Five dysfunctional telomeres predict onset of senescence in human cells

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Items 101–200 of 228

  1. A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds
    Erica Salvati, Angela Rizzo, Sara Iachettini, Pasquale Zizza, Chiara Cingolani, Carmen D’Angelo, Manuela Porru, Chiara Mondello, Aurora Aiello, Antonella Farsetti et al. · 2015 · Nucleic Acids Research
  2. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
    Yifan Wang, Qikai Xu, Laura Magill Sack, Chanhee Kang, Stephen Joseph Elledge · 2016 · Genes & Development
  3. What telomeres teach us about MS
    Annalise E. Miner, Jennifer Graves · 2021 · Multiple Sclerosis and Related Disorders
  4. The multistep path to replicative senescence onset: zooming on triggering and inhibitory events at telomeric DNA
    Paolo Pizzul, Carlo Rinaldi, Diego Bonetti · 2023 · Frontiers in Cell and Developmental Biology
  5. Transcriptome analysis of papillary thyroid cancer harboring telomerase reverse transcriptase promoter mutation
    Ming-Nan Chien, Po‐Sheng Yang, Yi‐Chiung Hsu, Tsang‐Pai Liu, Jie-Jen Lee, Shih‐Ping Cheng · 2018 · Head & Neck
  6. Polymerase η suppresses telomere defects induced by DNA damaging agents
    Hannah Pope-Varsalona, Fujun Liu, Lynda J. Guzik, Patricia Lynn Opresko · 2014 · Nucleic Acids Research
  7. Cell cycle arrest in replicative senescence is not an immediate consequence of telomere dysfunction
    M.Shamim Nassrally, Ashley Lau, Katherine Wise, Noah John, Sanjeev Kotecha, Kar Lai Lee, Robert F. Brooks · 2019 · Mechanisms of Ageing and Development
  8. Single-molecule analysis of subtelomeres and telomeres in Alternative Lengthening of Telomeres (ALT) cells
    Heba Zuhair Abid, Jennifer McCaffrey, Kaitlin Raseley, ELEANOR A. YOUNG, Katy A. Lassahn, Dharma T. Varapula, Harold C. Riethman, Ming Xiao · 2020 · BMC Genomics
  9. GSK3 inhibition rescues growth and telomere dysfunction in dyskeratosis congenita iPSC-derived type II alveolar epithelial cells
    Rafael Jesus Fernandez, Zachary Gardner, Katherine J. Slovik, Derek C. Liberti, Katrina N. Estep, Wenli Yang, Qijun Chen, Garrett T. Santini, Javier Vasconcelos Perez, Sarah Root et al. · 2022 · eLife
  10. Knockdown of telomeric repeat binding factor 2 enhances tumor radiosensitivity regardless of telomerase status
    Xiaoxi Yang, Zheng Li, Lei Yang, Lei Han, Haijun Yu, Zhengkai Liao, Fuxiang Zhou, Conghua Xie, Yunfeng Zhou · 2015 · Journal of Cancer Research and Clinical Oncology
  11. Telomere Trimming and DNA Damage as Signatures of High Risk Neuroblastoma
    Eun Young Yu, Irene Y. Cheung, Yi Feng, Mohamed O. Rabie, Gail J. Roboz, Mónica L. Guzmán, Nai‐Kong V. Cheung, Neal F. Lue · 2019 · Neoplasia
  12. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts
    Mariarosaria De Rosa, Ryan P. Barnes, Ariana C. Detwiler, Prasanth R. Nyalapatla, Peter Wipf, Patricia Lynn Opresko · 2025 · Nature Communications
  13. Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases
    Tsz Wai Chu, Deanna MacNeil, Chantal Autexier · 2016 · Journal of Biological Chemistry
  14. Association of telomere instability with senescence of porcine cells
    Guangzhen Ji, Kai Liu, Maja Okuka, Na Liu, Lin Liu · 2012 · BMC Cell Biology
  15. DNA damage and aging on hematopoietic stem cells: Impact of oxidative stress in ApoE−/− mice
