The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Statistical pitfalls of personalized medicine
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“This flawed approach fails to take into account the complexity of neurobehavioural disorders in 3 ways.9,34–37”
From Precision clinical trials: a framework for getting to precision medicine for neurobehavioural disorders (2021) · cites this paper as [34]
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“First, patient subgroups are defined by baseline pre-randomization markers that are hypothesized to modulate the effect size of the intervention (i.e., modulators), an approach commonly used in cardiovascular disease, for example.”
From Precision clinical trials: a framework for getting to precision medicine for neurobehavioural disorders (2021) · cites this paper as [34]
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Cites
An Assessment of Clinically Useful Measures of the Consequences of Treatment
Laupacis, A., Sackett, D. L., & Roberts, R. S. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806303182605 · Cited by 1,681
Personalized medicine: Time for one-person trials
Schork, N. J. (2015) · Nature · doi:10.1038/520609a · Cited by 1,274
Estimation of the Percentage of US Patients With Cancer Who Benefit From Genome-Driven Oncology
Marquart, J. P., Chen, E. Y.-S., & Prasad, V. K. (2018) · JAMA Oncology · doi:10.1001/jamaoncol.2018.1660 · Cited by 386
Consequences of dichotomization
Fedorov, V., Mannino, F., & Zhang, R. (2009) · Pharmaceutical Statistics · doi:10.1002/pst.331 · Cited by 303
Mastering variation: Variance components and personalised medicine
Senn, S. (2016) · Statistics in Medicine · doi:10.1002/sim.6739 · Cited by 205
Self-citationGralnek, I. M., Dulai, G. S., Fennerty, M. B., & Spiegel, B. M. R. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.09.013 · Cited by 198
Individual response to treatment: is it a valid assumption?
Senn, S. J. (2004) · BMJ · doi:10.1136/bmj.329.7472.966 · Cited by 185
Self-citationPortenoy, R. K., Burton, A. W., Gabrail, N. Y., & Taylor, D. R. (2010) · Pain · doi:10.1016/j.pain.2010.07.028 · Cited by 155
Labenz, J., Armstrong, D., Lauritsen, K., Katelaris, P., Schmidt, S., Schütze, K., Wallner, G. T., Juergens, H., Preiksaitis, H. G., Keeling, N., et al. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02368.x · Cited by 146
Understanding Variation in Sets of N-of-1 Trials
Araújo, A., Julious, S. A., & Senn, S. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167167 · Cited by 81
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Axes of a revolution: challenges and promises of big data in healthcare
Shilo, S., Rossman, H., & Segal, E. (2020) · Nature Medicine · doi:10.1038/s41591-019-0727-5 · Cited by 370
The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma
Zaman, S. J., Wasfy, J. H., Kapil, V., Ziaeian, B., Parsonage, W. A., Sriswasdi, S., Chico, T., Capodanno, D., Colleran, R., Sutton, N. R., et al. (2025) · The Lancet · doi:10.1016/s0140-6736(25)00055-8 · Cited by 236
Interpretation of chronic pain clinical trial outcomes: IMMPACT recommended considerations
Smith, S. M., Dworkin, R. H., Turk, D. C., McDermott, M. P., Eccleston, C., Farrar, J. T., Rowbotham, M. C., Bhagwagar, Z., Burke, L. B., Cowan, P., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000001952 · Cited by 194
“6201).(106) For additional reading on the limitations of NNTs, see also Refs.”
BackgroundHolmes, M. V., Richardson, T. G., Ference, B. A., Davies, N. M., & Davey Smith, G. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00493-1 · Cited by 184
Berenbaum, F., Blanco, F. J., Guermazi, A., Miki, K., Yamabe, T., Viktrup, L., Junor, R., Carey, W., Brown, M. T., West, C. R., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-216296 · Cited by 180
Metadata
- Authors
- Senn, S.
- Affiliations
- Luxembourg Institute of Health (LU)
- Corresponding author
- Senn, Stephen
- ORCID
- Senn, Stephen
- Venue
- Nature
- Published
- 2018-11-27
- Volume
- 563
- Issue
- 7733
- Pages
- 619-621
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2903127325
- Cited by
- 174
- References
- 12
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 18 · 2023: 23 · 2022: 18 · 2021: 38 · 2020: 28 · 2019: 22
- FWCI
- 18.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- personalized medicine, drug trials, terminology, statistical pitfalls, personalized treatment, clinical trial design
- MeSH terms
- Clinical Protocols, Clinical Trials as Topic, Humans, Statistics as Topic, Reproducibility of Results, Treatment Outcome, Evidence-Based Medicine, Precision Medicine
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