FDA approves Alzheimer’s drug lecanemab amid safety concerns

Lecanemab in early Alzheimer's disease

van Dyck, C. H., Swanson, C. J., Aisen, P., Bateman, R. J., Chen, C., Gee, M., Kanekiyo, M., Li, D., Reyderman, L., Cohen, S., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2212948 · Cited by 5,678

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody

Swanson, C. J., Zhang, Y., Dhadda, S., Wang, J., Kaplow, J., Lai, R. Y. K., Lannfelt, L., Bradley, H., Rabe, M., Koyama, A., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-021-00813-8 · Cited by 847

Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease

Abdelrasoul, M., Yuyama, K., Swamy, M. M. M., Murai, Y., & Monde, K. (2023) · Chirality · doi:10.1002/chir.23568 · Cited by 5

Ethical Issues of Primary and Secondary Dementia Prevention

Schürmann, J. M., & Trachsel, M. (2023) · GeroPsych · doi:10.1024/1662-9647/a000321 · Cited by 5

Cross-talk between pyroptosis and miRNAs in Alzheimer disease neuropathology, therapeutic targeting of NLRP inflammasomes, and recent advances in nanoparticle-targeted therapy

Saad, H. M., Atef, E., Aboushouk, A. A., Waheeb, T. S., Elsayed, A., & Mohammed, S. A. A. (2026) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlag014 · Cited by 4

Discovery of Effective Inhibitors Against Phosphodiesterase 9, a Potential Therapeutic Target of Alzheimer’s Disease with Antioxidant Capacities

Zhou, Q., Wu, X.-N., Luo, W., Huang, Q., Feng, L., Wu, Y., & Zhang, C. (2025) · Antioxidants · doi:10.3390/antiox14020123 · Cited by 4

Inhibition of CXCR4: A perspective on miracle fruit seed for Alzheimer's disease treatment

Huang, X., Xue, L., Ma, R., Shi, J., Wang, T., Xiong, L., & Yu, C. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114841 · Cited by 5

Molecular, Translational and Clinical Research on the Two Most Common Forms of Neurodegenerative Dementia: Alzheimer’s Disease and Dementia with Lewy Bodies

Napoli, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097996 · Cited by 4

Plasma ADAM10 Levels and Their Association with Alzheimer’s Disease Diagnosis in Older Adults with Fewer Years of Formal Education

Pelegrini, L. N. D. C., da Silva, V. A., Grigoli, M. M., Vatanabe, I. P., Manzine, P. R., & Cominetti, M. R. (2024) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000538630 · Cited by 4

Beyond Structure: The Interplay of Bone and Brain During Alzheimer's Disease

Pinnamaneni, A., Akkiraju, A., Park, H. I., Ch, R. S. R., V, Ayalasomayajula, V., Bandela, M., Kaipa, S., Khosla, S., Zeineh, M., & Suryadevara, V. (2025) · Comprehensive Physiology · doi:10.1002/cph4.70075 · Cited by 2

Recent Advances in Mapping Protein Self-Assembly and Aggregation for Common Proteinopathies

Bhattacharya, S., & Thompson, D. (2024) · Acta Physica Polonica A · doi:10.12693/aphyspola.145.s37 · Cited by 3

A systematic exposure‐wide framework leveraging machine learning to identify multidomain exposure factors and their joint influence on cognitive function: Evidence from a neurological cohort

Wu, J., Yin, B., Wen, R., Pei, H., Zhu, S., Zhao, J., Li, Y., Yang, M., Hu, Y., Xu, Q., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.14624 · Cited by 2

Inhibiting the Aggregation of Aβ by Natural Product Molecules

Bai, S., Wang, Y., Li, X., & Gao, L. (2024) · ChemMedChem · doi:10.1002/cmdc.202400223 · Cited by 3

Lecanemab (Leqembi): an amyloid beta monoclonal antibody approved for the treatment of Alzheimer’s disease

Sang, Z. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23932-8.00035-2 · Cited by 3

AR-A014418-based dual Glycogen Synthase Kinase 3β/Histone Deacetylase inhibitors as potential therapeutics for Alzheimer's disease

Santini, A., Tassinari, E., Altomare, A., Loi, M., Ciani, E., Trazzi, S., Piccarducci, R., Daniele, S., Martini, C., Pagliarani, B., et al. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117838 · Cited by 5

Molecular recognition of amyloid-β oligomers in Alzheimer's disease

Jehangir, M., Xia, X., Wang, C., Hu, M., & Wang, X. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.115298 · Cited by 2

