in mice
Li, S., He, P., Liu, J., Zang, S., Luo, J., Luo, Y., Zhu, S., & Zang, L. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117309 · Cited by 5
Molecular alterations during female reproductive aging: Can aged oocytes remind youth?
Takahashi, Y. K. (2012) · InTech eBooks · doi:10.5772/35938 · Cited by 5
Dioxygen and Metabolism; Dangerous Liaisons in Cardiac Function and Disease
Angelini, A., Pi, X., & Xie, L. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01044 · Cited by 6
Exploring mitochondrial dynamics and localization under cellular stress: A comprehensive insight
Agarwal, S., Karuppusamy, K. A., & Gupta, A. K. (2025) · Journal of Biosciences · doi:10.1007/s12038-025-00514-6 · Cited by 4
Kar, A., Gupta, S., Matilal, A., & Sarkar, S. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2491989 · Cited by 4
Impact of Hypoxic Exercise Recovery on Skeletal Muscle Glycogen and Gene Expression
Slivka, D. R., Dumke, C. L., Hailes, W. S., & Ruby, B. C. (2021) · High Altitude Medicine & Biology · doi:10.1089/ham.2021.0028 · Cited by 4
Harley, G., & Mount, P. F. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103741 · Cited by 3
Warwick, A. M., Bomze, H. M., Wang, L., Hao, Y., Stinnett, S. S., & Gospe, S. M. (2024) · Scientific Reports · doi:10.1038/s41598-024-75916-x · Cited by 3
Cancer cachexia has many symptoms but only one cause: anoxia
Koltai, T. (2020) · F1000Research · doi:10.12688/f1000research.22624.1 · Cited by 3
Meta‐analysis reveals differential gene expression in tetralogy of Fallot versus controls
Voskamp, S., Hammonds, M., Knapp, T. M., Pekmezian, A. L., Hadley, D., & Nelson, J. S. (2023) · Birth Defects Research · doi:10.1002/bdr2.2293 · Cited by 3
Liu, S., Ding, R., Huang, L., Lv, J., Sun, Z., Wang, X., & Duan, J. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.05.041 · Cited by 2
PGC-1α-Derived Peptide Influences Energy in Normal Human Dermal Fibroblasts
Suchá, L., Šuláková, R., Fryčák, R., & Dolečková, I. (2018) · Cosmetics · doi:10.3390/cosmetics5010018 · Cited by 2
Zhang, Z., Zhao, Z., Luo, Z., Duan, X., Xiao, Y., Huang, J., Wang, Q., Liu, F., Ding, L., Gu, L., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.03.009 · Cited by 1
Self-citationThe Role of Mitochondrial DNA in Tumorigenesis
Yeung, K. Y., Dickinson, A., & John, J. C. S. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-101-1_6
PGC-1 Alpha Levels in Muscle Fibers During Hind Limb Ischemia. 6 7
Veeranki, S., Givvimani, S., Pushpakumar, S. B., & Tyagi, S. C. (2014)
Iden, J. (2015) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3vd6pg31
Natarajan, B., Arige, V., Khan, A. A., Reddy, S. S., Santhoshkumar, R., Sagar, B. K. C., Barthwal, M. K., & Mahapatra, N. R. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/816470
Wood, A. J. (2021) · Scholarship@Western (Western University)
Increase in blood derived mitochondrial DNA copy number in strabismus patients
Zehra, Z., Zia, M. A., Siddiqui, S. N., von Bartheld, C. S., Azam, M., & Qamar, R. (2024) · Journal of American Association for Pediatric Ophthalmology and Strabismus · doi:10.1016/j.jaapos.2024.104042
Mitochondria in Pediatric Cardiovascular Diseases
Marı́n-Garcı́a, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_12
PGC1α-mediated upregulation of PHD2 represses HIF-signaling, limiting prostate cancer progression
Fagoaga-Eugui, M., Martín-Martín, N., Zabala‐Letona, A., Iriondo, O., Talamillo, A., Valcárcel-Jiménez, L., Pérez-Andrés, E., Carlivaris, O., Garcia‐Longarte, S., Medina‐Jover, F., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01858-8
Metadata
- Authors
- Zhu, L., Wang, Q., Zhang, L., Fang, Z., Zhao, F., Lv, Z., Gu, Z., Zhang, J., Wang, J., Zen, K., Xiang, Y., Wang, D., & Zhang, C.-Y.
- Affiliations
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Nanjing Drum Tower Hospital (CN)
- University of Toronto (CA)
- Corresponding author
- Wang, Jin
- Xiang, Yang
- Wang, Dongjin
- ORCID
- Venue
- Cell Research
- Published
- 2010-04-06
- Volume
- 20
- Issue
- 6
- Pages
- 676-687
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2153310447
- Cited by
- 101
- References
- 51
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 12
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- PGC-1α, mitochondrial biogenesis, hypoxia, tetralogy of Fallot, congenital heart disease, cardiomyocytes, AMPK signaling, cyanosis, myocardium, myocardial energy metabolism
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adolescent, Adult, Hypoxia, Cells, Cultured, Child, Child, Preschool, Female, Gene Expression Regulation, Heat-Shock Proteins, Humans, Infant, Male, Mitochondria, Myocardium, Tetralogy of Fallot, Transcription Factors, Signal Transduction, Biomarkers, Up-Regulation, Myocytes, Cardiac, AMP-Activated Protein Kinases, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review