The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya‐Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S +10 more·2011·The EMBO Reports

DOI 10.1038/embor.2011.43

Cited by (1,000)

Items 501–600 of 1,000

Cancer metabolomics in basic science perspective
Hyuk Nam Kwon, Sehyun Oh, Xing Jin, Yong An, Sunghyouk Park · 2015 · Archives of Pharmacal Research
Epigenetics in focus: Pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents
Valeria Santini, Ari M. Melnick, Jaroslaw Pawel Maciejewski, Estelle Duprez, Clara Nervi, Lucio Cocco, Kevin G. Ford, Ghulam Jeelani Mufti · 2013 · Critical Reviews in Oncology/Hematology
A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors
Mohammed Khurshed, Remco Jurriaan Molenaar, Myra Ellen Van Linde, Ron A. A. Mathôt, Eduard A. Struys, Tom van Wezel, Cornelis J.F. Van Noorden, Heinz‐Josef Klümpen, Judith V.M.G. Bovée, Johanna W. Wilmink · 2021 · Cancers
2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies
Vittoria Raimondi, Giulia Ciotti, Michele Gottardi, Francesco Ciccarese · 2022 · Biomedicines
Epidemiology, biology, and management of venous thromboembolism in gliomas: An interdisciplinary review
Jasmin Jo, María Díaz, Craig Horbinski, Nigel Mackman, Stephen Joseph Bagley, Marika Broekman, Janusz W. Rak, James Perry, Ingrid Pabinger, Nigel S. Key et al. · 2023 · Neuro-Oncology
Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients
Yoshinobu Takahashi, Hideo Nakamura, Keishi Makino, Takuichiro Hide, Daisuke Muta, Hajime Kamada, Jun‐ichi Kuratsu · 2013 · World Journal of Surgical Oncology
Integrating genetics and epigenetics in myelodysplastic syndromes: advances in pathogenesis and disease evolution
Guillermo Montalban Bravo, Elinor Lee, Brayan Merchán, Hagop M. Kantarjian, Guillermo Garcia‐Manero · 2014 · British Journal of Haematology
Enigmas of IDH mutations in hematology/oncology
Michael Heuser, Michelle Maria Araujo Cruz, Ramya Goparaju, Anuhar Chaturvedi · 2015 · Experimental Hematology
Further understanding of the pathology of glioma: implications for the clinic
Sandra Ines Camelo-Piragua, Santosh Kesari · 2016 · Expert Review of Neurotherapeutics
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53
Bin Jiang, Wentao Zhao, Minggang Shi, Jia Zhang, Ai Chen, Huanhuan Ma, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang et al. · 2018 · Journal of Biological Chemistry
Effect of itraconazole, food, and ethnic origin on the pharmacokinetics of ivosidenib in healthy subjects
David Dai, Hua Qiang Yang, Salah Nabhan, Hua Liu, Denice Kaylor Hickman, Guowen Liu, Jeffrey Zacher, Apinya Vutikullird, Chandra Prakash, Samuel V. Agresta et al. · 2019 · European Journal of Clinical Pharmacology
Epidemiology of Anthropometric Factors in Glioblastoma Multiforme—Literature Review
Donata Simińska, Jan Korbecki, Klaudyna Kojder, Patrycja Kapczuk, Marta Fabiańska, Izabela Gutowska, Anna Machoy‐Mokrzyńska, Dariusz Chlubek, Irena Baranowska‐Bosiacka · 2021 · Brain Sciences
Metabolic implications of non-electrogenic ATP/ADP exchange in cancer cells: A mechanistic basis for the Warburg effect
John J. Lemasters · 2021 · Biochimica et Biophysica Acta (BBA) - Bioenergetics
T herapeutic targeting of chromatin: status and opportunities
Marton I. Siklos, Stefan Kubicek · 2021 · FEBS Journal
Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila
Zachary J. Reitman, Sergey A. Sinenko, Eric P. Spana, Hai Yan · 2014 · Blood
Quantification of The Sixth DNA Base 5-Hydroxymethylcytosine in Colorectal Cancer Tissue and C-26 Cell Line
Zhang Liang-tao, Lijian Zhang, Junjie Zhang, Xiaoxia Ye, Ai-Mei Xie, Li‐Yu Chen, Jing Xuan Kang, Chun Cai · 2013 · Bioanalysis
Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase
Meike Hüdig, Alexander Maier, Isabell Scherrers, Laura Seidel, Erwin E. W. Jansen, Tabea Mettler‐Altmann, Martin K. M. Engqvist, Verónica Graciela Maurino · 2015 · Plant and Cell Physiology
Epigenetic Regulatory Mechanisms in Stress-Induced Behavior
Sumana Chakravarty, Salil Saurav Pathak, Swati Maitra, Nitin Khandelwal, Bhanu Chandra Karisetty, Arvind Kumar · 2014 · International review of neurobiology
Identification of specific biomarkers for gastric adenocarcinoma by ITRAQ proteomic approach
Xiaoxiao Wang, Qiaoming Zhi, Songbai Liu, Shengli Xue, Congcong Shen, Yangxin Li, Chaofan Wu, Zaixiang Tang, Weichang Chen, Jenny Lee Song et al. · 2016 · Scientific Reports
Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases
Yiwei Cao, Rui-Hong Wang · 2017 · Aging and Disease
Sirtuin activation targets IDH-mutant tumors
Julie J. Miller, Alexandria L. Fink, Jack A Banagis, Hiroaki Nagashima, Megha P. Subramanian, Christine Kyuyoung Lee, Lisa Melamed, Shilpa S. Tummala, Kensuke Tateishi, Hiroaki Wakimoto et al. · 2020 · Neuro-Oncology
Long non-coding RNA in glioma: novel genetic players in temozolomide resistance
Jungwook Roh, Mijung Im, JiHoon Kang, BuHyun Youn, Wanyeon Kim · 2023 · Animal Cells and Systems
Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1
Jason M. Law, Sebastian Stark, Ke Liu, Norah E. Liang, Mahmud M. Hussain, Matthias Leiendecker, Daisuke Ito, Oscar Verho, Andrew M. Stern, Stephen E. Johnston et al. · 2016 · ACS Medicinal Chemistry Letters
The Complex Interplay between Metabolic Reprogramming and Epigenetic Alterations in Renal Cell Carcinoma
Ana Lameirinhas, Vera Miranda‐Gonçalves, Rui Henrique, Cármen Jerónimo · 2019 · Genes
A Genome-Wide Profiling of Glioma Patients with an IDH1 Mutation Using the Catalogue of Somatic Mutations in Cancer Database
Amrit L. Pappula, Shayaan Rasheed, Golrokh Mirzaei, Ruben C. Petreaca, Renee A. Bouley · 2021 · Cancers
Isocitrate dehydrogenase gene variants in cancer and their clinical significance
Thomas A.D. Cadoux-Hudson, Christopher John Schofield, James McCullagh · 2021 · Biochemical Society Transactions
Metabolism and epigenetics: drivers of tumor cell plasticity and treatment outcomes
Benjamin N. Gantner, Flávio Romero Palma, Madhura R. Pandkar, Marcelo Jun Sakiyama, Daniel Arango, Gina M. DeNicola, Ana P. Gomes, Marcelo Gialluisi Bonini · 2024 · Trends in cancer
Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies
Matthew S. Waitkus, Hai Yan · 2020 · Clinical Cancer Research
Targeting phosphoglycerate dehydrogenase in multiple myeloma
Samah Elsaadi, Ida Johnsen Steiro, Pegah Abdollahi, Esten N. Vandsemb, Rui Ryan Yang, Tobias Schmidt Slørdahl, Torstein Baade Rø, Eline Menu, Anne‐Marit Sponaas, Magne Børset · 2021 · Experimental Hematology and Oncology
Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q
Jiao Chen, Jie Yang, Xianqiang Sun, Zhongming Wang, Xiaolan Cheng, Wuguang Lu, Xueting Cai, Chunping Hu, Xu Shen, Peng Cao · 2017 · Scientific Reports
IDH Mutations in Chondrosarcoma: Case Closed or Not?