Cerebral amyloid angiopathy and Alzheimer's and related pathologies across APOE genotypes

Mehta, R. I., Wang, T., Leurgans, S. E., Bennett, D. A. A., & Schneider, J. A. (2026) · Brain · doi:10.1093/brain/awag025 · Cited by 3

Microglia–astrocyte crosstalk as a key organizing principle of Alzheimer’s disease: from homeostatic cooperation to maladaptive signaling loops

Gong, M., Lan, J. X., & Miao, J. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1908574 · Cited by 3

In Silico Analysis Reveals the Modulation of Ion Transmembrane Transporters in the Cerebellum of Alzheimer’s Disease Patients

D’Angiolini, S., Basile, M. S., Mazzon, E., & Gugliandolo, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813924 · Cited by 2

Neuroplastic and Pro-cognitive Effects of Granulocyte Colony Stimulating Factor in Healthy Adults: A Pilot Study

Wang, S., Kang, D. W., Kim, H., Park, S., & Lim, H. K. (2023) · Psychiatry Investigation · doi:10.30773/pi.2023.0150 · Cited by 2

Exploring Peptido‐Nanocomposites in the Context of Amyloid Diseases

Andrikopoulos, N., Tang, H., Wang, Y., Liang, X., Li, Y., Davis, T. P., & Ke, P. C. (2023) · Angewandte Chemie · doi:10.1002/ange.202309958 · Cited by 2

Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment

de Andrade, V. H. B., Rodrigues, E. Y. M., Dias, N. A. F., Ferreira, G. F. C., Carvalho, D. B., das Neves, A. R., Coronel, P. M. V., Yonekawa, M. K. A., Parisotto, E. B., dos Santos, E. D. A., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00443 · Cited by 2

A Novel Tetrahydroacridine Derivative with Potent Acetylcholinesterase Inhibitory Properties and Dissociative Capability against Aβ42 Fibrils Confirmed by In Vitro Studies

Mojzych, I., Zawadzka, A. M., Andrzejewski, K., Jampolska, M., Bednáriková, Z., Gančár, M., Gažová, Z., Mazur, M., & Kaczyńska, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810072 · Cited by 2

Protein aggregation in health and disease: A looking glass of two faces

de Andrade, G. C., Mota, M. F., Moreira-Ferreira, D. N., Silva, J. L., de Oliveira, G. A. P., & Marques, M. A. (2024) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2024.09.010 · Cited by 2

Eplingiella fruticosa leaf essential oil complexed with β-cyclodextrin exerts a neuroprotective effect in an Alzheimer’s disease animal model induced by Streptozotocin

Alexandre-Silva, V., Soares‐Silva, B., Pereira, G. C., Custódio‐Silva, A. C., Carvalhinho-Lopes, P. S., Taliano, L. O., Lambertucci, R. H., Duarte, M. C., Araújo, A. A. D. S., Quintans‐Júnior, L. J., et al. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01484-8 · Cited by 2

Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer’s disease

Kim, H., Yoo, S., Kwak, H., Ma, S., Kim, R., Lee, M., Ha, N., Pyo, S., Kwon, S.-G., Cho, E.-H., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01813-8 · Cited by 9

N-terminal-targeted anti-amyloid monoclonal antibodies illuminate the therapy for Alzheimer’s disease: a systematic review and comprehensive meta-analysisPreprint

Qiu, Y.-H., Liu, M., Zhan, J., Liu, L., Zheng, J., Wu, D., Wu, G., Cai, Y., & Zhang, S. (2023) · medRxiv · doi:10.1101/2023.11.20.23298794 · Cited by 2

Generation of sophisticated Alzheimer’s disease mouse models and research advances utilizing them

Hashimoto, S., & Saido, T. C. (2023) · Translational and Regulatory Sciences · doi:10.33611/trs.2023-003 · Cited by 1

Making a living moment more resonant: an exploration of the role of the artist in co-creative work with people living with dementia

West, J., Zeilig, H., Cape, T., Payne, L., & Whistler, C. (2024) · Wellcome Open Research · doi:10.12688/wellcomeopenres.19357.3 · Cited by 1

Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties

Pont, C., Sampietro, A., Pérez-Areales, F. J., Cristiano, N., Albalat, A., Pérez, B., Bartolini, M., Simone, A. D., Andrisano, V., Barenys, M., et al. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16080982 · Cited by 1

Novel Treatment Options Through Light-Based Neurostimulation

Horning, M., Aasheim, N. J., & Carstensen, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-94215-0_6 · Cited by 1