    Rafaela Aires, Marcella L. Porto, Letícia Montanha de Assis, P.A.N. Pereira, Glaucimeire Rocha Carvalho, Larissa Zambom Côco, Elisardo C. Vasquez, Thiago de Melo Costa Pereira, Bianca Prandi Campagnaro, Silvana S. Meyrelles · 2021 · Experimental Gerontology
  16. Mitosis, double strand break repair, and telomeres: A view from the end
    Anthony J. Cesare · 2014 · BioEssays
  17. Telomere analysis using 3D fluorescence microscopy suggests mammalian telomere clustering in hTERT-immortalized Hs68 fibroblasts
    Nancy Adam, Erin Degelman, Sophie Briggs, Rima M. Wazen, Pina Colarusso, Karl T. Riabowol, Tara L. Beattie · 2019 · Communications Biology
  18. NHP2 downregulation counteracts hTR‐mediated activation of the DNA damage response at ALT telomeres
    Maya Raghunandan, Dan Geelen, Eva Majerová, Anabelle Decottignies · 2021 · The EMBO Journal
  19. Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence
    Sabrina Ghadaouia, Marc‐Alexandre Olivier, Aurélie Martinez, Tibila Kientega, Qin Jian, Patrick Lambert-Lanteigne, Guillaume B. Cardin, Chantal Autexier, Nicolas Malaquin, Françis Rodier · 2021 · Nucleic Acids Research
  20. The Deadbeat Paternal Effect of Uncapped Sperm Telomeres on Cell Cycle Progression and Chromosome Behavior in Drosophila melanogaster
    Takuo Yamaki, Glenn K. Yasuda, Barbara T. Wakimoto · 2016 · Genetics
  21. Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen
    Alexander Stuart, Kaori Takai, Railia R Gabbasova, Henry Sanford, Ekaterina V. Vinogradova, Titia de Lange · 2025 · Molecular Cell
  22. Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis
    Elisa Gobbini, Camilla Trovesi, Corinne Cassani, Maria Pia Longhese · 2014 · Molecular & Cellular Oncology
  23. A mechanism for telomere-specific telomere length regulation
    Gabriela Maia Teplitz, Emeline Pasquier, Erin Bonnell, Evelina De Laurentiis, Louise Bartle, Jean‐François Lucier, Gabriel St-Laurent, Dean S Dawson, Raymund J. Wellinger · 2025 · Nucleic Acids Research
  24. A regulatory loop connecting WNT signaling and telomere capping: possible therapeutic implications for dyskeratosis congenita
    Rafael Jesus Fernandez, F Brad Johnson · 2018 · Annals of the New York Academy of Sciences
  25. A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae
    Pascale Jolivet, Kamar Serhal, Marco Graf, Stephan Eberhard, Zhou Xu, Brian Luke, Maria Teresa Teixeira · 2019 · Scientific Reports
  26. Telomere Interacting Proteins and TERRA Regulation
    Lara Pérez‐Martínez, Tina Wagner, Brian Luke · 2022 · Frontiers in Genetics
  27. RETRACTED: A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells
    Joydeep Mukherjee, Ajay Pandita, Kamalakar Chatla, Tor-Christian Aase Johannessen, Shigeo Ohba, Yongjian Tang, Cecilia L. Dalle Ore, Rolf Bjerkvig, Russell O. Pieper · 2021 · Science Translational Medicine · Retracted
  28. γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue
    Alexander Orenstein, April S. Berlyoung, Elizabeth E. Rastede, Ha Pham, Elise Fouquerel, Connor Murphy, Brian J. Leibowitz, Jian Yu, Tumul Srivastava, Bruce A. Armitage et al. · 2017 · Molecules
  29. Fluorescence spectroscopic detection and measurement of single telomere molecules
    Cyrus Weijie Beh, Ye Zhang, Yun‐Ling Zheng, Bing Sun, Tza‐Huei Wang · 2018 · Nucleic Acids Research
  30. Recombinogenic Telomeres in Diploid Sorex granarius (Soricidae, Eulipotyphla) Fibroblast Cells
