Cited by 379Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and PathologyIon Channels and Receptors

The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Open access

Ly, Luong Dai, Xu, Shanhua, Choi, Seong-Kyung, Ha, Chae-Myeong, Thoudam, Themis, Cha, Seung-Kuy, Wiederkehr, Andreas, Wollheim, Claes B, Lee, In-Kyu, Park, Kyu-Sang·2017·Experimental & Molecular Medicine

DOI 10.1038/emm.2016.157PMC PMC5336562

Open this paper in CoChat — free account Open PDF

Abstract

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases. CD36 is a major mediator of cellular FFA uptake. Inside the cell, saturated FFAs are able to induce the production of cytosolic and mitochondrial reactive oxygen species (ROS), which can be prevented by co-exposure to unsaturated FFAs. There are close connections between oxidative stress and organellar Ca2+ homeostasis. Highly oxidative conditions induced by palmitate trigger aberrant endoplasmic reticulum (ER) Ca2+ release and thereby deplete ER Ca2+ stores. The resulting ER Ca2+ deficiency impairs chaperones of the protein folding machinery, leading to the accumulation of misfolded proteins. This ER stress may further aggravate oxidative stress by augmenting ER ROS production. Secondary to ER Ca2+ release, cytosolic and mitochondrial matrix Ca2+ concentrations can also be altered. In addition, plasmalemmal ion channels operated by ER Ca2+ depletion mediate persistent Ca2+ influx, further impairing cytosolic and mitochondrial Ca2+ homeostasis. Mitochondrial Ca2+ overload causes superoxide production and functional impairment, culminating in apoptosis. This vicious cycle of lipotoxicity occurs in multiple tissues, resulting in β-cell failure and insulin resistance in target tissues, and further aggravates diabetic complications. High levels of the fatty acid palmitate cause cell death and exacerbate the complications of type 2 diabetes. Kyu-Sang Park at Yonsei University Wonju College of Medicine and colleagues review the molecular mechanisms responsible for palmitate-induced toxicity. The transmembrane protein CD36 mediates the uptake of palmitate into cells where it triggers the production of reactive oxygen species (ROS). Overproduction of ROS interferes with the cell's protein-processing organelle, the endoplasmic reticulum (ER), leading to damaged misfolded proteins and to ER calcium loss. This loss further damages protein folding and increases ROS production. Moreover, it causes an influx of calcium into mitochondria, the cell's power plants, and ultimately results in cell death. Therapeutic agents that inhibit CD36, reduce ROS production or prevent ER calcium loss could break this toxic cycle and contribute to the treatment of type 2 diabetes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/emm.2016.157

Cites

161 of 161 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
Bootman, M. D., Missiaen, L., Parys, J. B., SMEDT, H. D., & Casteels, R. (1995) · Biochemical Journal · doi:10.1042/bj3060445 · Cited by 5,131
Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis
Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 5,008
Mitochondrial control of cell death
Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103
THE MAMMALIAN UNFOLDED PROTEIN RESPONSE
Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,099
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075
Mitochondria as sensors and regulators of calcium signalling
Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781
Redox regulation of cell survival
Trachootham, D., Lu, W., Ogasawara, M. A., Valle, N. R.-D., & Huang, P. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1957 · Cited by 1,781

