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‘It will change everything’: DeepMind’s AI makes gigantic leap in solving protein structures
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“AlphaFold has combined numerous deep learning innovations to predict the three-dimensional (3D) structures of proteins at or near experimental scale resolution”
From AlphaFold, Artificial Intelligence (AI), and Allostery (2022) · cites this paper as [3]
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Daniels, M., & Chang, B. (2021) · doi:10.51593/20210016 · Cited by 6
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“AlphaFold, developed by DeepMind, a subsidiary of Google, is an artificial intelligence (AI) system [19 ‒ 23].”
BackgroundNeuropsychopharmacology in the era of artificial intelligence and biomolecule prediction software
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“Protein remote homology detection is the first step in many state-of-the-art protein structure prediction methods, such as AlphaFold 2 [2].”
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Kaluza, M. C. D. P., Ramola, R., Joshi, P., Piovesan, D., Reade, W., Orchard, S. E., Martin, M. J., Ignatchenko, A., Rost, B., Orengo, C. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.27.716980 · Cited by 5
“The Critical Assessment of protein Structure Prediction (CASP) was the first such effort in molecular biology [23] and has recently led to remarkable developments in 3D structure prediction [34, 35, 8, 21].”
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“In the scientific context, the most recent example is the success of the AI system “AlphaFold” in predicting the folded structure of proteins based on their amino-acid sequence (Callaway, 2020; Jumper et al., 2021).”
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“…and with a view towards changes over time going forward, Google-owned DeepMind Technologies has developed an AI program known as AlphaFold which has recently outstripped numerous others in an annual competition to accurately predict the three dimensional shapes of proteins (Callaway, 2020).”
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“The recent success of AlphaFold in predicting protein structure from primary amino acid sequence has been hailed as one of the most important accomplishments in science in the past half century [27, 61, 111].”
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“Illustrative of this development is DeepMind’s program AlphaFold, which can predict the shape of almost all proteins based on their amino-acid sequences (Callaway, 2020).”
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“Recent success in solving the protein folding problem (Callaway 2020) bodes well for the eventual ability to predict kinetic parameters.”
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“The outstanding performance of AlphaFold2 at the 2020 CASP 14 competition suggests that such architectures can solve a large portion of the protein structure prediction problem [9, 10, 11].”
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“For instance, the protein folding problem has effectively been solved by training artificial neural networks to predict folded forms from primary structures (Callaway 2020).”
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“…the plant’s endogenous metabolic response to viral challenge with the potential for inhibiting a critical viral component, leveraging a reliably predicted Rep structure using AlphaFold2 (Varadi and Velankar 2022; Callaway 2020; Pereira et al. 2021; Holcomb et al. 2023; Scardino et al. 2022 ).”
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“More recently, these neural networks were successful in solving protein folding problems [8].”
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Metadata
- Authors
- Callaway, E.
- Corresponding author
- Callaway, Ewen
- Venue
- Nature
- Published
- 2020-11-30
- Volume
- 588
- Issue
- 7837
- Pages
- 203-204
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W3108943181
- Cited by
- 499
- References
- 0
- Citations by year
- 2026: 15 · 2025: 39 · 2024: 77 · 2023: 87 · 2022: 97 · 2021: 181 · 2020: 2
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
- Keywords
- DeepMind, AlphaFold, protein structure prediction, protein 3D structure, deep learning, artificial intelligence in biology, protein folding
- MeSH terms
- Deep Learning, Models, Molecular, Protein Conformation, Proteins, Time Factors, Crystallography, X-Ray, Caspases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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