    N. S. Zhdanova, Irena Drašković, Julia M. Minina, Tatyana V. Karamysheva, Clara Lopes Novo, Win-Yan Liu-Bordes, Rosa María Porreca, Anne Gibaud, Maria I. Zvereva, Dmitry Aleksandrovich Skvortsov et al. · 2014 · Molecular and Cellular Biology
  31. To senesce or not to senesce: how primary human fibroblasts decide their cell fate after DNA damage
    Gabriel Kollárovič, Maja Studencka‐Turski, Lyubomira Ivanova, Claudia Lauenstein, Kristina Heinze, Anastasiya Lapytsko, Soheil Rastgou Talemi, Ana Sofia Figueiredo, Jörg Schaber · 2016 · Aging
  32. Phosphorothioate-modified antisense oligonucleotides against human telomerase reverse transcriptase sensitize cancer cells to radiotherapy
    Fei Cao, Xiaoping Ju, Di Chen, Lingong Jiang, Xiaofei Zhu, Shuiwang Qing, Fang Fang, Yuxin Shen, Zhen Jia, Huojun Zhang · 2017 · Molecular Medicine Reports
  33. Mild Telomere Dysfunction as a Force for Altering the Adaptive Potential of Subtelomeric Genes
    Jennifer M. O. Mason, Michael J. McEachern · 2017 · Genetics
  34. Telomere Crisis Shapes Cancer Evolution
    Joe Nassour, Jan Karlseder · 2025 · Cold Spring Harbor Perspectives in Biology
  35. Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere Shortening
    Barnes, Ryan P., de Rosa, Mariarosaria, Thosar, Sanjana A., Detwiler, Ariana C., Roginskaya, Vera, Van Houten, Bennett, Bruchez, Marcel P., Stewart-Ornstein, Jacob, Opresko, Patricia L. · 2021
  36. Single-molecule telomere length characterization by optical mapping in nano-channel array: Perspective and review on telomere length measurement
    Lahari Uppuluri, Dharma T. Varapula, Eleanor Young, Harold C. Riethman, Ming Xiao · 2020 · Environmental Toxicology and Pharmacology
  37. Senescence‐associated transcriptional derepression in subtelomeres is determined in a chromosome‐end‐specific manner
    Martin Rey‐Millet, Mélanie Pousse, Chan Soithong, Jing Ye, Aarón Méndez-Bermúdez, Éric Gilson · 2023 · Aging Cell
  38. OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence
    Mariarosaria De Rosa, Ryan P. Barnes, Prasanth R. Nyalapatla, Peter Wipf, Patricia Lynn Opresko · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Advances in biomarkers and diagnostic significance of organ aging
    Yulin Chen, Jiadong Li, Xinru Liu, Zhen Geng, Ke Xu, Jiacan Su · 2023 · Fundamental Research
  40. Impaired telomere pathway and fertility in Senescence-Accelerated Mice Prone 8 females with reproductive senescence
    Alba María Polonio, Marta Medrano, Lucía Chico-Sordo, Isabel Córdova-Oriz, Mauro Cozzolino, José Montáns, Sonia Herraiz, Emre U Seli, António Pellicer, Juan Antonio García-Velasco et al. · 2023 · Aging
  41. Contributions of Telomere Biology to Human Age-Related Disease
    Ting-Lin Yang, Shufei Song, F Brad Johnson · 2015 · Elsevier eBooks
  42. The Role of Chromatin Reorganization in the Process of Cellular Senescence
    Kaoru Tominaga, Olivia M. Pereira‐Smith · 2012 · Current Drug Targets
  43. Generation of Immortalised But Unstable Cells after hTERT Introduction in Telomere-Compromised and p53-Deficient vHMECs
    Aina Bernal, Elisenda Zafon, Daniel Domínguez, Enric Bertran, Laura Tusell · 2018 · International Journal of Molecular Sciences
  44. A CPC-shelterin-BTR axis regulates mitotic telomere deprotection
    Diana Romero‐Zamora, Samuel Rogers, Ronnie Ren Jie Low, Scott G. Page, Blake J. E. Lane, Shunya Kosaka, Andrew B. Robinson, Lucy French, Noa Lamm, Fuyuki Ishikawa et al. · 2025 · Nature Communications