Flagged first, then by citations

Show all 161 references

Sorted by citations

Items 301–379 of 379

Increased glycolysis is an early outcome of palmitate-mediated lipotoxicityPreprint
Kakimoto, P. A., Zorzano, A., & Kowaltowski, A. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.10.144808 · Cited by 2
Palmitic Acid-induced Renal Injury: Unravelling the Molecular Mechanisms and the Protective Role of Lycopene
James, A. S., Ugwor, E. I., Akamo, A. J., Akinloye, D. I., Kosoko, A. M., Olagunju, B. A., Ezenandu, E. O., Amaogu, C. C., Adebiyi, V. A., Thomas, F. C., et al. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01775-6 · Cited by 1
Recommended Indications: Carbon Monoxide Poisoning
Ahmed, A. U., Bhattacharya, C., & Agrawal, S. (2025) · Springer eBooks · doi:10.1007/978-3-032-06346-5_9 · Cited by 1
Preconditioning and supplementation with glutathione ameliorates oxidative stress, mitochondrial dysfunction, and restores metabolic imbalance in insulin-resistant myotubes
Save, S. N., Parveen, N., Sonis, G., Chavan, S., Chugh, J., & Sharma, S. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153997 · Cited by 1
GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction
Yao, L., Liang, X., Li, B., Chen, B., Wang, X., Hong, M., Feng, Q., Qiao, Y., Liu, Z., Wang, K. L., et al. (2026) · Interdisciplinary medicine · doi:10.1002/inmd.70148 · Cited by 1
The roles of protein palmitoylation during viral infection
Li, Y., & Zheng, C. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0083 · Cited by 1
Epicardial Adipose Tissue and Cardiac Arrhythmias
Канорский, С. Г. (2022) · Cardiac Arrhythmias · doi:10.17816/cardar107112 · Cited by 1
Effects of cellular lipids on heart in pathology and physiology
Balatskyi, V. V., Wołosiewicz, M., Dobosz, A. M., Tracz‐Gaszewska, Z., Sówka, A., Kendziorek, M., Krogulec, E., Navrulin, V. O., & Dobrzyń, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95582-9.00003-6 · Cited by 1
The association between serum free fatty acid levels and neurological outcomes in out-of-hospital cardiac arrest patients: A prospective observational study
Lee, D. H., Lee, B. K., Jeung, K., & Jung, Y.-H. (2024) · Medicine · doi:10.1097/md.0000000000038772 · Cited by 1
Small Molecule Inhibitors of Arylamine N-Acetyltransferase 1 Attenuate Cellular Respiration
Choudhury, C., Egleton, J. E., Butcher, N. J., Russell, A. J., & Minchin, R. F. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00282 · Cited by 2
Sinalização de cálcio e espécies reativas de oxigênio em doenças hepáticas
Nascimento, C. A. L., Lima, R. T., de Sousa, R. L., da Silva, P. B., Farias, Y. D. C., Silva, H. F. M. D., Amaomo, M. L., dos Santos, T. F. C., Melo, M. L., & Filho, A. C. M. L. (2024) · Revista Eletrônica Acervo Saúde · doi:10.25248/reas.e17234.2024 · Cited by 1
RNA binding protein HuD regulates fatty acid oxidation in pancreatic β-cells by modulating long-chain acyl-CoA dehydrogenase expression
Seo, J., Ryu, S., Zhang, W., Lee, E. K., & Jeong, S. M. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2542168 · Cited by 2
Behavioral and transcriptomic analyses reveal neurotoxicity and mechanism of action of DEHP in female pubertal mice with or without type 2 diabetes mellitus
Feng, W., Chu, Y., Ji, X., Mao, G., Zhao, T., Chen, Y., Okeke, E. S., Ai, L., Yang, L., & Wu, X. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103337 · Cited by 1
Myocardial Oxidative Stress and Metabolic Diseases
El‐Sayyad, H. I. (2019) · Springer eBooks · doi:10.1007/978-981-13-8946-7_4 · Cited by 1
Friend or Foe
Annis, S., Safdar, A., Biala, E., Saleem, A., Li, H., Gandhi, P., Fleischmann, Z., Castaneda‐Sceppa, C., Tilly, J. L., Woods, D. C., et al. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch31 · Cited by 1
A novel fibroblast growth factor 1 variant reverses nonalcoholic fatty liver disease in type 2 diabetes.
