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PANTHER: A Library of Protein Families and Subfamilies Indexed by FunctionPreprint

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HDAC6 is a microtubule-associated deacetylase

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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A role for metabolism in Rett syndrome pathogenesis: New clinical findings and potential treatment targets

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Epigenetics of Hepatic Insulin Resistance

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Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

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Revealing the Complexity of a Monogenic Disease: Rett Syndrome Exome Sequencing

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HDAC3 Inhibition Promotes Antitumor Immunity by Enhancing CXCL10-Mediated Chemotaxis and Recruiting of Immune Cells

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Linking epigenetics to lipid metabolism: Focus on histone deacetylases

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NCoR1 and SMRT Play Unique Roles in Thyroid Hormone Action In Vivo

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Circadian Epigenomic Remodeling and Hepatic Lipogenesis: Lessons from HDAC3Preprint

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Integration of liver gene co-expression networks and eGWAs analyses highlighted candidate regulators implicated in lipid metabolism in pigs

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Histone Deacetylase 3 Is Required for T Cell Maturation

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The transcriptional repressor NKAP is required for the development of iNKT cells

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Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis

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Attenuation of diet-induced obesity and induction of white fat browning with a chemical inhibitor of histone deacetylases

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Histone modifications and skeletal muscle metabolic gene expression

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HDAC3 functions as a positive regulator in Notch signal transduction

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Hepatic HDAC3 Regulates Systemic Iron Homeostasis and Ferroptosis via the Hippo Signaling Pathway

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Histone deacetylases 1 and 2 regulate DNA replication and DNA repair: potential targets for genome stability-mechanism-based therapeutics for a subset of cancers

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Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases

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Role of co-regulators in metabolic and transcriptional actions of thyroid hormone

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Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis

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The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1

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HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma

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New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoR

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Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression

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The Therapeutic Potential of Class I Selective Histone Deacetylase Inhibitors in Ovarian Cancer

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The Nuclear Receptor—Co-repressor Complex in Control of Liver Metabolism and Disease

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Differential molecular mechanistic behavior of HDACs in cancer progression

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Epigenetic landscape and miRNA involvement during neural crest development

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Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1

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Emerging Role of HDACs in Regeneration and Ageing in the Peripheral Nervous System: Repair Schwann Cells as Pivotal Targets

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High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats

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Expression of class I histone deacetylases during chick and mouse development

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Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function

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Leucine-rich repeat kinase 2 exacerbates neuronal cytotoxicity through phosphorylation of histone deacetylase 3 and histone deacetylation

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Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken

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A grape seed procyanidin extract inhibits HDAC activity leading to increased Pparα phosphorylation and target‐gene expression

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Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non‑alcoholic fatty liver disease

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Regulation of Peroxisome Proliferator–Activated Receptor-γ by Angiotensin II Via Transforming Growth Factor-β1–Activated p38 Mitogen-Activated Protein Kinase in Aortic Smooth Muscle Cells

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Epigenetic Regulation of Hepatic Lipogenesis: Role in Hepatosteatosis and Diabetes

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Histone deacetylase 3 is required for iNKT cell development

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Inhibition of Glyceroneogenesis by Histone Deacetylase 3 Contributes to Lipodystrophy in Mice with Adipose Tissue Inflammation

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A SUMO-acetyl switch in PXR biology

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HDAC3 Is Required for the Downregulation of RORγt during Thymocyte Positive Selection

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Histone Deacetylase 3 Governs Perinatal Cerebral Development via Neural Stem and Progenitor Cells

Li, L., Jin, J., & Yang, X. (2019) · iScience · doi:10.1016/j.isci.2019.09.015 · Cited by 28

Histone deacetylase 11 as a key regulator of metabolism and obesity

Bhaskara, S. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.08.008 · Cited by 28

Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor

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HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4+CD8+ thymocytes for CD4-lineage commitment

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In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

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Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies

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Conditional ablation of HDAC3 in islet beta cells results in glucose intolerance and enhanced susceptibility to STZ-induced diabetes

Chen, W.-B., Gao, L., Wang, J., Wang, Y.-G., Dong, Z., Zhao, J., Mi, Q., & Zhou, L. (2016) · Oncotarget · doi:10.18632/oncotarget.11295 · Cited by 27

HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16

Liao, J., Jiang, J., Jun, H., Qiao, X., Emont, M. P., Kim, D., & Wu, J. (2018) · Endocrinology · doi:10.1210/en.2018-00257 · Cited by 27

Acetylation and deacetylation of histone in adipocyte differentiation and the potential significance in cancer

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Histone deacetylase 1 expression is inversely correlated with age in the short-lived fish Nothobranchius furzeri

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The Role of Histone Deacetylase 3 Complex in Nuclear Hormone Receptor Action

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Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator

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The Two Faces of HDAC3: Neuroinflammation in Disease and Neuroprotection in Recovery

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Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia

Min, C., Moore, N., Shearstone, J. R., Quayle, S. N., Huang, P., van Duzer, J. H., Jarpe, M. B., Jones, S. S., & Yang, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169128 · Cited by 24

Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development

Stengel, K. R., Barnett, K. R., Wang, J., Liu, Q., Hodges, E. C., Hiebert, S. W., & Bhaskara, S. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701610114 · Cited by 24

Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathologyPreprint

Enikanolaiye, A., Ruston, J., Zeng, R., Taylor, C., Schrock, M., Buchovecky, C. M., Shendure, J., Acar, E. F., & Justice, M. J. (2020) · Genome Research · doi:10.1101/gr.258400.119 · Cited by 25

MYST2 acetyltransferase expression and Histone H4 Lysine acetylation are suppressed in AML

Sauer, T., Arteaga, M. F., Isken, F., Rohde, C., Hebestreit, K., Mikesch, J., Stelljes, M., Cui, C., Zhou, F., Göllner, S., et al. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.05.010 · Cited by 23

Depletion of histone deacetylase 3 antagonizes PI3K-mediated overgrowth through the acetylation of histone H4 at lysine 16

Lv, W., Wei, H.-M., Wang, D.-L., Ni, J., & Sun, F.-L. (2012) · Journal of Cell Science · doi:10.1242/jcs.106336 · Cited by 23

Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

Kovalenko, M. V., Erdin, S., Andrew, M. A., Claire, J. S., Shaughnessey, M., Hubert, L., Neto, J. L., Stortchevoi, A., Fass, D. M., Pinto, R. M., et al. (2020) · eLife · doi:10.7554/elife.55911 · Cited by 22

Epigenetic regulation in neural crest development

Liu, Y., & Xiao, A. (2011) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20797 · Cited by 20

Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype

Ferrari, A., Longo, R., Peri, C., Coppi, L., Caruso, D., Mai, A., Mitro, N., Fabiani, E. D., & Crestani, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158594 · Cited by 21

Hepatic Mediators of Lipid Metabolism and Ketogenesis: Focus on Fatty Liver and Diabetes

Fernandes, G. W., & Bocco, B. M. L. C. (2020) · Current Diabetes Reviews · doi:10.2174/1573399816999201103141216 · Cited by 20

Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications

Panwar, A., Malik, S. O., Adib, M., & Lopaschuk, G. D. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00615.2024 · Cited by 19

The role of HDAC11 in obesity‐related metabolic disorders: A critical review

Yang, H., Chen, L., Sun, Q., Yao, F., Saeed, M., & Sun, C. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30286 · Cited by 20

The corepressor Atrophin specifies odorant receptor expression in Drosophila

Alkhori, L., Öst, A., & Alenius, M. (2013) · The FASEB Journal · doi:10.1096/fj.13-240325 · Cited by 19

Metabolism and chromatin dynamics in health and disease

Rodriguez, H., Rafehi, H., Bhave, M. R., & El‐Osta, A. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.09.004 · Cited by 18

Quality Assessment of Transcriptome Data Using Intrinsic Statistical Properties

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Peroxisome Proliferator-Activated Receptor-γ as a Target and Regulator of Epigenetic Mechanisms in Nonalcoholic Fatty Liver Disease

Zaiou, M. (2023) · Cells · doi:10.3390/cells12081205 · Cited by 17

RGFP966 Suppresses Tumor Growth and Migration Through Inhibition of EGFR Expression in Hepatocellular Carcinoma Cells in vitro

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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

Wilfahrt, D. N., Philips, R. L., Lama, J., Kizerwetter, M., Shapiro, M. J., McCue, S. A., Kennedy, M. M., Rajcula, M. J., Zeng, H., & Shapiro, V. S. (2021) · eLife · doi:10.7554/elife.70978 · Cited by 16

Development of an adverse outcome pathway for cranio-facial malformations: A contribution from in silico simulations and in vitro data

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New Insights into the Connection Between Histone Deacetylases, Cell Metabolism, and Cancer

Chiaradonna, F., Cirulli, C., Palorini, R., Votta, G., & Alberghina, L. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5854 · Cited by 16

Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study

Kim, G., Lee, S., Lee, B., Kang, E. S., Soo, B., Ferrannini, E., Lee, Y., & Cho, N. H. (2019) · Diabetologia · doi:10.1007/s00125-019-4829-x · Cited by 17

Untargeted tail acetylation of histones in chromatin: lessons from yeastThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

Friis, R. M. N., & Schultz, M. C. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-097 · Cited by 16

The role of histone deacetylases in embryonic development

Dsilva, P., Pai, P., Shetty, M. G., & Babitha, K. S. (2022) · Molecular Reproduction and Development · doi:10.1002/mrd.23659 · Cited by 15

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction

McGee‐Lawrence, M. E., White, T. A., LeBrasseur, N. K., & Westendorf, J. J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.02.001 · Cited by 15

Transcriptional co-factors and hepatic energy metabolism

Sommerfeld, A., Krones, A., & Herzig, S. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.020 · Cited by 14

Loss of Hdac3 in osteoprogenitors increases bone expression of osteoprotegerin, improving systemic insulin sensitivity

McGee‐Lawrence, M. E., Pierce, J. L., Yu, K., Culpepper, N. R., Bradley, E. W., & Westendorf, J. J. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26148 · Cited by 14

HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish

He, Y., Wang, Z., Sun, S., Tang, D., Li, W., Chai, R., & Li, H. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9433-6 · Cited by 14

Role of the histone deacetylase family in lipid metabolism: Structural specificity and functional diversity

Li, Y., Han, Q., Liu, Y., Yin, J. L., & Ma, J. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107493 · Cited by 13

Concise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation

Yang, H., Liu, Y., Liu, X., Gu, H., Zhang, J., & Sun, C. (2020) · Stem Cells International · doi:10.1155/2020/7618506 · Cited by 13

Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery

Marano, N., & Holaska, J. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1007120 · Cited by 12

Histone deacetylase functions and therapeutic implications for adult skeletal muscle metabolism

Molinari, S., Imbriano, C., Moresi, V., Renzini, A., Belluti, S., Lozanoska‐Ochser, B., Gigli, G., & Cedola, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1130183 · Cited by 12

Transcriptional repression by HDAC3 mediates T cell exclusion from Kras mutant lung tumors

McGuire, C. K., Meehan, A. S., Couser, E., Bull, L., Minor, A. C., Kuhlmann-Hogan, A., Kaech, S. M., Shaw, R. J., & Eichner, L. J. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317694121 · Cited by 12

Separation of transcriptional repressor and activator functions in Drosophila HDAC3

Tang, M., Regadas, I., Belikov, S. V., Shilkova, O., Xu, L., Wernersson, E., Liu, X., Wu, H., Bienko, M., & Mannervik, M. (2023) · Development · doi:10.1242/dev.201548 · Cited by 11

De novo missense variants in HDAC3 leading to epigenetic machinery dysfunction are associated with a variable neurodevelopmental disorder

Yoon, J. G., Lim, S.-K., Seo, H., Lee, S., Cho, J., Kim, S. Y., Koh, H. Y., Poduri, A., Ramakumaran, V. S., Vasudevan, P. C., et al. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.06.015 · Cited by 11

Lipids, LXRs and prostate cancer: Are HDACs a new link?

