Cited by 1,103Nuclear Structure and FunctionRNA Research and SplicingGenomics and Chromatin Dynamics

The nucleolus under stress

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Boulon, Séverine, Westman, Belinda J., Hutten, Saskia, Boisvert, François-Michel, Lamond, Angus I.·2010·Molecular Cell

Abstract

Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. Stress also often leads to reorganization of nuclear architecture, reflecting the simultaneous inhibition of major nuclear pathways (e.g., replication and transcription) and activation of specific stress responses (e.g., DNA repair). In this review, we focus on how two nuclear organelles, the nucleolus and the Cajal body, respond to stress. The nucleolus senses stress and is a central hub for coordinating the stress response. We review nucleolar function in the stress-induced regulation of p53 and the specific changes in nucleolar morphology and composition that occur upon stress. Crosstalk between nucleoli and CBs is also discussed in the context of stress responses.

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Crossref · 10.1016/j.molcel.2010.09.024

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Authors
Boulon, S., Westman, B. J., Hutten, S., Boisvert, F.-M., & Lamond, A. I.
Affiliations
University of Dundee (GB)
Corresponding author
Lamond, Angus I.
Venue
Molecular Cell
Publisher
Elsevier BV
Published
2010-10
Volume
40
Issue
2
Pages
216-227
ISSN
1097-2765 (ISSN-L)
OpenAlex
W1999962568
Cited by
1,103
References
112
Citations by year
2026: 61 · 2025: 64 · 2024: 86 · 2023: 72 · 2022: 67 · 2021: 74 · 2020: 65 · 2019: 100 · 2018: 76 · 2017: 74 · 2016: 66 · 2015: 64 · 2014: 74 · 2013: 62 · 2012: 51
FWCI
4.46
Type
journal article
Language
en
Open access
Locations
  • Molecular Cell (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Discovery Research Portal (University of Dundee) (submittedVersion)
Funders
Wellcome Trust (073980, 083524/Z/07/Z)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
nucleolus, Cajal bodies, cellular stress response, p53 regulation, nucleolar morphology, nuclear organization, DNA repair, cell cycle arrest, apoptosis
MeSH terms
Animals, Cell Nucleolus, Cell Nucleus, DNA Repair, Humans, Models, Biological, Stress, Physiological, Signal Transduction, Tumor Suppressor Protein p53, Coiled Bodies

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