Neurology Care in the UAE

Goonetilleke, U. K. D. A. (2025) · Springer eBooks · doi:10.1007/978-981-96-0523-1_35 · Cited by 1

Treatment options for Alzheimer’s Disease: An overview of the amyloid, tau, and alternate hypotheses

Eroltu, K. (2023) · Journal of High School Science · doi:10.64336/001c.89250 · Cited by 1

Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes

Rullo, M., Spada, G. L., Brazzolotto, X., Marchese, S., Idrissi, I. G. E., Miciaccia, M., Colella, M., Brea, J. M., Macchia, E., Loza, M. I., et al. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118961 · Cited by 1

Characterization of the Anti-Alzheimer Drug Lecanemab by Mass Spectrometry

Sha, J., Geng, Z., Xue, S., Qi, S., Hu, Q., Hu, Q., Cai, M., Chen, Y., Chen, Y., Liu, S., et al. (2026) · ACS Omega · doi:10.1021/acsomega.6c02666 · Cited by 1

Alignment of human aquaporin 4 and ß‐amyloid proteins may indicate involvement of ß‐amyloid in brain water homeostasis and prevention of brain edema

Lehrer, S. P., & Rheinstein, P. H. (2023) · Chronic Diseases and Translational Medicine · doi:10.1002/cdt3.64 · Cited by 2

“If You Change the Way You Look at Things, Things You Look at Change”

Behl, C. (2023) · Springer eBooks · doi:10.1007/978-3-031-31570-1_21 · Cited by 1

Structure-based virtual screening for the inhibition and clearance of amyloidosis by small molecules as pharmacological chaperones

Sun, F., Yang, J., Sun, J., Liu, Y., Zhang, L., & Yan, J. (2023) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2023.100107 · Cited by 1

The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer’s disease

Luo, Q., Noh, J. H., & Sima, J. (2023) · Aging Research · doi:10.26599/agr.2023.9340020 · Cited by 1

A Drug Repositioning Approach Reveals Ergotamine May Be a Potential Drug for the Treatment of Alzheimer’s Disease

Wang, Q., Fu, M., Gao, L., Yuan, X., & Wang, J. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240235 · Cited by 1

Lecanemab en la enfermedad de Alzheimer: ¿realmente estamos ante un cambio en el pronóstico de la enfermedad?

Pérez-Martínez, D. A. (2023) · Revista de Neurología · doi:10.33588/rn.7606.2023055 · Cited by 1

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer’s disease

Fan, F., Joshi, P., Liu, X., Kotturu, S. K., Abiola, M., Liu, Q., & Lou, X. (2025) · doi:10.64898/2025.12.21.695860

Blocking the FAM19A5-LRRC4B complex enhances neurite growth and synapse assembly.Preprint

Seong, J. Y. (2023) · Research Square · doi:10.21203/rs.3.rs-2589038/v1

5 non-COVID vaccine recommendations from ACIP

Campos-Outcalt, D. E. (2023) · The Journal of Family Practice · doi:10.12788/jfp.0559

Meaningful improvement for patients like Tante Ilse

Barry, H. C. (2023) · The Journal of Family Practice · doi:10.12788/jfp.0562

Identification of a specific APOE transcript and functional elements associated with Alzheimer’s diseasePreprint

Chen, Q., Aguirre, L., Zhao, H., Borrego, F., de Rojas, I., Su, L., Li, P. P., Zhang, B., Kokovay, E., Lechleiter, J. D., et al. (2023) · medRxiv · doi:10.1101/2023.10.30.23297431

Is there interest of Mexican adults in being prepared should they develop Alzheimer’s or other dementia?

Marván, M. L., Castillo‐López, R. L., Onofre-Corredor, D., Vargas-Huicochea, I., & del Río, A. Á. (2023) · Salud Mental · doi:10.17711/sm.0185-3325.2023.039

A Novel Pathway Implicated in Regulating Cognitive disfunction in a Drosophila Alzheimer’s Disease Model through Acer Inhibition and CG2233 ModulationPreprint

Ghalayini, J., Lee, S. H., Gluscencova, O. B., Iliadi, K. G., & Boulianne, G. L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.21.572837

Making a living moment more resonant: an exploration of the role of the artist in co-creative work with people living with dementia

West, J., Zeilig, H., Cape, T., Payne, L., & Whistler, C. (2023) · Wellcome Open Research · doi:10.12688/wellcomeopenres.19357.1

Der Einfluss von Aβ4-42 auf die Kognition und die Anwendung von Suchstrategien im Morris Water Maze im Tg4-42-Mausmodell