Lin, Q. (2018) · doi:10.18297/etd/3016
Oxidative Stress and Calcium Dyshomeostasis Mediated CPF-Induces EPC Cell Apoptosis and NecroptosisPreprint
Miao, Z., Cui, J., Yu, M., & Teng, X. (2021) · Research Square · doi:10.21203/rs.3.rs-886171/v1 · Cited by 1
SUMOylation of ERp44 Enhances Ero1α ER Retention Contributing to the Pathogenesis of Obesity and Insulin ResistancePreprint
Xie, H., Wang, Y., Liu, X., Gao, J. L., Yang, C., Huang, T., Zhang, L., Luo, X., Gao, Z., Wang, T., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4129424 · Cited by 1
Activation of Sarco/Endoplasmic Reticulum Ca2+-ATPase by Natural Polyphenolic Compounds. Mechanism of Protection against Oxidative StressPreprint
Heger, V., Barbora, B., Májeková, M., Rezbáriková, P., Girst, G., Ahmed, S. H. H., Gonda, T., Hunyadi, A., & Horáková, Ľ. (2023) · Preprints.org · doi:10.20944/preprints202308.0834.v1 · Cited by 1
Effects of the Saturated Fatty Acid Palmitate on Neuroinflammation, ER Stress, and Pomc mRNA Expression in Hypothalamic mHypoA-POMC/GFP Neurons
Tse, E. K. (2017) · TSpace (University of Toronto)
In vitro assessment of aspalathin-enriched Rooibos (Aspalathus linearis) extract treatment in statin-induced hepatotoxicity
Millar, D. A. (2019) · SUNScholar (Stellenbosch University)
Interplay between dietary sugars and fats and insulin resistance
Ramlagan, P., Bahorun, T., & Neergheen, V. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816918-6.00022-6
Development of avocado derived polyhydroxylated fatty alcohols as metabolic modulators
Ahmed, N. (2019) · The Atrium (University of Guelph)
The impact on high-fat diet on skeletal muscle stem cell recruitment in CD36 deficient mice
Verpoorten, S. (2019) · Repository@Hull (Worktribe) (University of Hull)
Membrane Fluidity Regulation: From C. elegans to mammalian cells
Devkota, R. (2020) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Cytoprotective effects of combination of gypenosides and Costus pictus D.Don extract in BRIN-BD11 β-cellsPreprint
Patibandla, C., Campbell, M. J., Bennett, L. A., Shu, X., & Patterson, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.07.286435
The Role of Obesity-Induced Inflammation in Pancreatic -Cell Dysfunction and Death
Melloul, D. (2020) · Interventions in Obesity & Diabetes · doi:10.31031/iod.2020.03.000573
Astragalosides IV Improves Palmitic Acid-induced Renal Tubular Epithelial Cells Injury Due to Inhibition of NLRP3 InflammasomePreprint
Zhang, Y., Li, Y., Su, Y., Zhu, Y., Han, Y., Dong, X., Li, W., & Li, W. (2020) · Research Square · doi:10.21203/rs.3.rs-122884/v1
Impact of Bariatric Surgery on Circulating Inflammatory and Pro-vascular Progenitor Cell Populations
Trac, J. Z. (2020) · TSpace (University of Toronto)
CD36 regulates β cell differentiation and influences type 2 diabetic sepsisPreprint
Liu, H., Gu, L., Shi, Y., Shu, H., Huang, F., Wan, X. H., Liu, Y., & Lei, Z. (2021) · Research Square · doi:10.21203/rs.3.rs-851347/v1
De betekenis van angst bij patiënten met een hooggradig glioom in de palliatieve fase. Een eerste verkenning.
de Bruin, M. P. J. (2011) · Utrecht University Repository (Utrecht University)
Papel da via de sinalização Wnt canônica na proliferação e função secretora da célula beta pancreática em condições in vitro e na pré-diabetes
Maschio, D. A. (2018) · doi:10.47749/t/unicamp.2018.1102624
Pathogenesis
Walker, M., Yu, X., & Gastaldelli, A. (2022) · doi:10.1093/med/9780198870197.003.0248
Metabolic and Metabo-Clinical Signatures of T2D, Obesity, Retinopathy and Dyslipidemia.
Yousri, N. A., Suhre, K., Yassin, E., Al-Shakaki, A., Robay, A., Chidiac, O. M., Hunt, S. C., Crystal, R. G., & Fakhro, K. A. (2021) · doi:10.2337/figshare.16896382 · Cited by 1
Metabolic and Metabo-Clinical Signatures of T2D, Obesity, Retinopathy and Dyslipidemia.
Yousri, N. A., Suhre, K., Yassin, E., Al-Shakaki, A., Robay, A., Chidiac, O. M., Hunt, S. C., Crystal, R. G., & Fakhro, K. A. (2021) · doi:10.2337/figshare.16896382.v1