Sanne Venneker, Judith V.M.G. Bovée · 2023 · Cancers
Oncometabolite 2-hydroxyglutarate regulates anti-tumor immunity
Mengyuan Cai, Jianyi Zhao, Qiang Ding, Jifu Wei · 2024 · Heliyon
Branched-chain α-ketoacids aerobically activate HIF1α signalling in vascular cells
Wusheng Xiao, Nishith M. Shrimali, Niv Vigder, William M. Oldham, Clary B. Clish, Huamei He, Samantha J. Wong, Bradley M. Wertheim, Elena Arons, Marcia C. Haigis et al. · 2024 · Nature Metabolism
In Vivo Modeling of Malignant Glioma
Timothy P. Kegelman, Bin Hu, Luni Emdad, Swadesh Kumar Das, Devanand Sarkar, Paul B. Fisher · 2014 · Advances in cancer research
Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair
Corina Penterling, Guido A. Drexler, Claudia Böhland, Ramona Stamp, Christina Wilke, Herbert Braselmann, Randolph B. Caldwell, Judith Reindl, Stefanie Girst, Christoph Greubel et al. · 2016 · PLoS ONE
Novel epigenetic therapies in hematological malignancies: Current status and beyond
Paolo Gallipoli, Brian J.P. Huntly · 2017 · Seminars in Cancer Biology
Role of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells
Bonnie H.Y. Yeung, Jessie Huang, Steven S. An, Julian Solway, Wayne Mitzner, Wan‐Yee Tang · 2020 · American Journal of Respiratory Cell and Molecular Biology
The physical basis and practical consequences of biological promiscuity
Shelley D. Copley · 2020 · Physical Biology
Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias
Ugo Testa, Germana Castelli, Elvira Pelosi · 2020 · Cancers
Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
Lennart Brewitz, Yu Nakashima, Christopher John Schofield · 2020 · Chemical Science
2-Hydroxyglutarate destabilizes chromatin regulatory landscape and lineage fidelity to promote cellular heterogeneity
Meena Kusi, Maryam Zand, Li‐Ling Lin, Meizhen Chen, Anthony Lopez, Chun-Lin Lin, Chiou‐Miin Wang, Nicholas L. L. Lucio, Nameer B. Kirma, Jianhua Ruan et al. · 2022 · Cell Reports
Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism‐Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu
Guangyu Hu, Zhe Cui, Xiyao Chen, Fangfang Sun, Tongzheng Li, Congye Li, Ling Zhang, Xiong Guo, Hang Zhao, Yunlong Xia et al. · 2023 · Advanced Science
Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma
Chao Sun, Liming Xiao, Yuanlin Zhao, Jiankuan Shi, Yuan Yuan, Yu Gu, Feng Zhang, Xing Gao, Ying Yang, Risheng Yang et al. · 2020 · Translational Oncology
Mutant <i>IDH</i> : A Targetable Driver of Leukemic Phenotypes Linking Metabolism, Epigenetics and Transcriptional Regulation
Garrett-Bakelman, Francine E, Melnick, Ari M · 2016 · Epigenomics
Illuminating the cross-talk between tumor metabolism and immunity in IDH-mutated cancers
Julie Leca, Jérôme Fortin, Tak W. Mak · 2020 · Current Opinion in Biotechnology
The Role of 2-Oxoglutarate Dependent Dioxygenases in Gliomas and Glioblastomas: A Review of Epigenetic Reprogramming and Hypoxic Response
Rebekah Crake, Eleanor R. Burgess, Janice A. Royds, Elisabeth Phillips, Margreet C.M. Vissers, Gabi U. Dachs · 2021 · Frontiers in Oncology
Epigenetic methylations and their connections with metabolism
Fulvio Chiacchiera, Andrea Piunti, Diego Pasini · 2013 · Cellular and Molecular Life Sciences
Pharmacokinetics, absorption, metabolism, and excretion of [14C]ivosidenib (AG-120) in healthy male subjects
Chandra Prakash, Bin Fan, Syed A. Altaf, Sam Agresta, Hua Liu, Hua Qiang Yang · 2019 · Cancer Chemotherapy and Pharmacology
Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production
Kevin P. Kotredes, Roshanak Razmpour, Evan M. Lutton, Mercedes Alfonso‐Prieto, Servio H. Ramirez, Ana M. Gamero · 2019 · Oncotarget
Inflammation, Advancing Age and Nutrition
2014 · Elsevier eBooks
Insights into Metabolic Reprogramming in Tumor Evolution and Therapy
Ching‐Feng Chiu, Jonathan Jaime G. Guerrero, Ric Ryan H. Regalado, Jiayan Zhou, Kin Israel Notarte, Yuwei Lu, Paolo C. Encarnacion, Cidne Carles, Edrian M. Octavo, Dan Christopher I. Limbaroc et al. · 2024 · Cancers
Isocitrate dehydrogenase mutations in chondrosarcoma
Georges Azzi, Michel Velez, Maria Cecília Mathias-Machado · 2014 · Current Opinion in Oncology
Untangling the Metabolic Reprogramming in Brain Cancer: Discovering Key Molecular Players Using Mass Spectrometry
Anatoly Sorokin, Vsevolod A. Shurkhay, Пеков Станислав Игоревич, Evgeny S. Zhvansky, Daniil G. Ivanov, Eugene E. Kulikov, Igor A. Popov, Potapov Aa, Е. Н. Николаев · 2019 · Current Topics in Medicinal Chemistry
Targeting Cancer Metabolism and Current Anti-Cancer Drugs
Witchuda Sukjoi, Jarunya Ngamkham, Paul V. Attwood, Sarawut Jitrapakdee · 2021 · Advances in experimental medicine and biology
Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies
Giulia Ambrosini, Marco Cordani, Ali Zarrabi, Sergio Alcón-Rodríguez, Rosa María Sainz, Guillermo Velasco, Pedro González‐Menéndez, Ilaria Dando · 2024 · Cell Communication and Signaling
Revisiting reactive oxygen species production in hypoxia
Ricardo Alva, Jacob E. Wiebe, Jeffrey Alan Stuart · 2024 · Pflügers Archiv - European Journal of Physiology
The role of mutation of metabolism-related genes in genomic hypermethylation
Joshua J. Waterfall, J. Keith Killian, Paul S. Meltzer · 2014 · Biochemical and Biophysical Research Communications
IDHmutations: new genetic signatures in cholangiocarcinoma and therapeutic implications
Darrell R. Borger, Andrew Xiuxuan Zhu · 2012 · Expert Review of Anticancer Therapy
Structural Investigations of the Nickel-Induced Inhibition of Truncated Constructs of the JMJD2 Family of Histone Demethylases Using X-ray Absorption Spectroscopy
Nitai Charan Giri, Lisa Passantino, Hong Sun, Maria Antonietta Zoroddu, Max Costa, Michael J. Maroney · 2013 · Biochemistry
Expanding the Reach of Cancer Metabolomics
Christian M. Metallo · 2012 · Cancer Prevention Research
Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis
Jens Langstein, Michael D. Milsom, Daniel B. Lipka · 2017 · Seminars in Cancer Biology
Inhibitors of both the N -methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases
Joanna Bonnici, Anthony Tumber, Akane Kawamura, Christopher John Schofield · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
Lactate dehydrogenase C is required for the protein expression of a sperm-specific isoform of lactate dehydrogenase A
Mina Dodo, Hiroshi Kitamura, Hiroki Shima, Daisuke Saigusa, Sisca Meida Wati, Nao Ota, Fumiki Katsuoka, Hatsune Chiba, Hiroaki Okae, Takahiro Arima et al. · 2018 · The Journal of Biochemistry
Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression
Jung Eun Park, Shun Wilford Tse, Xue Guo, Christina Assisi, Aida Serra, Gallart Palau Xavier Ramon, Jee Keem Low, Oi Lian Kon, Chor Yong Tay, James P. Tam et al. · 2019 · Oncotarget
The Nuclear-Mitochondrial Crosstalk in Aging: From Mechanisms to Therapeutics.
