The search for better animal models of Alzheimer’s disease

King, Anthony

doi:10.1038/d41586-018-05722-9

Cited by 147Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The search for better animal models of Alzheimer’s disease

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King, Anthony·2018·Nature

DOI 10.1038/d41586-018-05722-9

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It typically requires additional expression of human tau harboring mutations associated with primary tauopathy or seeding mutant human APP knock-in mouse brain with human AD brain-derived tau to develop tau pathology in mouse models.
“It typically requires additional expression of human tau harboring mutations associated with primary tauopathy (94–96) or seeding mutant human APP knock-in mouse brain with human AD brain-derived tau (97) to develop the tau pathology.”
From Modeling late-onset Alzheimer’s disease neuropathology via direct neuronal reprogramming (2024) · cites this paper as [95]
In the section on mouse models (page not provided), the paper says that PD-APP mice do not develop tau tangles and that some models use tau mutations associated with frontotemporal dementia, sometimes alongside mutations that produce amyloid plaques. It does not describe seeding mutant APP knock-in mouse brains with human Alzheimer’s disease brain-derived tau. (LLM, conf=0.86)
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Authors: King, A.
Corresponding author: King, Anthony
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2018-07-25
Volume: 559
Issue: 7715
Pages: S13-S15
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/d41586-018-05722-9
OpenAlex: W2883910861
Cited by: 142
References: 0
Citations by year: 2026: 5 · 2025: 7 · 2024: 40 · 2023: 9 · 2022: 14 · 2021: 27 · 2020: 24 · 2019: 16
FWCI: 11.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, animal models, cell model, drug development, transgenic mouse model
MeSH terms: Aged, 80 and over, Alzheimer Disease, Animals, Callithrix, Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Macaca mulatta, Mice, Transgenic, Middle Aged, Models, Biological, Organoids, Peptide Fragments, Vaccines, Reproducibility of Results, Amyloid beta-Peptides, tau Proteins, Apolipoprotein E4, Presenilin-1, Induced Pluripotent Stem Cells, Translational Research, Biomedical, Neural Stem Cells, Protein Aggregation, Pathological

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