The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Nucleolar targeting: the hub of the matter
Open accessAbstract
The nucleolus is a dynamic structure that has roles in various processes, from ribosome biogenesis to regulation of the cell cycle and the cellular stress response. Such functions are frequently mediated by the sequestration or release of nucleolar proteins. Our understanding of protein targeting to the nucleolus is much less complete than our knowledge of membrane‐spanning translocation systems—such as those involved in nuclear targeting—and the experimental evidence reveals that few parallels exist with these better‐characterized systems. Here, we discuss the current understanding of nucleolar targeting, explore the types of sequence that control the localization of a protein to the nucleolus, and speculate that certain subsets of nucleolar proteins might act as hub proteins that are able to bind to multiple protein targets. In parallel to other subnuclear structures, such as PML bodies, the proteins that are involved in the formation and maintenance of the nucleolus are inexorably linked to nucleolar trafficking.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins
Lam, Y. W., Lamond, A. I., Mann, M., & Andersen, J. S. (2007) · Current Biology · doi:10.1016/j.cub.2007.03.064 · Cited by 369
Cellular stress and nucleolar function
Mayer, C., & Grummt, I. (2005) · Cell Cycle · doi:10.4161/cc.4.8.1925 · Cited by 233
Cited by
Boulon, S., Westman, B. J., Hutten, S., Boisvert, F.-M., & Lamond, A. I. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.024 · Cited by 1,103
Emmott, E., Munday, D., Bickerton, E., Britton, P., Rodgers, M. A., Whitehouse, A., Zhou, E.-M., & Hiscox, J. A. (2013) · Journal of Virology · doi:10.1128/jvi.00321-13 · Cited by 93
Self-citationQuantitative Proteomic Analysis of A549 Cells Infected with Human Respiratory Syncytial Virus
Munday, D. C., Emmott, E., Surtees, R., Lardeau, C.-H., Wu, W., Duprex, W. P., Dove, B. K., Barr, J. N., & Hiscox, J. A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.001859 · Cited by 92
Self-citationKodiha, M., Salimi, A., Wang, Y. M., & Stochaj, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088087 · Cited by 29
Metadata
- Authors
- Emmott, E., & Hiscox, J. A.
- Venue
- EMBO reports
- Published
- 2009-02-20
- Volume
- 10
- Issue
- 3
- Pages
- 231-238
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2107405224
- Cited by
- 268
- References
- 2
- FWCI
- 10.20
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Nucleolar targeting: the hub of the matter. https://app.cochat.ai/papers/10.1038/embor.2009.14
- The paper
- Emmott, E., & Hiscox, J. A. (2009). Nucleolar targeting: the hub of the matter. EMBO reports. https://doi.org/10.1038/embor.2009.14
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