  45. Telomere instability initiates and then boosts carcinogenesis by the butterfly effect
    Cécile Hérate, Laure Sabatier · 2020 · Current Opinion in Genetics & Development
  46. Low Antioxidant Glutathione Levels Lead to Longer Telomeres: A Sex-Specific Link to Longevity?
    A. Romero-Haro, J. Figuerola, C. Alonso-Alvarez · 2023 · Integrative Organismal Biology
  47. Telomere recombination in normal mammalian cells
    N. S. Zhdanova, Н. Б. Рубцов · 2016 · Russian Journal of Genetics
  48. Single telomere length analysis in Ustilago maydis, a high-resolution tool for examining fungal telomere length distribution and C-strand 5’-end processing
    Ganduri Swapna, Eun Young Yu, Neal F. Lue · 2018 · Microbial Cell
  49. Heterogeneity of Cellular Senescence: Subtype‐Specific Mechanisms and the Emerging Role of Plasma Membrane Damage
    Enaam Alghamdi, Keiko Kono · 2025 · Cancer Science
  50. Replicative senescence induction in single cells is not predicted by telomere length, dysfunction, or oxidation
    Victor J. Passanisi, Sabrina L. Spencer · 2026 · iScience
  51. A persistent variant telomere sequence in a human pedigree
    Angela M. Hinchie, Samantha L. Sanford, Kelly E. Loughridge, Rachel M. Sutton, Anishka H. Parikh, Agustin A. Gil Silva, Daniel I. Sullivan, Pattra Chun‐on, Matthew R. Morrell, John F. McDyer et al. · 2024 · Nature Communications
  52. Telomere length distribution on individual chromosome arms in patients with bronchial asthma
    Margarita Sh. Barkovskaya, Elena A. Blinova, J. V. Konyahina, M. I. Leonova, V. M. Nepomniashchikch, Д. В. Демина, Vladimir S. Kozhevnikov, Kozlov Va · 2019 · Bulletin of Siberian Medicine
  53. Inorganic elements in occupational settings: A review on the effects on telomere length and biology
    Vivian Francília Silva Kahl, Juliana da Silva · 2021 · Mutation Research/Genetic Toxicology and Environmental Mutagenesis
  54. Long telomeres: too much of a good thing
    Michael Chang · 2012 · BioMolecular Concepts
  55. Telomere Dynamics in Human Health and Disease
    Duncan M. Baird · 2024 · Cold Spring Harbor Perspectives in Biology
  56. Both genome instability and replicative senescence stem from the shortest telomere in telomerase-negative cells
    Prisca Berardi, Veronica Martinez-Fernandez, Anaïs Rat, Fernando Rodrigo Rosas Bringas, Pascale Jolivet, Rachel E. Langston, Stefano Mattarocci, Alexandre Maes, Théo Aspert, Bechara Zeinoun et al. · 2026 · Nature Communications
  57. Telomeric dysfunction triggers an unstable growth arrest leading to irreparable genomic lesions and entry into cellular senescence
    Sabrina Ghadaouia, Marc‐Alexandre Olivier, Aurélie Martinez, Nicolas Malaquin, Guillaume B. Cardin, Françis Rodier · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  58. T-loop dynamics: telomere structure shapes cell fate decisions
    Makoto Hayashi, Anthony J. Cesare · 2026 · Trends in Cell Biology
  59. A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection
    Diana Romero‐Zamora, Makoto Hayashi · 2023 · Scientific Reports
  60. Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells
    Alexander P. Sobinoff, Salvatore Di Maro, Ronnie Ren Jie Low, Rosaria Benedetti, Stefano Tomassi, Antonia D’Aniello, Rosita Russo, Ilaria Baglivo, Ugo Chianese, Paolo V. Pedone et al. · 2023 · Cell chemical biology
  61. Cell Cycle Checkpoints and Senescence
    Renu Wadhwa, Zeenia Kaul, Sunil C. Kaul · 2016 · Healthy ageing and longevity
  62. The Role of Microhomology-Mediated End Joining (MMEJ) at Dysfunctional Telomeres
    David L. Billing, Agnel J. Sfeir · 2024 · Cold Spring Harbor Perspectives in Biology
  63. Life and Death without Telomerase: The Saccharomyces cerevisiae Model
    Veronica Martinez-Fernandez, Aurélia Barascu, Maria Teresa Teixeira · 2024 · Cold Spring Harbor Perspectives in Biology
  64. The Role of Telomeres in Senescence, Aging and Disease: Fiction and Reality
    Gabriele Christine Saretzki · 2025 · OBM Geriatrics
  65. GPCR systems coordinate cellular resilience against aging-associated stress
    Tabitha Boeringer, Mia Pardo, Carter J Craig, Ainhoa Nieto Gutierrez, Derek R. Duckett, Patricia H. McDonald, Stuart R. Maudsley · 2026 · Frontiers in Molecular Biosciences
  66. Analysis of Telomere Length and Aberrations by Quantitative FISH
    Elise Fouquerel, Patricia Lynn Opresko · 2020 · Methods in molecular biology
  67. Cross-talk of Three Molecular Subtypes of Telomere Maintenance Defines Clinical Characteristics and Tumor Microenvironment in Gastric Cancer
    Mengpei Yan, Zhijun Zhang, Luyao Wang, Hongxin Huang, Jihuan Wang, Chengjun Zhu, Zheng Li, Zekuan Xu · 2024 · Journal of Cancer
  68. Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells
    Aina Bernal, Marc Moltó‐Abad, Daniel Domínguez, Laura Tusell · 2018 · Oncotarget
  69. Telomere flip‐flop: an unfolding passage to senescence
    Carolyn M. Price · 2011 · EMBO Reports
  70. The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
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  71. The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence
    Gautham Yepuri, Kushie Kancharla, Riccardo Perfetti, Shoshana Shendelman, Andrew S. Wasmuth, Ravichandran Ramasamy · 2024 · Frontiers in Aging
  72. Subtelomeric elements provide stability to short telomeres in telomerase-negative cells of the budding yeast Naumovozyma castellii
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  73. Molecular mechanisms and recent advances in cellular senescence
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  74. Telomere Length Changes in Children With Cushing Disease: A Pilot Study
    Christina Tatsi, Chelsi L Flippo, Fabio Rueda Faucz, Ninet Sinaii, Constantine A. Stratakis · 2020 · Journal of the Endocrine Society
  75. Telomere Maintenance in the Dynamic Nuclear Architecture
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  76. Suppression of genomic instability by replicative senescence and crisis
    Jan Karlseder · 2020 · Genome Instability & Disease
  77. The Long Covid-19 Syndrome the Spike Protein and Stem Cells, the Underrated Role of Retrotransposons, a Working Hypothesis
    Mario Giosuè Balzanelli, Pietro Distratis, Rita Lazzaro, Gianna Dipalma, Francesco Inchingolo, Raffaele Del Prete, Van Hung Pham, Sergey Khachatur Aityan, Kieu C.D. Nguyen, Ciro Gargiulo Isacco · 2023 · Preprints.org
  78. Beginning at the ends: telomere and telomere-based cancer therapeutics
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  79. Disorders of Telomere Length
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  81. Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome
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  82. Telomeres and Chromosome Stability
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  83. Implication of Other Noncoding RNAs in Cancer
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  84. Dysfunction telomeres in embryonic fibroblasts and cultured in vitro pluripotent stem cells of Rattus norvegicus (Rodentia, Muridae)
    N. S. Zhdanova, Evgenia A Vaskova, Tatyana V. Karamysheva, Julia M. Minina, Nicolay Rubtsov, Suren M. Zakian · 2019 · Comparative Cytogenetics
  85. Identification of telomere maintenance-driven molecular subtypes in hepatocellular carcinoma: implications for prognosis and targeted therapy via KPNA2
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  86. Clonal hematopoiesis in telomere biology disorders
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  87. Telomeres Shortening: A Mere Replicometer?
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  88. Withaferin-A as a Potential Candidate for Cancer Therapy: Experimental Evidence of Its Effects on Telomerase Plus and Minus Cancer Cells
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  89. A Noncanonical Function of the Telomerase RNA Component in Human Embryonic Stem Cells
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  90. Ionizing Radiation Effects on Telomeres
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  91. Telomere length as a putative biomarker of health and disease
    Sarah L. Appleby · 2016 · Otago University Research Archive (University of Otago)
  92. The role of telomere damage in cardiomyocyte ageing
    Rhys K. Anderson · 2016
  93. Telomerase inhibition causes premature senescence of fetal guinea pig muscle cells
    Stephanie E Hallows, Timothy R.H. Regnault, Dean Harvey Betts · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  94. On a Break with the X: The Role of Repair of Double-Stranded DNA Breaks in X-Linked Disease
    Laura De Caris, Lucia Cecceroni, Hemanth Tummala · 2012 · Biotechnology & Biotechnological Equipment
  95. CARF Regulates Cellular Senescence and Apoptosis through p53-Dependent and -Independent Pathways
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  96. Structure and Functions of Telomeres in Organismal Homeostasis and Disease
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  97. Telomeres in Liver Transplantation Allografts
    Tatsuaki Tsuruyama, Wulamujiang Aini · 2016 · InTech eBooks
  98. Oncofetal HMGA2 as a key regulator of telomere stability through control of DNA topology
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  99. The role of melanocyte senescence in skin ageing
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  100. Senescence in duckweed: an interspecific comparison and the influence of temperature
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