Yi-Fei Feng, Yan Lu · 2025 · Free Radical Biology & Medicine
Pharmacological characterization of TQ 05310, a potent inhibitor of isocitrate dehydrogenase 2 R140Q and R172K mutants
Mingzhao Gao, Hongmei Zhu, Fu Li, Yun Li, Xubin Bao, Haoyu Fu, Haitian Quan, Lei Wang, Liguang Lou · 2019 · Cancer Science
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme
Jan Korbecki, Klaudyna Kojder, Dariusz Jeżewski, Donata Simińska, Maciej Tarnowski, Patrycja Kopytko, Krzysztof Safranow, Izabela Gutowska, Marta Goschorska, Agnieszka Kolasa et al. · 2020 · Biomolecules
Metabolic Reprogramming and Potential Therapeutic Targets in Lymphoma
Yuyang Pang, Tingxun Lu, Zijun Yidan Xu-Monette, Ken H. Young · 2023 · International Journal of Molecular Sciences
Basic Mechanisms of Immunometabolites in Shaping the Immune Response
Dylan G. Ryan, Christian G. Peace, Alexander Hooftman · 2023 · Journal of Innate Immunity
The broad spectrum 2-oxoglutarate oxygenase inhibitor N-oxalylglycine is present in rhubarb and spinach leaves
Khalid Al‐Qahtani, Bushra Jabeen, Rok Sekirnik, Naheed Riaz, Timothy D. W. Claridge, Christopher John Schofield, James McCullagh · 2015 · Phytochemistry
Dietary fat overcomes the protective activity of thrombospondin-1 signaling in the ApcMin/+ model of colon cancer
David R. Soto‐Pantoja, John M. Sipes, Gema Martin‐Manso, Brian M. Westwood, Niccole Morris, Arunima Ghosh, Nancy J. Emenaker, David D. Roberts · 2016 · Oncogenesis
Promising Molecular Targets for the Targeted Therapy of Biliary Tract Cancers: An Overview
Wenwei Yang, Yongkun Sun · 2021 · OncoTargets and Therapy
Metabolic sensors and their interplay with cell signalling and transcription
Alena Krejčı́ · 2012 · Biochemical Society Transactions
Epigenetic Mechanisms in Leukemias and Lymphomas
Cihangir Duy, Wendy Béguelin, Ari M. Melnick · 2020 · Cold Spring Harbor Perspectives in Medicine
Specific regulation of epigenome landscape by metabolic enzymes and metabolites
Xilan Yu, Shanshan Li · 2024 · Biological reviews/Biological reviews of the Cambridge Philosophical Society
A double surrogate approach for the quantitation of 2-Hydroxyglutarate – An oncometabolite in human brain tumors via LC-MS/MS
Feng Qin Yin, Jennifer Keller, Dennis H. Kraus, Heidi Mangus, Fumin Li, Guowen Liu · 2019 · Journal of Pharmaceutical and Biomedical Analysis
Epigenetic regulation of cancer stem cell and tumorigenesis
Kezhou Zhu, Victoria K. Xie, Suyun Huang · 2020 · Advances in cancer research
Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation
Sehyun Oh, Youngup Cho, Minsun Chang, Sunghyouk Park, Hyuk Nam Kwon · 2021 · Metabolites
Prognostic impact of IDH mutations in chondrosarcoma
Makoto Nakagawa, Masaya Sekimizu, Makoto Endo, Eisuke Kobayashi, Shintaro Iwata, Suguru Fukushima, Akihiko Yoshida, Issay Kitabayashi, Hitoshi Ichikawa, Akira Kawai et al. · 2021 · Journal of Orthopaedic Science
Morin inhibits the transformation of fibroblasts towards myofibroblasts through regulating “PPAR-γ-glutaminolysis-DEPTOR” pathway in pulmonary fibrosis
Yumeng Miao, Yanzhi Geng, Ling Yang, Yun Zheng, Yue Dai, Zhifeng Wei · 2021 · The Journal of Nutritional Biochemistry
IDH1/2 Mutations in Cancer Stem Cells and Their Implications for Differentiation Therapy
Remco Jurriaan Molenaar, Johanna W. Wilmink · 2021 · Journal of Histochemistry & Cytochemistry
Effects of metabolic cancer therapy on tumor microenvironment
Petra Hyroššová, Mirko Milošević, Josef Škoda, Jiří Vachtenheim Jr, Jakub Rohlena, Kateřina Rohlenová · 2022 · Frontiers in Oncology
The role of lysine-specific demethylase 6A (KDM6A) in tumorigenesis and its therapeutic potentials in cancer therapy
Lijuan Chen, Xin-Yang Xu, Xiao-Dan Zhong, Yanjun Liu, Ming-Hui Zhu, Fan Tao, Chang-Yun Li, Qiu Sheng She, Guan-Jun Yang, Jiong Chen · 2023 · Bioorganic Chemistry
Complex role of HIF in cancer: the known, the unknown, and the unexpected
Eric L. Huang, Patricia D.B. Tiburcio, Hyunsung Choi · 2014 · Hypoxia
Mitochondrial metabolic remodeling in response to genetic and environmental perturbations
Kate E.R. Hollinshead, Daniel A. Tennant · 2016 · WIREs Systems Biology and Medicine
Perspectives of immunotherapy in isocitrate dehydrogenase-mutant gliomas
Mirco Friedrich, Lukas Bunse, Wolfgang Wick, Michael Platten · 2018 · Current Opinion in Oncology
Chromatin Architecture as an Essential Determinant of Dendritic Cell Function
Giselle M. Boukhaled, Mario Corrado, Hannah Guak, Connie M. Krawczyk · 2019 · Frontiers in Immunology
Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma
Sanne Venneker, Károly Szuhai, Pancras C.W. Hogendoorn, Judith V.M.G. Bovée · 2019 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis
Shengtao Zhou, Rui R Liu, Kefei Yuan, Tao Yi, Xia Zhao, Canhua Huang, Yuquan Wei · 2012 · Mass Spectrometry Reviews
Quantitative Analysis of Histone Demethylase Probes Using Fluorescence Polarization
Wenqing Xu, Jessica D. Podoll, Xuan Dong, Anthony Tumber, Udo C. T. Oppermann, Xiang Wang · 2013 · Journal of Medicinal Chemistry
Dysregulation of 2-oxoglutarate-dependent dioxygenases by hyperglycaemia: does this link diabetes and vascular disease?
