The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Antioxidant and Anti‐Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus
Open accessAbstract
Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities. Recent studies showed that BBR had antioxidant and anti‐inflammatory activities, which contributed in part to its efficacy against diabetes mellitus. In this review, we summarized the antioxidant and anti‐inflammatory activities of BBR as well as their molecular basis. The antioxidant and anti‐inflammatory activities of BBR were noted with changes in oxidative stress markers, antioxidant enzymes, and proinflammatory cytokines after BBR administration in diabetic animals. BBR inhibited oxidative stress and inflammation in a variety of tissues including liver, adipose tissue, kidney and pancreas. Mechanisms of the antioxidant and anti‐inflammatory activities of BBR were complex, which involved multiple cellular kinases and signaling pathways, such as AMP‐activated protein kinase (AMPK), mitogen‐activated protein kinases (MAPKs), nuclear factor erythroid‐2‐related factor‐2 (Nrf2) pathway, and nuclear factor‐κ B (NF‐κ B) pathway. Detailed mechanisms and pathways for the antioxidant and anti‐inflammatory activities of BBR still need further investigation. Clarification of these issues could help to understand the pharmacology of BBR in the treatment of diabetes mellitus and promote the development of antidiabetic natural products.
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Cited by
Berberine in Cardiovascular and Metabolic Diseases: From Mechanisms to Therapeutics
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Natural Products for the Treatment of Type 2 Diabetes Mellitus
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Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
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Metadata
- Authors
- Li, Z., Geng, Y.-N., Jiang, J.-D., & Kong, W.-J.
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2014-01
- Volume
- 2014
- Issue
- 1
- Pages
- 289264-289264
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- OpenAlex
- W2030686490
- Cited by
- 383
- References
- 130
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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