Faculty Opinions recommendation of Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress.
ECELBARGER, C. A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732790761.793546067
Spatially Resolved Metabolites in Stable and Vulnerable Human Atherosclerotic Plaques Identified by Mass Spectrometry ImagingPreprint
Seeley, E. H., Liu, Z., Yuan, S. S., Stroope, C., Cockerham, E. D., Rashdan, N. A., Finney, A. C., Kumar, D., Das, S. R., Razani, B., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.30.494038
Papel da NADPH oxidase durante a insulite e a lipotoxicidade: estresse oxidativo, disfunção e morte de células beta pancreáticas.
Vilas‐Boas, E. A. (2020) · doi:10.11606/t.42.2020.tde-03012022-095722
Effect of Uncaria tomentosa aqueous extract on the response to palmitate- induced lipotoxicity in cultured skeletal muscle cellsPreprint
Freitas, B. L., dos Santos, J. F., Reigado, G. R., Fernandes, M. T. P., Chambergo, F. S., Carvalho, C. R. D. O., & Nunes, V. A. (2023) · Research Square · doi:10.21203/rs.3.rs-2861354/v1
Bioenergetic and redox signaling in hepatic steatosis models: Integrative analysis of nutritional, hormonal, and inflammatory stimuli
Kakimoto, P. A. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.46.2021.tde-10082023-115406
The Role of Parkin in Rat Pancreatic Beta Cells Fate
Verdi, H., Çebi, H. P. B., Yalçın, Y., Özkan, T., Ok, M. A., Sunguroğlu, A., & Ataç, F. B. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.8.9 · Cited by 1
The analysis of coffee-green tea-turmeric combination against cardiac-metabolic syndrome using metabolite profiling, gene expression, and in silico approach
Rachmawati, E., Rohman, M. S., Widodo, N., Lukitasari, M., Nugroho, D. A., Hermanto, F. E., & Kholis, M. N. (2023) · Journal of Pharmacy & Pharmacognosy Research · doi:10.56499/jppres23.1702_11.6.961
Exploring the Therapeutic Mechanism of Jiangtang Sanhao Formula in Alleviating Insulin Resistance in Skeletal Muscle Cells: Involvement of AMPK/SIRT1/PGC-1α pathway？Preprint
Ye, Z., Zhao, Y. D., Fang, X., Xu, B., Shi, H., Li, R., Mo, F., Zhang, D., Zhao, D., & Gao, S. (2023) · Research Square · doi:10.21203/rs.3.rs-3445076/v1
Tepung Tapioka, Kentang, dan Jagung sebagai Purifikasi Minyak Goreng Bekas (Kajian Kadar Malondealdehid, Asam Lemak Bebas, dan Tingkat Kekeruhan)
Susilo, J., Purnama, S. J., & Suyudi, S. D. (2023) · Indonesian Journal of Pharmacy and Natural Product · doi:10.35473/ijpnp.v6i02.2294
Isoliquiritigenin induced endoplasmic reticulum stress in zebrafish embryosPreprint
Hu, D., Xia, Y., Zhang, C., Fan, S., Lin, L., Luo, P., Xiong, Y., & Su, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4229145/v1
Effects of Selected Dietary Micronutrients on Pathogenesis of Metabolic Syndrome: Molecular Mechanisms Involved and Therapeutic PotentialPreprint
Oyalo, J. O., Aduol, K. O., & Ndiege, M. A. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4840333
SRXRF analysis of serum of type 2 Diabetes Mellitus patients with controlled blood glucose levels
Rao, N. S., Sarita, P., & Raju, G. J. N. (2024) · AIP conference proceedings · doi:10.1063/5.0216257
ERAD deficiency disrupts mitochondrial bioenergetics by altering MAM Ca2+ in human hepatic cellsPreprint
Hu, Y., Bai, Y., Jiang, B., Wang, M., & Zhang, F. (2024) · Research Square · doi:10.21203/rs.3.rs-4939621/v1
AMPK activation attenuates high glucose-induced oxidative stress and apoptosis through regulation of TRPM2-mediated signaling pathway in endothelial cellsPreprint
Lu, T., Zhang, Y., Zhou, D., Wang, Z., Zhao, L., & Xu, Q. (2024) · Research Square · doi:10.21203/rs.3.rs-5312586/v1
Hepatic ADMA–PRMT1 axis regulation is associated with NO-dependent endothelial dysfunction in MASHPreprint