Hannah L.H. Green, Alison C. Brewer · 2020 · Clinical Epigenetics
Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant
Ryan A. Herold, Raphael Reinbold, Clare F. Megarity, Martine I. Abboud, Christopher John Schofield, Fraser Andrew Armstrong · 2021 · The Journal of Physical Chemistry Letters
Metabostemness in cancer: Linking metaboloepigenetics and mitophagy in remodeling cancer stem cells
Prajna Paramita Naik, Swagatika Panigrahi, Ratnakar Parida, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Shankargouda Patil, NML Manjunath, Dipanjan Ghosh, Samir Kumar Patra, Sujit K. Bhutia · 2021 · Stem Cell Reviews and Reports
Mitochondrial Alterations in Prostate Cancer: Roles in Pathobiology and Racial Disparities
Kunwar Somesh Vikramdeo, Amod Sharma, Shashi Anand, Sarabjeet Kour Sudan, Seema Singh, Ajay P. Singh, Santanu Dasgupta · 2023 · International Journal of Molecular Sciences
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies
Hsiao P. J. Voon, Linda L. Hii, Andrew Garvie, Maheshi Udugama, Brian Krug, Caterina Russo, Anderly C. Chüeh, Roger J. Daly, Alison E. Morey, Toby D. M. Bell et al. · 2023 · Genome biology
A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis genome wide
Prodromos Chatzikyriakou, Dimitria Brempou, Mark Quinn, Lauren Michelle Fishbein, Roberta Noberini, Ioannis N. Anastopoulos, Nicola Tufton, Eugénie S. Lim, Rupert Obholzer, Johnathan Hubbard et al. · 2023 · Clinical Epigenetics
State of the Art in Low-Grade Glioma Management: Insights From Isocitrate Dehydrogenase and Beyond
Lauren R. Schaff, Maria Ioannou, Marjolein Geurts, Martin J. van den Bent, Ingo K. Mellinghoff, Karisa C. Schreck · 2024 · American Society of Clinical Oncology Educational Book
Configuration of a High-Content Imaging Platform for Hit Identification and Pharmacological Assessment of JMJD3 Demethylase Enzyme Inhibitors
Alpa Mulji, Carl P. Haslam, Fiona Brown, Rebecca A. Randle, Bhumika Karamshi, Julia E. Smith, Robert Eagle, J. A. Muñoz, Joanna Taylor, Arshad Sheikh et al. · 2012 · SLAS DISCOVERY
Comprehensive molecular tumor profiling in radiation oncology: How it could be used for precision medicine
Iris Eke, Adeola Y. Makinde, Molykutty J. Aryankalayil, Mansoor M. Ahmed, C. Norman Coleman · 2016 · Cancer Letters
In-silico gene essentiality analysis of polyamine biosynthesis reveals APRT as a potential target in cancer
Jon Pey, Edurne San José‐Eneriz, María Carmen Ochoa, Iñigo Apaolaza, Pedro de Atauri, Ángel Rubio, Xabier Cendoya, Estíbaliz Miranda, Leire Gárate, Marta Cascante et al. · 2017 · Scientific Reports