Hoang, J.-J., Baron, S., Volle, D. H., Lobaccaro, J. A., & Trousson, A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.04.005 · Cited by 11

Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy

López‐Rodríguez, R., Hernández‐Bartolomé, Á., Borque, M. J., Rodríguez-Muñoz, Y., Martín‐Vílchez, S., Trapero-Marugán, M., Garcı́a-Buey, L., de Rueda, P. M., Rodrigo, L., Vidal-Castiñeira, J. R., et al. (2013) · Genes and Immunity · doi:10.1038/gene.2013.24 · Cited by 11

Cutting Edge: HDAC3 Protects Double-Positive Thymocytes from P2X7 Receptor–Induced Cell Death

Philips, R. L., McCue, S. A., Rajcula, M. J., & Shapiro, V. S. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801438 · Cited by 11

The effects of Rpd3 on fly metabolism, health, and longevity

Woods, J. K., & Rogina, B. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.02.015 · Cited by 10

Rev-erbs: Integrating Metabolism Around the Clock

Lazar, M. A. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-27069-2_7 · Cited by 11

Histone Deacetylases in Metabolism: the Known and the Unexplored

Ibrahim, S. Y., Carter, J., & Bagchi, R. A. (2024) · Physiology · doi:10.1152/physiol.00044.2024 · Cited by 9

Environmental and toxicological effects of carbamate pesticides on zebrafish embryogenesis

Seomoon, K., Park, J., Song, G., & Lim, W. (2025) · Molecular & Cellular Toxicology · doi:10.1007/s13273-025-00534-1 · Cited by 9

Epigenetic regulation of oxysterol formation

Meaney, S. (2012) · Biochimie · doi:10.1016/j.biochi.2012.08.020 · Cited by 10

Histone modifications in fat metabolism and obesity

Chu, D., Thi, Y.-V. N., & Chew, N. (2023) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.01.003 · Cited by 8

Synergistic therapeutics: Co-targeting histone deacetylases and ribonucleotide reductase for enhanced cancer treatment

Shetty, M. G., Pai, P., Padavu, M., Satyamoorthy, K., & Babitha, K. S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116324 · Cited by 8

In Vivo Two-Photon Imaging Analysis of Dynamic Degradation of Hepatic Lipid Droplets in MS-275-Treated Mouse Liver

Lee, C.-G., Lee, S., Park, S., Choi, S., Song, M., Lee, H. W., Kim, H. J., KANG, Y. Y., Lee, K. W., Kim, H. M., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179978 · Cited by 7

Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity

Dávalos-Salas, M., Montgomery, M. K., Reehorst, C. M., Nightingale, R., Ng, I., Anderton, H., Al-Obaidi, S. J., Lesmana, A., Scott, C. M., Ioannidis, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13180-8 · Cited by 62

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 251

High expression of liver histone deacetylase 3 contributes to high-fat-diet-induced metabolic syndrome by suppressing the PPAR-γ and LXR-α-pathways in E3 rats

Li, D., Wang, X., Ren, W., Ren, J., Lan, X., Wang, F., Li, H., Zhang, F., Han, Y., Song, T., et al. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.028 · Cited by 37

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701

An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

Armour, S. M., Remsberg, J. R., Damle, M., Sidoli, S., Ho, W. Y., Li, Z., Garcia, B. A., & Lazar, M. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00772-5 · Cited by 69