Wollheim, Claes B.

Regulation of insulin release by calcium.

Wollheim, C. B., & Sharp, G. W. (1981) · Physiological Reviews

Pancreatic function and diabetesIon channel regulation and function

Cited by 849

Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion

Dayeh, T., Volkov, P., Salö, S., Hall, E., Nilsson, E., Olsson, A. H., Kirkpatrick, C. L., Wollheim, C. B., Eliasson, L., Rönn, T., et al. (2014) · PLoS Genetics

Epigenetics and DNA MethylationPancreatic function and diabetes

Cited by 523

Mitochondrial function in normal and diabetic β-cells

Maechler, P., & Wollheim, C. B. (2001) · Nature

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 519

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly, L. D., Xu, S., Choi, S.-K., Ha, C.-M., Thoudam, T., Cha, S.-K., Wiederkehr, A., Wollheim, C. B., Lee, I.-K., & Park, K.-S. (2017) · Experimental & Molecular Medicine

Endoplasmic Reticulum Stress and DiseaseMitochondrial Function and Pathology

Cited by 378

Loss of Connexin36 Channels Alters β-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release

Ravier, M. A., Güldenagel, M., Charollais, A., Gjinovci, A., Caille, D., Söhl, G., Wollheim, C. B., Willecke, K., Henquin, J.-C., & Meda, P. (2005) · Diabetes

Pancreatic function and diabetesConnexins and lens biology

Cited by 360

Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

Yang, B. T., Dayeh, T. A., Volkov, P. A., Kirkpatrick, C. L., Malmgren, S., Jing, X., Renström, E., Wollheim, C. B., Nitert, M. D., & Ling, C. (2012) · Molecular Endocrinology

Pancreatic function and diabetesEpigenetics and DNA Methylation

Cited by 301

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

Kaufmann, J. E., Oksche, A., Wollheim, C. B., Günther, G., Rosenthal, W., & Vischer, U. M. (2000) · Journal of Clinical Investigation

Platelet Disorders and TreatmentsCardiovascular, Neuropeptides, and Oxidative Stress Research

Cited by 275

Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

Yang, B. T., Dayeh, T. A., Kirkpatrick, C. L., Taneera, J., Kumar, R., Groop, L., Wollheim, C. B., Nitert, M. D., & Ling, C. (2011) · Diabetologia

Pancreatic function and diabetesEpigenetics and DNA Methylation

Cited by 251

Impaired insulin secretion and glucose tolerance in β cell‐selective CaV1.2 Ca2+ channel null mice

Schulla, V., Renström, E., Feil, R., Feil, S., Franklin, I., Gjinovci, A., Jing, X., Laux, D., Lundquist, I., Magnuson, M. A., et al. (2003) · The EMBO Journal

Pancreatic function and diabetesIon channel regulation and function

Cited by 234

VAMP‐2 and cellubrevin are expressed in pancreatic beta‐cells and are essential for Ca(2+)‐but not for GTP gamma S‐induced insulin secretion.

Regazzi, R., Wollheim, C. B., Lang, J., Theler, J. M., Rossetto, O., Montecucco, C., Sadoul, K., Weller, U., Palmer, M., & Thorens, B. (1995) · The EMBO Journal

Pancreatic function and diabetesCellular transport and secretion

Cited by 233

Preserving insulin secretion in diabetes by inhibiting VDAC1 overexpression and surface translocation in β cells

Zhang, E., Mohammed Al-Amily, I., Mohammed, S., Luan, C., Asplund, O., Ahmed, M., Ye, Y., Ben-Hail, D., Soni, A., Vishnu, N., et al. (2019) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 171

Glucose Stimulates Glucagon Release in Single Rat α-Cells by Mechanisms that Mirror the Stimulus-Secretion Coupling in β-Cells

Olsen, H. L., Theander, S., Bokvist, K., Buschard, K., Wollheim, C. B., & Gromada, J. (2005) · Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 156

Mitochondrial signals drive insulin secretion in the pancreatic β-cell

Wiederkehr, A., & Wollheim, C. B. (2012) · Molecular and Cellular Endocrinology

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 133

PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression

Gauthier, B. R., Wiederkehr, A., Baquié, M., Dai, C., Powers, A. C., Kerr-Conte, J., Pattou, F., MacDonald, R. J., Ferrer, J., & Wollheim, C. B. (2009) · Cell Metabolism

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 115

Synaptotagmin V and IX isoforms control Ca2+-dependent insulin exocytosis

Iezzi, M., Kouri, G., Fukuda, M., & Wollheim, C. B. (2004) · Journal of Cell Science

Cellular transport and secretionPancreatic function and diabetes

Cited by 109

Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells.

Pralong, W. F., Hunyady, L., Várnai, P., Wollheim, C. B., & Spät, A. (1992) · Proceedings of the National Academy of Sciences

Hormonal Regulation and HypertensionIon Transport and Channel Regulation

Cited by 104

Expression and localisation of synaptotagmin isoforms in endocrine β-cells: their function in insulin exocytosis

Gut, A., Kiraly, C. E., Fukuda, M., Mikoshiba, K., Wollheim, C. B., & Lang, J. (2001) · Journal of Cell Science

Cellular transport and secretionPancreatic function and diabetes

Cited by 89

Stimulation of Adenylate Cyclase by Ca2+ and Calmodulin in Rat Islets of Langerhans: Explanation for the Glucose-Induced Increase in Cyclic AMP Levels

Sharp, G. W. G., Wiedenkeller, D. E., Kaelin, D., Siegel, E. G., & Wollheim, C. B. (1980) · Diabetes

Pancreatic function and diabetesPhosphodiesterase function and regulation

Cited by 85

Dynamin-related protein 1 mediates high glucose induced pancreatic beta cell apoptosis

Men, X., Wang, H., Li, M., Cai, H., Xu, S., Zhang, W., Xu, Y., Ye, L., Yang, W., Wollheim, C. B., et al. (2009) · The International Journal of Biochemistry & Cell Biology

Pancreatic function and diabetesMitochondrial Function and Pathology

Cited by 83

Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells

Feldmann, N., del Rio, R. M., Gjinovci, A., Tamarit-Rodriguez, J., Wollheim, C. B., & Wiederkehr, A. (2011) · Molecular and Cellular Endocrinology

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 39