Curdt, N. (2024) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-10405

Strategies for precise regulation of autophagy by traditional Chinese medicine and natural products and their application in neurodegenerative disease models

Dong, Y. J., & Lu, J. (2024) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0039

CRISPR/Cas9-based genetic engineering for translational research in neurological disorders

Megagiannis, P., Rouleau, G. A., & Zhou, Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19041-4.00021-2

Review research designed to investigate gene function and possible impact of specific variants

Smith, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23648-8.00010-3

11C-Labeling of a Flavanone Extracted from a South American Native Species for Evaluation of Its Interaction with GSK-3β

Zeni, M., Santi, M. D., Arredondo, F., Reyes, L., Bentura, M., Carvalho, D., Peralta, M. A., Ortega, M. G., Abin‐Carriquiry, J. A., Martínez‐González, L., et al. (2025) · Molecules · doi:10.3390/molecules30040874

Ar-A014418-Based Dual Glycogen Synthase Kinase 3β / Histone Deacetylases Inhibitors as Potential Therapeutics for Alzheimer's DiseasePreprint

Santini, A., Tassinari, E., Altomare, A., Loi, M., Ciani, E., Trazzi, S., Piccarducci, R., Daniele, S., Martini, C., Pagliarani, B., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5212874

Exploring an intelligent product service system for early cognitive intervention for Alzheimer’s disease

Chen, X., & Liu, S. (2025) · Universal Access in the Information Society · doi:10.1007/s10209-025-01228-0

Spectroelectrochemical Studies of Tdmq20: A Potential Drug Against Alzheimer's Disease - Part 2 - Cu-ComplexesPreprint

Wiloch, M. Z., Perez-Estebañez, M., Olmo, F., Baran, N., & Jönsson‐Niedziółka, M. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5351529

Cannabidiol improves short-term memory in a Streptozotocin-induced animal model of Alzheimer’s diseasePreprint

Pereira, G. C., Silva, V. A., Soares‐Silva, B., Taliano, L. O., Carvalhinho-Lopes, P. S., Custódio‐Silva, A. C., Silva, E., Lambertucci, R. H., Abílio, V. C., dos Santos, J. R., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7197783/v1

Reallocation of time between accelerometer-derived movement behaviors, genetic susceptibility, and risk of incident dementia, mortality, and premature death: a longitudinal cohort study

Zhang, W., Pan, Y., Dai, Y., Liang, J., Ma, J., Liu, Y., Gao, D., Zhang, Y., Ji, M., Xie, W., et al. (2025) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-025-01814-8

Spectroelectrochemical studies of TDMQ20: A potential drug against Alzheimer's disease - part 2 - Cu-complexes

Perez-Estebañez, M., Olmo, F., Baran, N., Jönsson‐Niedziółka, M., & Wiloch, M. Z. (2025) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2025.109115

Current therapies for the treatment of Alzheimer's disease

Finn, L. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-30008-0.00007-7

Additional file 2 of Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

Chen, Q., Aguirre, L., Liang, G., Zhao, H., Dong, T., Borrego, F., de Rojas, I., Hu, Q., Reyes, C., Su, L.-Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26944074

Additional file 2 of Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response

Stallings, N. R., O’Neal, M. A., Hu, J., Shen, Z.-J., & Malter, J. S. (2024) · Figshare · doi:10.6084/m9.figshare.26628040

Additional file 1 of Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response

Stallings, N. R., O’Neal, M. A., Hu, J., Shen, Z.-J., & Malter, J. S. (2024) · Figshare · doi:10.6084/m9.figshare.26628037

Additional file 3 of Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

Chen, Q., Aguirre, L., Liang, G., Zhao, H., Dong, T., Borrego, F., de Rojas, I., Hu, Q., Reyes, C., Su, L.-Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26944077

Additional file 1 of Identification of a specific APOE transcript and functional elements associated with Alzheimer’s disease

Chen, Q., Aguirre, L., Liang, G., Zhao, H., Dong, T., Borrego, F., de Rojas, I., Hu, Q., Reyes, C., Su, L.-Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26944071

Additional file 4 of Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response

Stallings, N. R., O’Neal, M. A., Hu, J., Shen, Z.-J., & Malter, J. S. (2024) · Figshare · doi:10.6084/m9.figshare.26628046

Additional file 3 of Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer’s phenotypes without blocking peripheral T cell IL-2 response

Stallings, N. R., O’Neal, M. A., Hu, J., Shen, Z.-J., & Malter, J. S. (2024) · Figshare · doi:10.6084/m9.figshare.26628043

