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Hypoxia induces PGC-1α expression and mitochondrial biogenesis in the myocardium of TOF patients
Abstract
PGC-1alpha, a potent transcriptional coactivator, is the major regulator of mitochondrial biogenesis and activity in the cardiac muscle. The dysregulation of PGC-1alpha and its target genes has been reported to be associated with congenital and acquired heart diseases. By examining myocardium samples from patients with Tetralogy of Fallot, we show here that PGC-1alpha expression levels are markedly increased in patients compared with healthy controls and positively correlated with the severity of cyanosis. Furthermore, hypoxia significantly induced the expression of PGC-1alpha and mitochondrial biogenesis in cultured cardiac myocytes. Mechanistic studies suggest that hypoxia-induced PGC-1alpha expression is regulated through the AMPK signaling pathway. Together, our data indicate that hypoxia can stimulate the expression of PGC-1alpha and mitochondrial biogenesis in the cardiac myocytes, and this process might provide a potential adaptive mechanism for cardiac myocytes to increase ATP output and minimize hypoxic damage to the heart.
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“Under chronic hypoxia, PGC1α is upregulated, resulting in a subsequent increase of mitochondrial biogenesis [175].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [175]
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Metadata
- Authors
- Zhu, L., Wang, Q., Zhang, L., Fang, Z., Zhao, F., Lv, Z., Gu, Z., Zhang, J., Wang, J., Zen, K., Xiang, Y., Wang, D., & Zhang, C.-Y.
- Affiliations
- State Key Laboratory of Pharmaceutical Biotechnology (CN)
- Nanjing Drum Tower Hospital (CN)
- University of Toronto (CA)
- Corresponding author
- Wang, Jin
- Xiang, Yang
- Wang, Dongjin
- ORCID
- Venue
- Cell Research
- Published
- 2010-04-06
- Volume
- 20
- Issue
- 6
- Pages
- 676-687
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2153310447
- Cited by
- 101
- References
- 51
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 6 · 2013: 5 · 2012: 12
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- PGC-1α, mitochondrial biogenesis, hypoxia, tetralogy of Fallot, congenital heart disease, cardiomyocytes, AMPK signaling, cyanosis, myocardium, myocardial energy metabolism
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Adolescent, Adult, Hypoxia, Cells, Cultured, Child, Child, Preschool, Female, Gene Expression Regulation, Heat-Shock Proteins, Humans, Infant, Male, Mitochondria, Myocardium, Tetralogy of Fallot, Transcription Factors, Signal Transduction, Biomarkers, Up-Regulation, Myocytes, Cardiac, AMP-Activated Protein Kinases, Young Adult
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