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‘The entire protein universe’: AI predicts shape of nearly every known protein

Callaway, Ewen·2022·Nature

DOI 10.1038/d41586-022-02083-2

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Background
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“structures for plants, bacteria, animals, and other organisms (46).”
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Research training in an AI world
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“The program and its predicted structures for nearly all catalogued proteins with sequence information known to science are publicly available [33, 34].”
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Assessing Structural Classification Using AlphaFold2 Models Through ECOD ‐Based Comparative Analysis
Kawabata, T., & Kinoshita, K. (2025) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.26828
“The database has recently expanded to additional models, including over 200 million protein structure predictions [29].”
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“It made it possible to understand the relationships between protein functions and its 3D structures, and the results are now available to scientists in a database (Callaway, 2022).”
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Regulação da inteligência artificial na saúde
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Reflections on communication and leadership
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“If true, AlphaFold would not only predict protein structure but flexibility.”
BackgroundMethodResultInfluential
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WITHDRAWN: NMR structure verifies the eponymous zinc finger domain of transcription factor ZNF750
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Retracted
Quels enseignements de mathématiques pour la biologie ? / Which mathematics for teaching biology ?
Haiech, J. (2023) · Notes Académiques de l Académie d agriculture de France / Academic Notes of the French Academy of Agriculture · doi:10.58630/pubac.not.a244295
Animation for Science Communication: A Description of the Production Process and Contexts for Using Science Animation
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Broadening environmental research in the era of accurate protein structure determination and predictions
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Authors: Callaway, E.
Corresponding author: Callaway, Ewen
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2022-07-28
Volume: 608
Issue: 7921
Pages: 15-16
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/d41586-022-02083-2
OpenAlex: W4288428465
Cited by: 113
References: 0
Citations by year: 2026: 9 · 2025: 15 · 2024: 26 · 2023: 44 · 2022: 18
Type: other
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Machine Learning in Bioinformatics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords: AlphaFold, protein structure prediction, protein structure database, DeepMind
MeSH terms: Artificial Intelligence, Protein Conformation, Proteins, Computational Biology

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