Lallement, J., Bott, S., Esfahani, H., Serafimov, K., Henderson, M., Benoit, Z., Dumas, L., Al‐Siyabi, S., Féron, O., Leclercq, I. A., et al. (2025) · SSRN Electronic Journal · doi:10.1101/2025.06.10.658894
Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role of de novo lipogenesis and treatment perspectives
Khan, M. M., Khan, Z. A., Khan, M. A., & Pandey, G. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i7.106194
Association Between Blood Free Fatty Acid Concentrations in Midlife and Cerebral Small Vessel Disease
Nukata, R., Hattori, Y., Noda, K., Yoshimoto, T., & Ihara, M. (2025) · Antioxidants · doi:10.3390/antiox14091107
Targeting insulin signaling and TRAF2/JNK pathway: a comprehensive in silico study of Uncaria tomentosa compoundsPreprint
Freitas, B. L., Parate, S., Jha, V., Chambergo, F. S., Eriksson, L. A., & Nunes, V. A. (2025) · Research Square · doi:10.21203/rs.3.rs-7962616/v1
Transcriptional profiles reveal deregulation of lipid metabolism and inflammatory pathways in neurons exposed to palmitic acidPreprint
Leon, M. F., Millman, N. A., Pérez‐Domínguez, M., Arciga, K. M. T., Vega, R. R., Velazquez, I. A. D. L. R., Canon, C. A., Herrera, L. A., Arias, C., & Barrios, R. G. (2021) · Research Square · doi:10.21203/rs.3.rs-319265/v1
Additional file 1 of Effect of Uncaria tomentosa aqueous extract on the response to palmitate-induced lipotoxicity in cultured skeletal muscle cells
Freitas, B. L., dos Santos, J. F., Reigado, G. R., Fernandes, M. T. P., Alcalde, F. S. C., Carvalho, C. R. D. O., & Nunes, V. A. (2024) · Figshare · doi:10.6084/m9.figshare.26640349
Additional file 3 of Dihydromyricetin attenuates palmitic acid-induced oxidative stress by promoting autophagy via SIRT3-ATG4B signaling in hepatocytes
Huang, L., Zeng, X., Li, B., Wang, C., Zhou, M., Lang, H., Yi, L., & Mi, M. (2021) · Figshare · doi:10.6084/m9.figshare.16599557
Additional file 2 of Dihydromyricetin attenuates palmitic acid-induced oxidative stress by promoting autophagy via SIRT3-ATG4B signaling in hepatocytes
Huang, L., Zeng, X., Li, B., Wang, C., Zhou, M., Lang, H., Yi, L., & Mi, M. (2021) · Figshare · doi:10.6084/m9.figshare.16599554
Additional file 1 of Dihydromyricetin attenuates palmitic acid-induced oxidative stress by promoting autophagy via SIRT3-ATG4B signaling in hepatocytes
Huang, L., Zeng, X., Li, B., Wang, C., Zhou, M., Lang, H., Yi, L., & Mi, M. (2021) · Figshare · doi:10.6084/m9.figshare.16599551
Elementary status of patients with type 2 diabetes depending on the duration of the disease, age and sex
Кравченко, В., Sokolova, L. K., Ivaskiv, K. Y., Rakov, О. V., Kulchynska, Y. B., & Tronko, M. D. (2025) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.21.8.2025.1649
Effect of Vitamin D on Human Asymmetric Dimethylarginine in a Pediatric Population: A Connection between Vitamin D, Oxidative Stress, and Inflammation
Suyal, M., Khan, A. M. A., Nabi, N., Sultana, F., Gupta, P., Ansari, M. A., Gautam, R., Kapur, P., Kohli, S., & Chandra, K. (2026) · The Journal of Medical Sciences · doi:10.5005/jp-journals-10045-00436
Glibenclamide attenuates neuronal pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice
Chen, C.-L., Chang, L.-C., Chen, C.-Y., Lai, Y.-S., Chen, P., & Lin, C.-H. (2026) · Biomedical Journal · doi:10.1016/j.bj.2026.100972 · Cited by 1
The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival
Oshry, M., Isaac, R., Boura‐Halfon, S., Casana, E., Sampson, S. R., Lev, S., Bosch, F., Zick, Y., & Vinik, Y. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl44406
Rôles et mécanismes d’action de la protéine Epac1 mitochondriale dans les pathologies cardiaques
Laudette, M. (2019) · theses.fr (ABES) · doi:10.70675/5a24dee4ze02cz4524za612zea3224b1ea32
Un mécanisme commun peut-il sous-tendre l'horloge moléculaire de la microglie et l'activité neuronale dans le contrôle du métabolisme et de la mémoire ?
Wang, X.-L. (2021) · theses.fr (ABES) · doi:10.70675/28f14a3fz0911z4de5z820fz4a0c6883e0fd
