The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya‐Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S +10 more·2011·The EMBO Reports

Cited by (1,000)

Items 901–1,000 of 1,000

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  28. DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas
    C. Mircea S. Tesileanu, Wies Vallentgoed, Marc Sanson, Walter Taal, Paul M. Clément, Wolfgang Wick, Alba Ariela Brandes, Jean Français Baurain, Olivier Louis Chinot, Helen Wheeler et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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    Arvīds Jakovļevs · 2021
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  34. Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
    J.H. Xu, Yuanyuan Hu, Xiaoqi Liu, Anhui Gao, Lixin Gao, Lei Xu, Yubo Zhou, Jianrong Gao, Qing Ye, Chunqi Hu et al. · 2021 · Pharmaceutical Chemistry Journal
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    Rati Jani, Seema Mihrshahi, Subhadra Mandalika, Kimberley Margaret Mallan · 2014 · QUT ePrints (Queensland University of Technology)
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  37. Faculty Opinions recommendation of Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
    Taina A. Pihlajaniemi · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  38. Faculty Opinions recommendation of Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
    Josef T. Prchal · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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  42. Faculty Opinions recommendation of Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo.
    Wafik S. El‐Deiry, Pieter van den Heuvel · 2012 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  43. Faculty Opinions recommendation of IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives.
    Keith Adam Choate · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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    Anna K.W. Tribe · 2023
  51. [Clinical analysis of the combination regimen with Bcl-2 inhibitor venetoclax in the treatment of 30 cases of acute myeloid leukemia with IDH1/2 mutation].
    X Wang, Xiebing Bao, J Zhang, Baoquan Song, M Y Li, Jundan Xie, Hongjie Shen, Depei Wu, Huiying Qiu · 2022 · PubMed Central
  52. Data from Hypoxia-Driven Oncometabolite L-2HG Maintains Stemness-Differentiation Balance and Facilitates Immune Evasion in Pancreatic Cancer
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  77. Additional file 3 of Targeting phosphoglycerate dehydrogenase in multiple myeloma
    Samah Elsaadi, Ida Johnsen Steiro, Abdollahi, Pegah, Esten N. Vandsemb, Yang, Rui, Tobias Schmidt Slørdahl, Torstein Baade Rø, Eline Menu, Sponaas, Anne-Marit, Magne Børset · 2021 · Figshare
  78. Additional file 20 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  79. Additional file 5 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  80. Additional file 16 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  81. Additional file 4 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  82. Additional file 19 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  83. Additional file 1 of Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
    Hsiao P. J. Voon, Linda L. Hii, Andrew Garvie, Maheshi Udugama, Brian Krug, Caterina Russo, Anderly C. Chüeh, Roger J. Daly, Alison E. Morey, Toby D. M. Bell et al. · 2023 · Figshare
  84. Additional file 2 of Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
    Hsiao P. J. Voon, Linda L. Hii, Andrew Garvie, Maheshi Udugama, Brian Krug, Caterina Russo, Anderly C. Chüeh, Roger J. Daly, Alison E. Morey, Toby D. M. Bell et al. · 2024 · Figshare
  85. Additional file 4 of Targeting phosphoglycerate dehydrogenase in multiple myeloma
    Samah Elsaadi, Ida Johnsen Steiro, Abdollahi, Pegah, Esten N. Vandsemb, Yang, Rui, Tobias Schmidt Slørdahl, Torstein Baade Rø, Eline Menu, Sponaas, Anne-Marit, Magne Børset · 2021 · Figshare
  86. Additional file 1 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2023 · Figshare
  87. Additional file 3 of Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
    Hsiao P. J. Voon, Linda L. Hii, Andrew Garvie, Maheshi Udugama, Brian Krug, Caterina Russo, Anderly C. Chüeh, Roger J. Daly, Alison E. Morey, Toby D. M. Bell et al. · 2024 · Figshare
  88. Additional file 11 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  89. Additional file 8 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  90. Additional file 13 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  91. Additional file 14 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  92. Additional file 1 of Targeting phosphoglycerate dehydrogenase in multiple myeloma
    Samah Elsaadi, Ida Johnsen Steiro, Abdollahi, Pegah, Esten N. Vandsemb, Yang, Rui, Tobias Schmidt Slørdahl, Torstein Baade Rø, Eline Menu, Sponaas, Anne-Marit, Magne Børset · 2021 · Figshare
  93. Additional file 9 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  94. Additional file 6 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  95. Additional file 15 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  96. Additional file 21 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  97. Additional file 18 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  98. Additional file 12 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  99. Additional file 17 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare
  100. Additional file 3 of A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
    Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Noberini, Roberta, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2024 · Figshare