Design and synthesis of trisubstituted 1,2,4-triazoles : structural exploration in the inhibition of GSK-3β for the treatment of Alzheimer’s disease

Pereira, T. M. (2024) · theses.fr (ABES) · doi:10.70675/f501300bz5a57z477eza236z79f3a6d2a052

„Wenn Sie die Art und Weise ändern, wie Sie Dinge betrachten, ändern sich die Dinge, die Sie betrachten“

Behl, C. (2026) · Springer eBooks · doi:10.1007/978-3-662-72210-7_21

From mechanisms to therapeutics: The expanding role of cell-based strategies in Alzheimer's disease

Sun, X., Deng, W., Yu, J., & Xu, X. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178867

Case Studies and Patents in Alzheimer’s Disease Research

Kumar, D., Anand, P., Tiwari, J., & Singh, S. N. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898814953126010016

Current Research on Alzheimer’s Disease-Associated Cognitive Disabilities Management and Future Perspectives

Das, S., Ganguly, S. C., & Kundu, M. (2026) · SpringerBriefs in modern perspectives on disability research. · doi:10.1007/978-981-95-7121-5_4

Challenges in recent Alzheimer's disease therapeutic approaches

Kim, C.-H. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45844-6.00017-2

A review on thymoquinone: a promising therapeutic molecule in Alzheimer's

Kaur, S. D., SINGH, V. A., Kaurav, H., Nangare, S., & Vihal, S. (2026) · Nutritional Neuroscience · doi:10.1080/1028415x.2026.2682949

Development of a Novel AAV-Mediated microRNA Gene Therapy for Spatial Suppression of BACE1 to Improve Cognitive Function in Alzheimer’s Disease Model Mice

Zhou, Y., Diao, Y., Yan, Z., Shui, X., Huang, Z., Sun, Y., Wang, S. W., Xia, Y., Lee, T. H., & Wang, L. (2026) · Biomolecules · doi:10.3390/biom16081075

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases

Dzib, E., Hernández‐Ayala, L. F., Silva‐Aguirre, S., & Galano, A. (2026) · ChemMedChem · doi:10.1002/cmdc.70429

Changes in evidence used for FDA Novel Drug Approvals: 2016-2024

Narayan, A. P., Irvin, V. L., Koong, A. J., Song, S. M., & Kaplan, R. M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0342878 · Cited by 1

BindingDB Entry 50021813: Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization.

BindingDB (2025) · UC San Diego · doi:10.7270/q23n2822

BindingDB Entry 50019625: Multi-target potential of newly designed tacrine-derived cholinesterase inhibitors: Synthesis, computational and pharmacological study.

BindingDB (2024) · UC San Diego · doi:10.7270/q29p361c

BindingDB Entry 50020019: Recent progress of small-molecule-based theranostic agents in Alzheimer's disease.

BindingDB (2024) · UC San Diego · doi:10.7270/q2hq44b5

BindingDB Entry 50023608: Novel tacrine-based multi-target directed Ligands: Enhancing cholinesterase inhibition, NMDA receptor antagonism, and CNS bioavailability for Alzheimer's disease treatment.

BindingDB (2026) · UC San Diego · doi:10.7270/q2pr81xz

BindingDB Entry 50020718: Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer's disease.

BindingDB (2024) · UC San Diego · doi:10.7270/q2qr52k2

BindingDB Entry 50019402: Quinolinetrione-tacrine hybrids as multi-target-directed ligands against Alzheimer's disease.

BindingDB (2024) · UC San Diego · doi:10.7270/q2sn0fb5

Alzheimer's disease: FDA approves lecanemab amid cost and safety concerns

Mahase, E. (2023) · BMJ · doi:10.1136/bmj.p73 · Cited by 43

Heralded Alzheimer’s drug works — but safety concerns loom

Prillaman, M. (2022) · Nature · doi:10.1038/d41586-022-04240-z · Cited by 9

Concerns about the approval of lecanemab for Alzheimer’s disease

Bakchine, S., Colosimo, C., Emilsson, E., Jónsdóttir, S. E., Massacesi, L., Nonino, F., Religa, D., Richard, E., Weydt, P., & Wolters, F. J. (2025) · BMJ · doi:10.1136/bmj.r778 · Cited by 7

Alzheimer’s disease: Lecanemab gets full FDA approval and black box safety warning

Mahase, E. (2023) · BMJ · doi:10.1136/bmj.p1580 · Cited by 46

New Alzheimer Drug Gains Full Approval

Aschenbrenner, D. S. (2023) · AJN American Journal of Nursing · doi:10.1097/01.naj.0000979084.89835.67