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Cited by 800Extracellular vesicles in diseaseMicroRNA in disease regulationNanoparticle-Based Drug Delivery

Effect of exosomal miRNA on cancer biology and clinical applications

Open access
Sun, Zhenqiang, Shi, Ke, Yang, Shuaixi, Liu, Jinbo, Zhou, Quanbo, Wang, Guixian, Song, Junmin, Li, Zhen +2 more·2018·Molecular Cancer
DOI 10.1186/s12943-018-0897-7PMC PMC6182840
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Abstract

Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely present in various body fluids. Recently, microRNAs (miRNAs) have been identified in exosomes, the biogenesis, release, and uptake of which may involve the endosomal sorting complex required for transport (ESCRT complex) and relevant proteins. After release, exosomes are taken up by neighboring or distant cells, and the miRNAs contained within modulate such processes as interfering with tumor immunity and the microenvironment, possibly facilitating tumor growth, invasion, metastasis, angiogenesis and drug resistance. Therefore, exosomal miRNAs have a significant function in regulating cancer progression. Here, we briefly review recent findings regarding tumor-derived exosomes, including RNA sorting and delivering mechanism. We then describe the intercommunication occurring between different cells via exosomal miRNAs in tumor microenvironmnt, with impacts on tumor proliferation, vascularization, metastasis and other biological characteristics. Finally, we highlight the potential role of these molecules as biomarkers in cancer diagnosis and prognosis and tumor resistance to therapeutics.

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Cited by

Sorted by citations

Authors
Sun, Z., Shi, K., Yang, S., Liu, J., Zhou, Q., Wang, G., Song, J., Li, Z., Zhang, Z., & Yuan, W.
Affiliations
First Affiliated Hospital of Zhengzhou University (CN)
Corresponding author
  • Sun, Zhenqiang
  • Yuan, Weitang
ORCID
Venue
Molecular Cancer
Publisher
Springer Science and Business Media LLC
Published
2018-10-11
Volume
17
Issue
1
Pages
147-147
ISSN
1476-4598 (ISSN-L)
DOI
10.1186/s12943-018-0897-7
PMC
PMC6182840
OpenAlex
W2895877601
Cited by
800
References
7
Citations by year
2026: 26 · 2025: 84 · 2024: 139 · 2023: 113 · 2022: 147 · 2021: 159 · 2020: 98 · 2019: 32 · 2018: 1
FWCI
7.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Cancer (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81560385)
  • Medical Scientific and Technological Research Project of Henan Province (201702027)
  • Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University (YNQN2017035)
  • China Postdoctoral Science Foundation (2017M610462)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
exosomes, microRNA, extracellular vesicles, ESCRT complex, tumor microenvironment, antitumor immunity, metastasis, angiogenesis, drug resistance, tumor markers, cancer diagnosis and prognosis, intercellular communication, tumor progression
MeSH terms
Cancer-Associated Fibroblasts, Extracellular Matrix, Humans, Neoplasms, Prognosis, Signal Transduction, Biomarkers, RNA Transport, MicroRNAs, Exosomes

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