The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia
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Polarized epithelial cells take up nutrients from the blood through receptors that are endocytosed and recycle back to the basolateral plasma membrane (PM) utilizing the epithelial-specific clathrin adaptor AP-1B. Some native epithelia lack AP-1B and therefore recycle cognate basolateral receptors to the apical PM, where they carry out important functions for the host organ. Here, we report a novel transcytotic pathway employed by AP-1B-deficient epithelia to relocate AP-1B cargo, such as transferrin receptor (TfR), to the apical PM. Lack of AP-1B inhibited basolateral recycling of TfR from common recycling endosomes (CRE), the site of function of AP-1B, and promoted its transfer to apical recycling endosomes (ARE) mediated by the plus-end kinesin KIF16B and non-centrosomal microtubules, and its delivery to the apical membrane mediated by the small GTPase rab11a. Hence, our experiments suggest that the apical recycling pathway of epithelial cells is functionally equivalent to the rab11a-dependent TfR recycling pathway of non-polarized cells. They define a transcytotic pathway important for the physiology of native AP-1B-deficient epithelia and report the first microtubule motor involved in transcytosis.
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Common recycling endosomes mediate transcytosis of the transferrin receptor and CAR from the basolateral to the apical surface in the RPE.
“Common recycling endosomes are responsible for mediating transcytosis of the transferrin receptor and the Coxsackie-adenovirus receptor (CAR) from the basolateral to the apical surface in the RPE (Diaz et al., 2009; Perez Bay et al., 2013; Perez Bay et al., 2014)”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Perez Bay et al., 2013
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BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor
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KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells
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Analysis of three μ1‐AP1 subunits during zebrafish development
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PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements
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Structural and functional analysis of endosomal compartments in epithelial cells
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- Authors
- Perez Bay, A. E., Schreiner, R., Mazzoni, F., Carvajal‐Gonzalez, J. M., Gravotta, D., Perret, E., Lehmann Mantaras, G., Zhu, Y., & Rodriguez‐Boulan, E. J.
- Affiliations
- Weill Cornell Medicine (US)
- Venue
- The EMBO Journal
- Published
- 2013-06-07
- Volume
- 32
- Issue
- 15
- Pages
- 2125-2139
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC3730227
- OpenAlex
- W2041936912
- Cited by
- 63
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 9 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 2
- FWCI
- 4.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (EY08538, R01EY008538)
- National Institute of General Medical Sciences (GM-34107, R01GM034107)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- kinesin, transcytosis, transferrin receptor, clathrin adaptor proteins, epithelial polarity, Rab11a, microtubule motor proteins, receptor trafficking, recycling endosomes
- MeSH terms
- rab11 GTP-Binding Proteins, Animals, Cricetulus, Dogs, Epithelial Cells, Cricetinae, Humans, Microtubules, Receptors, Transferrin, Endosomes, CHO Cells, Kinesins, rab GTP-Binding Proteins, Adaptor Protein Complex 1, Transcytosis, Madin Darby Canine Kidney Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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