Vertical transmission of Zika virus targeting the radial glial cells affects cortex development of offspring mice
Open accessAbstract
The recent Zika virus (ZIKV) epidemic in Latin America coincided with a marked increase in microcephaly in newborns. However, the causal link between maternal ZIKV infection and malformation of the fetal brain has not been firmly established. Here we show a vertical transmission of ZIKV in mice and a marked effect on fetal brain development. We found that intraperitoneal (i.p.) injection of a contemporary ZIKV strain in pregnant mice led to the infection of radial glia cells (RGs) of dorsal ventricular zone of the fetuses, the primary neural progenitors responsible for cortex development, and caused a marked reduction of these cortex founder cells in the fetuses. Interestingly, the infected fetal mice exhibited a reduced cavity of lateral ventricles and a discernable decrease in surface areas of the cortex. This study thus supports the conclusion that vertically transmitted ZIKV affects fetal brain development and provides a valuable animal model for the evaluation of potential therapeutic or preventative strategies.
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The Zika virus is able to infect neuroepithelial stem cells and cortical radial glial cells and to a lesser extent postmigratory neurons, causing structural disorganization in these cells eventually leading to cell death.
“The Zika virus is able to infect neuroepithelial stem cells and cortical radial glial cells and to a lesser extent postmigratory neurons causing structural disorganization in these cells eventually leading to cell death [341–343].”
From Development of prefrontal cortex (2022) · cites this paper as [343]
The Results (pages unavailable) show Zika virus in cortical radial glial cells and a reduced neural-progenitor pool in fetal mice. The Discussion reports lower infection efficiency in differentiated young neurons, while the Results cite cell death in cultured human neural progenitors. The paper does not establish infection of neuroepithelial stem cells specifically, or show that structural disorganization of the infected cells leads to their death. (LLM, conf=0.84)
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References 40 · Cited by 283
- Authors
- Wu, K.-Y., Zuo, G.-L., Li, X.-F., Ye, Q., Deng, Y.-Q., Huang, X.-Y., Cao, W.-C., Qin, C.-F., & Luo, Z.-G.
- Affiliations
- Chinese Academy of Sciences (CN)
- Beijing Institute of Microbiology and Epidemiology (CN)
- Corresponding author
- Qin, Cheng-Feng
- Luo, Zhen-Ge
- Venue
- Cell Research
- Published
- 2016-05-13
- Volume
- 26
- Issue
- 6
- Pages
- 645-654
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC4897185
- OpenAlex
- W2372368841
- Cited by
- 283
- References
- 40
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 15 · 2021: 27 · 2020: 17 · 2019: 36 · 2018: 45 · 2017: 73 · 2016: 38 · 2015: 1
- FWCI
- 63.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell Research (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31321091, 81522025, 31330032, 31371063, 31490591, 61327902)
- Chinese Academy of Sciences (XDB02040003)
- Youth Innovation Promotion Association of the Chinese Academy of Sciences
- Youth Innovation Promotion Association
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Keywords
- Zika virus, vertical transmission, maternal infection, radial glia, fetal brain development, cortical development, microcephaly, neural progenitor cells, mouse model, congenital brain malformation
- MeSH terms
- Zika Virus Infection, Zika Virus, Animals, Cell Cycle, Cerebral Cortex, Fetus, Gene Expression Regulation, Mice, Inbred C57BL, Microcephaly, Cell Proliferation, Neural Stem Cells, Ependymoglial Cells
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