Pueraria montana var. lobata Root Extract Alleviates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Increasing Mitochondrial β‐Oxidation and Mitochondrial‐Peroxisome Contact
Lu, H., Lee, D., Huang, Y.-W., Chen, C., Chang, T., Chang, W., Chen, M., Yen, J., & Huang, S. (2026) · Phytotherapy Research · doi:10.1002/ptr.70331
Role of Cell Surface Receptors in Palmitic Acid-Induced Expression of IL-1β in Microglial Cells
Jadeja, V., Ma, S., & Zhou, H. (2026) · Lipidology · doi:10.3390/lipidology3020015
Mitochondrial Dysfunction Contributes to Endothelial Damage in Metabolic Diseases: Role of Mitochondrial DNA in Inflammation
Velasquez-Esparza, M. M., López-Velázquez, R., Cázares-Preciado, A., Miranda-Roblero, H. O., Pérez-Treviño, P., Guerrero-Beltrán, C. E., & Garcı́a, N. (2026) · Handbook of experimental pharmacology · doi:10.1007/164_2026_805
High-Concentration Cyanidin-3-O-Glucoside Attenuates Palmitic Acid-Induced Oxidative Stress via ROS Suppression in Pancreatic β-Cells
Chitwattananont, S., Sawasvirojwong, S., & Muanprasat, C. (2026) · Journal of Experimental Pharmacology · doi:10.2147/jep.s562755
Modulatory Activity of Uncaria tomentosa Extract in the Expression of Proteins Involved in the Unfolded Protein Response and Insulin Resistance
Freitas, B. L., Camandona, V. D. L., Chanavat, A. M., Reigado, G. R., Carvalho, C. R. D. O., Chambergo, F. S., & Nunes, V. A. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060624
PRDX1 Suppression Drives Chromium-Induced Hepatotoxicity via Calcium-Mediated Mitochondrial-ER Dysfunction and Ferroptosis
Han, M., Wu, Z., Guo, S., Chen, B., Wang, J., Yu, J. K., Huang, H., Guo, J., Tang, Z., Huang, H., et al. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c03041
Palmitate-induced oxidative and conformational perturbations of SERCA impair Ca2+-ATPase activity and β-cell function
Rezbáriková, P., Micháliková, S., Heger, V., & Viskupičová, J. (2026) · Cell Calcium · doi:10.1016/j.ceca.2026.103178
Obesity-driven high incidence of ovarian cancer: Molecular insights and therapeutic interventions targeting PI3K/AKT/mTOR, leptin-JAK/STAT, and NF-κB signaling pathways
Azlan, A. H. M., Subramaniyan, V., Ong, L. C., Dawe, G. S., & Ravi, R. N. (2026) · Obesity Medicine · doi:10.1016/j.obmed.2026.100741
Nanoplastic Particle Exposure Induces Toxicity and Amplifies Cellular Stress in THP‐1 Macrophages: Insights on Molecular Pathways and Circulating Proteome Interaction
Mahalakshmi, B., Maadurshni, G. B., Anjana, T. M., & Manivannan, J. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.71103
Effects of bioprocessed potato peel extract on hepatic steatosis in obese rats: modulation of lipid metabolism, bile acid synthesis, and oxidative stress
Sae-jong, S., Sutthiwong, N., Jákó, P., Phoungpetchara, I., Malakul, W., & Tunsophon, S. (2026) · Food Production Processing and Nutrition · doi:10.1186/s43014-026-00420-w
Suppression of ER stress underlies Montelukast's neuroprotective actions in D-gal/AlCl3-induced Alzheimer's disease in rats
Mahmoud, A. H., Ibrahim, S. M., El-Yamany, M. F., Gowifel, A. M. H., & Khattab, M. A. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111220
Obesity-induced mesenchymal stem cell dysfunction: from molecular mechanisms to therapeutic strategies
Elmaraezy, A., Zhu, X.-Y., Eirin, A., & Lerman, L. O. (2026) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2026.85
Hyperparathyroïdie primaire et troubles de la tolérance au glucose : vers une nouvelle indication chirurgicale ?
Scheyer, N. (2026) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2026.09.019
Palmitic acid-induced mitochondrial dysfunction
de Oliveira, M. R. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00015-4
BindingDB Entry 50049322: Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect isletβ-cells from apoptosis.
BindingDB (2019) · UC San Diego · doi:10.7270/q2xw4n3p

