The nucleolus under stress
Open accessAbstract
Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. Stress also often leads to reorganization of nuclear architecture, reflecting the simultaneous inhibition of major nuclear pathways (e.g., replication and transcription) and activation of specific stress responses (e.g., DNA repair). In this review, we focus on how two nuclear organelles, the nucleolus and the Cajal body, respond to stress. The nucleolus senses stress and is a central hub for coordinating the stress response. We review nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress. Crosstalk between nucleoli and CBs is also discussed in the context of stress responses.
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Nucleolar targeting of coilin is regulated by its hypomethylation state
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Drosophila Cajal bodies: accessories not included
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Flagged first, then by citations
Cited by
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Importin 7 and Exportin 1 Link c-Myc and p53 to Regulation of Ribosomal Biogenesis
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Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis
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HIF-dependent and reversible nucleosome disassembly in hypoxia-inducible gene promoters
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Muñoz López, M., López-Gil, J. F., Ramírez de la piscina Viúdez, X., Baz-Valle, E., & Tornero Aguilera, J. F. (2026) · Cells · doi:10.3390/cells15111041 · Cited by 1 · see citing works
“For advanced Q1 research, 2D surface area measurements must transition toward volumetric 3D analysis using confocal or super-resolution microscopy (e.g., STED or STORM) to accurately quantify the expansion of the nucleolar volume [54].”
Influential
- Authors
- Boulon, S., Westman, B. J., Hutten, S., Boisvert, F.-M., & Lamond, A. I.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Lamond, Angus I.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 40
- Issue
- 2
- Pages
- 216-227
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC2987465
- OpenAlex
- W1999962568
- Cited by
- 1,103
- References
- 112
- Citations by year
- 2026: 61 · 2025: 64 · 2024: 86 · 2023: 72 · 2022: 67 · 2021: 74 · 2020: 65 · 2019: 100 · 2018: 76 · 2017: 74 · 2016: 66 · 2015: 64 · 2014: 74 · 2013: 62 · 2012: 51
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Funders
- Wellcome Trust (073980, 083524/Z/07/Z)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- nucleolus, Cajal bodies, cellular stress response, p53 regulation, nucleolar morphology, nuclear organization, DNA repair, cell cycle arrest, apoptosis
- MeSH terms
- Animals, Cell Nucleolus, Cell Nucleus, DNA Repair, Humans, Models, Biological, Stress, Physiological, Signal Transduction, Tumor Suppressor Protein p53, Coiled Bodies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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