Blood flow forces liver growth
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Cytokines and growth factors involved in liver regeneration stimulate hepatocyte proliferation and angiogenesis, leading to the restoration of liver mass and function.
“The cytokines and growth factors involved in liver regeneration stimulate hepatocyte proliferation and angiogenesis, leading to the restoration of liver mass and function[37].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [37]
The opening section and Figure 1 say that liver endothelial-cell growth factors, including HGF, promote hepatocyte proliferation and liver growth. The paper does not establish that these factors stimulate angiogenesis or restore liver function; its discussion of therapeutic regeneration is prospective. (LLM, conf=0.87)
Experimental — accuracy not yet measuredLiver size regulation is primarily controlled by changes in portal pressure and blood flow dynamics.
“These data provides the additional confirmation that liver size regulation is primarily controlled by changes in portal pressure and blood flow dynamics[37].”
From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [37]
The Rabbany and Rafii introduction and the “Lorenz et al.” section (page numbers unavailable in our copy) link blood flow and pressure-related forces to liver-cell proliferation and growth, chiefly through mouse experiments. They do not establish that changes in portal pressure primarily control liver size; the reported association with larger human livers concerns systemic blood pressure. (LLM, conf=0.87)
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Cites
Angiocrine functions of organ-specific endothelial cells
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Self-citationInductive angiocrine signals from sinusoidal endothelium are required for liver regeneration
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Flagged first, then by citations
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Research works printed but not linked: 1
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Cited by
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“LSECs, lying at the intersection between systemic circulation and liver parenchyma, are the first cells to be exposed to shear forces generated by fluid viscosity, which can provoke mechanical signals [63].”
BackgroundNew aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease
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“Compared with those physiological cases, the number of vessels is decreased in the remaining liver and the vessels dilate to allow the same amount of blood to pass through the reduced liver tissues, leading to an increase in portal vein flow rate per liver mass, from 120 to 300 mL/ min·g liver tissue (Cantre et al., 2…”
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“This is of particular importance, as shown in a recent discovery relating the mechanical force of blood flow through the liver to growth factor signaling (Lorenz et al., 2018; Rabbany and Rafii, 2018).”
Background
- Authors
- Rabbany, S. Y., & Rafii, S.
- Affiliations
- Hofstra University (US)
- Corresponding author
- Rabbany, Sina Y.
- Rafii, Shahin
- Venue
- Nature
- Published
- 2018-09-26
- Volume
- 562
- Issue
- 7725
- Pages
- 42-43
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2892712541
- Semantic Scholar
- 21c3b787037eaa66dcba1c2a0b6ca4fb9162fca8
- Cited by
- 10
- References
- 11
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 1 · 2018: 1
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver growth, mechanotransduction, biomechanical forces, endothelial cells, mechanosensitive proteins, hepatocyte proliferation, liver regeneration, vascular biomechanics
- MeSH terms
- Hemodynamics, Liver, Integrin beta1
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