The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth
Open accessAbstract
An increased population of CD4(+)CD25(high)Foxp3(+) regulatory T cells (Tregs) in the tumor-associated microenvironment plays an important role in cancer immune evasion. However, the underlying mechanism remains unclear. Here we observed an increased secretion of miR-214 in various types of human cancers and mouse tumor models. Tumor-secreted miR-214 was sufficiently delivered into recipient T cells by microvesicles (MVs). In targeted mouse peripheral CD4(+) T cells, tumor-derived miR-214 efficiently downregulated phosphatase and tensin homolog (PTEN) and promoted Treg expansion. The miR-214-induced Tregs secreted higher levels of IL-10 and promoted tumor growth in nude mice. Furthermore, in vivo studies indicated that Treg expansion mediated by cancer cell-secreted miR-214 resulted in enhanced immune suppression and tumor implantation/growth in mice. The MV delivery of anti-miR-214 antisense oligonucleotides (ASOs) into mice implanted with tumors blocked Treg expansion and tumor growth. Our study reveals a novel mechanism through which cancer cell actively manipulates immune response via promoting Treg expansion.
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Cites
Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis
Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.007 · Cited by 1,476
Fu, J., Xu, D., Liu, Z., Shi, M., Zhao, P., Fu, B., Zhang, Z., Yang, H., Zhang, H., Zhou, C., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.102 · Cited by 897
Tuveson, D. A., Shaw, A. T., Willis, N. A., Silver, D. P., Jackson, E. L., Chang, S., Mercer, K. L., Grochow, R., Hock, H., Crowley, D., et al. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00085-6 · Cited by 798
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Effect of exosomal miRNA on cancer biology and clinical applications
Sun, Z., Shi, K., Yang, S., Liu, J., Zhou, Q., Wang, G., Song, J., Li, Z., Zhang, Z., & Yuan, W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0897-7 · Cited by 800
Song, Y., Dou, H., Li, X., Zhao, X., Li, Y., Liu, D., Ji, J., Liu, F., Ding, L., Ni, Y., et al. (2017) · Stem Cells · doi:10.1002/stem.2564 · Cited by 482
Chen, X., Luo, Y., Zhu, Q., Zhang, J., Huang, H., Kan, Y., Li, D., Xu, M., Liu, S., Li, J., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00612-4 · Cited by 174
Self-citationSullivan, R., Maresh, G., Zhang, X., Salomon, C., Hooper, J., Margolin, D., & Li, L. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00194 · Cited by 112
Self-citationTherapeutic reversal of Huntington’s disease by in vivo self-assembled siRNAs
Zhang, L., Wu, T., Shan, Y., Li, G., Ni, X., Chen, X., Hu, X., Lin, L., Li, Y., Guan, Y., et al. (2021) · Brain · doi:10.1093/brain/awab354 · Cited by 97
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Metadata
- Authors
- Yin, Y., Cai, X., Chen, X., Liang, H., Zhang, Y., Li, J., Wang, Z., Chen, X., Zhang, W., Yokoyama, S., Wang, C., Li, L., Li, L., Hou, D., Dong, L., Xu, T., Hiroi, T., Yang, F., Ji, H., Zhang, J., Zen, K., & Zhang, C.-Y.
- Venue
- Cell Research
- Published
- 2014-09-16
- Volume
- 24
- Issue
- 10
- Pages
- 1164-1180
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- OpenAlex
- W2160153675
- Cited by
- 282
- References
- 3
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yin, Y., Cai, X., Chen, X., Liang, H., Zhang, Y., Li, J., Wang, Z., Chen, X., Zhang, W., Yokoyama, S., Wang, C., Li, L., Li, L., Hou, D., Dong, L., Xu, T., Hiroi, T., Yang, F., Ji, H., . . . Zhang, C.-Y. (2014). Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth. Cell Research. https://doi.org/10.1038/cr.2014.121
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