The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte
Open accessAbstract
Berberine (BBR), an isoquinoline alkaloid, has a wide range of pharmacological effects, yet its exact mechanism is unknown. In order to understand the anti-adipogenic effect of BBR, we studied the change of expression of several adipogenic enzymes of 3T3-L1 cells by BBR treatment. First, we measured the change of leptin and glycerol in the medium of 3T3-L1 cells treated with 1 micrometer, 5 micrometer and 10 micrometer concentrations of BBR. We also measured the changes of adipogenic and lipolytic factors of 3T3-L1. In 3T3-L1 cells, both leptin and adipogenic factors (SREBP-1c, C/EBP-alpha, PPAR-gamma, fatty acid synthase, acetyl-CoA carboxylase, acyl-CoA synthase and lipoprotein lipase) were reduced by BBR treatment. Glycerol secretion was increased, whereas expression of lipolytic enzymes (hormone-sensitive lipase and perilipin) mRNA was slightly decreased. Next, we measured the change of inflammation markers of 3T3-L1 cells by BBR treatment. This resulted in the down-regulation of mRNA level of inflammation markers such as TNF-alpha, IL-6, C- reactive protein and haptoglobin. Taken together, our data shows that BBR has both anti-adipogenic and anti-inflammatory effects on 3T3-L1 adipocytes, and the anti-adipogenic effect seems to be due to the down-regulation of adipogenic enzymes and transcription factors.
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Kong, W., Wei, J., Abidi, P., Lin, M., Inaba, S., Li, C., Wang, Y., Wang, Z., Si, S., Pan, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1135 · Cited by 1,391
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Jeong, H. W., Hsu, K. C., Lee, J.-W., Ham, M., Huh, J. Y., Shin, H. J., Kim, W. S., & Kim, J. B. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90599.2008 · Cited by 454
Antioxidant and Anti‐Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
Li, Z., Geng, Y.-N., Jiang, J.-D., & Kong, W.-J. (2014) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2014/289264 · Cited by 383
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Sen, T., & Samanta, S. K. (2014) · Advances in Biochemical Engineering/Biotechnology · doi:10.1007/10_2014_273 · Cited by 330
Pirillo, A., & Catapano, A. L. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.032 · Cited by 305
Berberine and Its Role in Chronic Disease
Cicero, A. F. G., & Baggioni, A. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-41334-1_2 · Cited by 285
Metadata
- Authors
- Choi, B.-H., Ahn, I.-S., Kim, Y.-H., Park, J.-W., Lee, S.-Y., Hyun, C.-K., & Do, M.-S.
- Venue
- Experimental & Molecular Medicine
- Published
- 2006-12-01
- Volume
- 38
- Issue
- 6
- Pages
- 599-605
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- OpenAlex
- W2040735329
- Cited by
- 166
- References
- 1
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- gold
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