Authors: Ly, L. D., Xu, S., Choi, S.-K., Ha, C.-M., Thoudam, T., Cha, S.-K., Wiederkehr, A., Wollheim, C. B., Lee, I.-K., & Park, K.-S.
Affiliations: Yonsei University (KR)
Kyungpook National University Hospital (KR)
University of Geneva (CH)
Corresponding author: Park, Kyu-Sang
ORCID: Choi, Seong-Kyung
Ha, Chae-Myeong
Thoudam, Themis
Cha, Seung-Kuy
Wiederkehr, Andreas
Wollheim, Claes B
Lee, In-Kyu
Park, Kyu-Sang
Venue: Experimental & Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2017-02-03
Volume: 49
Issue: 2
Pages: e291-e291
ISSN: 1226-3613 (ISSN-L)
2092-6413
DOI: 10.1038/emm.2016.157
PMC: PMC5336562
OpenAlex: W2584561009
Cited by: 378
References: 161
Citations by year: 2026: 30 · 2025: 44 · 2024: 36 · 2023: 53 · 2022: 42 · 2021: 60 · 2020: 39 · 2019: 35 · 2018: 32 · 2017: 5
FWCI: 3.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0 (tdm)
creativecommons.org/licenses/by-nc-sa/4.0 (vor)
Locations: Experimental & Molecular Medicine (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders: Korea Health Industry Development Institute (HI16C1501)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: palmitate, lipotoxicity, type 2 diabetes, oxidative stress, calcium homeostasis, CD36, free fatty acids, reactive oxygen species, endoplasmic reticulum calcium depletion, endoplasmic reticulum stress, protein misfolding, mitochondrial calcium overload, apoptosis, beta-cell failure, insulin resistance, unsaturated fatty acids
MeSH terms: Animals, Calcium, Diabetes Mellitus, Type 2, Endoplasmic Reticulum, Fatty Acids, Nonesterified, Humans, Mitochondria, Palmitic Acids, Reactive Oxygen Species, Oxidative Stress, CD36 Antigens, Insulin-Secreting Cells, Endoplasmic Reticulum Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks