Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases
Open accessAbstract
Tissue fibrosis, characterized by excessive accumulation of aberrant extracellular matrix (ECM) produced by myofibroblasts, is a growing cause of mortality worldwide. Understanding the factors that induce myofibroblastic differentiation is paramount to prevent or reverse the fibrogenic process. Integrin-mediated interaction between the ECM and cytoskeleton promotes myofibroblast differentiation. In the present study, we explored the significance of integrin alpha 11 (ITGA11), the integrin alpha subunit that selectively binds to type I collagen during tissue fibrosis in the liver, lungs and kidneys. We showed that ITGA11 was co-localized with α-smooth muscle actin-positive myofibroblasts and was correlatively induced with increasing fibrogenesis in mouse models and human fibrotic organs. Furthermore, transcriptome and protein expression analysis revealed that ITGA11 knockdown in hepatic stellate cells (liver-specific myofibroblasts) markedly reduced transforming growth factor β-induced differentiation and fibrotic parameters. Moreover, ITGA11 knockdown dramatically altered the myofibroblast phenotype, as indicated by the loss of protrusions, attenuated adhesion and migration, and impaired contractility of collagen I matrices. Furthermore, we demonstrated that ITGA11 was regulated by the hedgehog signaling pathway, and inhibition of the hedgehog pathway reduced ITGA11 expression and fibrotic parameters in human hepatic stellate cells in vitro, in liver fibrosis mouse model in vivo and in human liver slices ex vivo. Therefore, we speculated that ITGA11 might be involved in fibrogenic signaling and might act downstream of the hedgehog signaling pathway. These findings highlight the significance of the ITGA11 receptor as a highly promising therapeutic target in organ fibrosis. A protein involved in binding collagen contributes to the organ-scarring disease known as fibrosis. Integrin alpha 11 (ITGA11) is known to bind collagen produced by myofibroblasts, injury-driven specific cells responsible for inducing fibrosis. A team led by Jai Prakash from the University of Twente in Enschede, The Netherlands, showed that ITGA11 is expressed at higher levels in the livers of mice with experimentally induced fibrosis than in healthy controls. In tissues taken from liver biopsies of fibrosis patients, levels of ITGA11 also tracked the expression of myofibroblasts. Remarkebly, blocking ITGA11 prevented the fibrotic activity of these cells. Similar results were seen in tissue from human fibrotic lung. The findings point to ITGA11 as a promising drug target for treating a range of fibrotic conditions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The decrease in plasma ITGA11 may reflect increased binding of ITGA11 to Col 1 in fibrotic lung tissue.
“ITGA11 selectively binds to Col 1 during fibrogenesis (38); thus, the decrease in plasma ITGA11 may reflect the increased binding of ITGA11 to Col 1 in fibrotic lung tissue.”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [38]
Decreased plasma concentrations of ADAMTS13 were observed in patients with COVID-19.
“Decreased plasma concentrations of ADAMTS13, the natural metalloprotease inhibitor of VWF, were also observed (Fig. 5E) (38).”
From Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19 (2021) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Epithelial-Mesenchymal Transitions in Development and Disease
Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · see citing works
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495 · see citing works
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541 · see citing works
The Versatile Role of microRNA-30a in Human Cancer
Wang, C., Yang, X., Chen, Y., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471111 · Cited by 3,409 · see citing works
Epithelial-mesenchymal transition and its implications for fibrosis
Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,651 · see citing works
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,640 · see citing works
Self-citationBédossa, P. (1994) · Hepatology · doi:10.1002/hep.1840200104 · Cited by 2,189 · see citing works
Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076 · see citing works
Self-citationHinz, B., Phan, S. H., Thannickal, V. J., Galli, A., Bochaton-Piallat, M.-L., & Gabbiani, G. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070112 · Cited by 2,068 · see citing works
Humphries, J. D., Byron, A., & Humphries, M. J. (2006) · Journal of Cell Science · doi:10.1242/jcs.03098 · Cited by 1,711 · see citing works
The myofibroblast in wound healing and fibrocontractive diseases
Gabbiani, G. (2003) · The Journal of Pathology · doi:10.1002/path.1427 · Cited by 1,630 · see citing works
Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis
Humphreys, B. D., Lin, S., Kobayashi, A., Hudson, T. E., Nowlin, B. T., Bonventre, J. V., Valerius, M. T., McMahon, A. P., & Duffield, J. S. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090517 · Cited by 1,447 · see citing works
Integrating mechanisms of pulmonary fibrosis
Wynn, T. A. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110551 · Cited by 1,282 · see citing works
Recent Developments in Myofibroblast Biology
Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., & Gabbiani, G. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.004 · Cited by 1,193 · see citing works
Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
Kramann, R., Schneider, R. K., DiRocco, D. P., Machado, F., Fleig, S., Bondzie, P. A., Henderson, J. M., Ebert, B. L., & Humphreys, B. D. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.11.004 · Cited by 922 · see citing works
Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866 · see citing works
Identification of fibroblast heterogeneity in the tumor microenvironment
Sugimoto, H., Mundel, T. M., Kieran, M. W., & Kalluri, R. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.12.3354 · Cited by 700 · see citing works
Hepatic fibrosis: concept to treatment
Trautwein, C., Friedman, S. L., Schuppan, D., & Pinzani, M. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.02.039 · Cited by 677 · see citing works
Self-citationIntegrin–TGF‐β crosstalk in fibrosis, cancer and wound healing
Margadant, C., & Sonnenberg, A. (2010) · The EMBO Reports · doi:10.1038/embor.2009.276 · Cited by 653 · see citing works
Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
Piera-Velazquez, S., Li, Z., & Jimenez, S. A. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.001 · Cited by 580 · see citing works
Emerging insights into Transforming growth factor Smad signal in hepatic fibrogenesis
Inagaki, Y., & Okazaki, I. (2007) · Gut · doi:10.1136/gut.2005.088690 · Cited by 466 · see citing works
Desmoulière, A., Darby, I. A., & Gabbiani, G. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000101911.53973.90 · Cited by 364 · see citing works
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
Vaira, V., Fedele, G., Pyne, S., Fasoli, E., Zadra, G., Bailey, D., Snyder, E. L., Faversani, A., Coggi, G., Flavin, R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907676107 · Cited by 269 · see citing works
Tiger, C., Fougerousse, F., Grundström, G., Velling, T., & Gullberg, D. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0363 · Cited by 235 · see citing works
Integrin-mediated regulation of TGFβ in fibrosis
Henderson, N. C., & Sheppard, D. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.005 · Cited by 209 · see citing works
Navab, R., Strumpf, D., To, C., Pasko, E., Kim, K. S., Park, C., Hai, J., Liu, J., Jonkman, J. E. N., Barczyk, M., et al. (2015) · Oncogene · doi:10.1038/onc.2015.254 · Cited by 190 · see citing works
Carracedo, S., Lü, N., Popova, S. N., Jonsson, R., Eckes, B., & Gullberg, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078766 · Cited by 145 · see citing works
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic options
Gressner, O. A., Weiskirchen, R., & Gressner, A. M. (2007) · Comparative Hepatology · doi:10.1186/1476-5926-6-7 · Cited by 137 · see citing works
Precision-cut liver slices: A tool to model the liver ex vivo
Olinga, P., & Schuppan, D. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.01.009 · Cited by 119 · see citing works
α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy
Talior‐Volodarsky, I., Connelly, K. A., Arora, P. D., Gullberg, D., & McCulloch, C. A. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs259 · Cited by 110 · see citing works
An Overview of Hedgehog Signaling in Fibrosis
Hu, L., Lin, X., Lu, H., Chen, B., & Bai, Y. (2014) · Molecular Pharmacology · doi:10.1124/mol.114.095141 · Cited by 86 · see citing works
Popova, S. N., Rodríguez‐Sánchez, B., Lidén, Å., Betsholtz, C., van den Bos, T., & Gullberg, D. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.03.006 · Cited by 82 · see citing works
Physiology and pathology of collagen receptors
Popova, S. N., Evy Lundgren-akerlund, B., Wiig, H., & Gullberg, D. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01718.x · Cited by 79 · see citing works
Integrins and cadherins as therapeutic targets in fibrosis
Agarwal, S. K. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00131 · Cited by 71 · see citing works
Honda, E., Yoshida, K., & Munakata, H. (2010) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.220.319 · Cited by 52 · see citing works
Lü, N., Carracedo, S., Ranta, J., Heuchel, R. L., Soininen, R., & Gullberg, D. (2009) · Matrix Biology · doi:10.1016/j.matbio.2009.11.003 · Cited by 52 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019
Dewidar, B., Meyer, C., Dooley, S., & Meindl-Beinker, A. N. (2019) · Cells · doi:10.3390/cells8111419 · Cited by 837 · see citing works
D’Agnillo, F., Walters, K.-A., Xiao, Y., Sheng, Z.-M., Scherler, K., Park, J., Gygli, S., Rosas, L. A., Sadtler, K., Kalish, H., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj7790 · Cited by 237 · see citing works
Drug targeting to myofibroblasts: Implications for fibrosis and cancer
Yazdani, S., Bansal, R., & Prakash, J. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.010 · Cited by 186 · see citing works
Self-citationSchnittert, J., Bansal, R., Storm, G., & Prakash, J. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.01.020 · Cited by 186 · see citing works
Self-citationThe WNT signaling pathways in wound healing and fibrosis
Burgy, O., & Königshoff, M. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.017 · Cited by 182 · see citing works
Integrin signaling in cancer: bidirectional mechanisms and therapeutic opportunities
Li, S., Sampson, C., Liu, C., Piao, H., & Liu, H. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01264-4 · Cited by 162 · see citing works
Mouton, A. J., Ma, Y., Gonzalez, O. J. R., Daseke, M. J., Flynn, E. R., Freeman, T. C., Garrett, M. R., DeLeon‐Pennell, K. Y., & Lindsey, M. L. (2019) · Basic Research in Cardiology · doi:10.1007/s00395-019-0715-4 · Cited by 161 · see citing works
Zheng, H., An, M., Luo, Y., Diao, X., Zhong, W., Pang, M., Lin, Y., Chen, J., Li, Y., Kong, Y., et al. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.02.002 · Cited by 159 · see citing works
The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis
Hintermann, E., & Christen, U. (2019) · Cells · doi:10.3390/cells8121503 · Cited by 87 · see citing works
Zeltz, C., Alam, J., Liu, H., Erusappan, P. M., Hoschuetzky, H., Molven, A., Parajuli, H., Cukierman, E., Costea, D. E., Lü, N., et al. (2019) · Cancers · doi:10.3390/cancers11060765 · Cited by 77 · see citing works
Integrins as a drug target in liver fibrosis
Rahman, S. R., Roper, J. A., Grove, J. I., Aithal, G. P., Pun, K. T., & Bennett, A. J. (2022) · Liver International · doi:10.1111/liv.15157 · Cited by 74 · see citing works
Arctic Fox Influence on a Seabird Community in Labrador: A Natural Experiment
Birkhead, T. R., & Nettleship, D. N. (1995) · Digital Commons - University of South Florida (University of South Florida) · doi:10.5281/zenodo.16493673 · Cited by 66 · see citing works
Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer
Schnittert, J., Bansal, R., Mardhian, D. F., van Baarlen, J., Östman, A., & Prakash, J. (2019) · The FASEB Journal · doi:10.1096/fj.201802336r · Cited by 65 · see citing works
Self-citationIwai, M., Tulafu, M., Togo, S., Kawaji, H., Kadoya, K., Namba, Y., Jin, J., Watanabe, J. A., Okabe, T., Hidayat, M., et al. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12937 · Cited by 54 · see citing works
Targeting collagen homeostasis for the treatment of liver fibrosis: Opportunities and challenges
Luangmonkong, T., Parichatikanond, W., & Olinga, P. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115740 · Cited by 53 · see citing works
Leask, A. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.016 · Cited by 52 · see citing works
Kiss, T., Nyúl‐Tóth, Á., Gulej, R., Tarantini, S., Csípő, T., Mukli, P., Ungvari, A., Balasubramanian, P., Yabluchanskiy, A., Benyó, Z., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00519-1 · Cited by 48 · see citing works
Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair
Lozano, J., Rai, A., Lees, J. G., Fang, H., Claridge, B., Lim, S. Y., & Greening, D. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214334 · Cited by 45 · see citing works
MicroRNAs, endometrial receptivity and molecular pathways
Salmasi, S., Heidar, M. S., Mahabady, M. K., Rashidi, B., & Mirzaei, H. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01304-9 · Cited by 40 · see citing works
The Potential Application of Magnetic Nanoparticles for Liver Fibrosis Theranostics
Eftekhari, A., Arjmand, A., Asheghvatan, A., Švajdlenková, H., Šauša, O., Abiyev, H., Ahmadian, E., Smutok, O. V., Khalilov, R. I., Kavetskyy, T. S., et al. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.674786 · Cited by 40 · see citing works
Ando, T., Kage, H., Matsumoto, Y., Zokumasu, K., Yotsumoto, T., Maemura, K., Amano, Y., Watanabe, K., Nakajima, J., Nagase, T., et al. (2019) · Cancer Science · doi:10.1111/cas.14257 · Cited by 39 · see citing works
Cooperative signaling between integrins and growth factor receptors in fibrosis
Maldonado, H., & Hagood, J. S. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-020-02026-2 · Cited by 37 · see citing works
Transcriptomic and Epigenetic Profiling of Fibroblasts in Idiopathic Pulmonary Fibrosis
Hanmandlu, A., Zhu, L., Mertens, T. C. J., Collum, S., Bi, W., Xiong, F., Wang, R., Amirthalingam, R. T., Ren, D., Han, L., et al. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0437oc · Cited by 37 · see citing works
Rezvani, M., Vallier, L., & Guillot, A. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.01.014 · Cited by 34 · see citing works
Magnetic-Assisted Treatment of Liver Fibrosis
Levada, K. V., Omelyanchik, A. S., Rodionova, V. V., Weiskirchen, R., & Bartneck, M. (2019) · Cells · doi:10.3390/cells8101279 · Cited by 33 · see citing works
Integrin Binding Dynamics Modulate Ligand-Specific Mechanosensing in Mammary Gland Fibroblasts
Lerche, M., Elósegui-Artola, A., Kechagia, Z., Guzmán, C., Γεωργιάδου, Μ., Andreu, I., Gullberg, D., Roca‐Cusachs, P., Peuhu, E., & Ivaska, J. (2020) · iScience · doi:10.1016/j.isci.2020.100907 · Cited by 33 · see citing works
Single-Nuclei RNA-Sequencing of the Gastrocnemius Muscle in Peripheral Artery Disease
Pass, C. G., Palzkill, V. R., Tan, J., Kim, K., Thome, T., Yang, Q., Fazzone, B. J., Robinson, S. T., O’Malley, K. A., Yue, F., et al. (2023) · Circulation Research · doi:10.1161/circresaha.123.323161 · Cited by 31 · see citing works
Zhuang, L., Lu, L., Zhang, R., Chen, K., & Yan, X. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.615161 · Cited by 29 · see citing works
Yokosaki, Y., & Nishimichi, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312794 · Cited by 24 · see citing works
Kumar, V., Dong, Y., Kumar, V., Almawash, S., & Mahato, R. I. (2019) · Theranostics · doi:10.7150/thno.38913 · Cited by 24 · see citing works
Schussler, O., Chachques, J. C., Alifano, M., & Lecarpentier, Y. (2021) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-021-10154-4 · Cited by 21 · see citing works
Yamamura, Y., Sakai, N., Iwata, Y., Lagares, D., Hara, A., Kitajima, S., Toyama, T., Miyagawa, T., Ogura, H., Sato, K., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202201870r · Cited by 20 · see citing works
Self-citationSong, B., Kim, S.-J., Kim, R., Jeong, S., Moon, H., Kim, H., Васильева, Е. А., Mishchenko, N. P., Fedoreyev, S. A., Stonik, V. A., et al. (2022) · Marine Drugs · doi:10.3390/md20120756 · Cited by 19 · see citing works
Implementation of pre-clinical methodologies to study fibrosis and test anti-fibrotic therapy
Oakley, F., Gee, L., Sheerin, N., & Borthwick, L. A. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.10.004 · Cited by 17 · see citing works
TRPV4 regulates β 1 integrin‐mediated cell–matrix adhesions and collagen remodeling
Ji, C., Wang, Y., Wang, Q. L., Wang, A., Ali, A. A., & McCulloch, C. A. (2023) · The FASEB Journal · doi:10.1096/fj.202300222r · Cited by 17 · see citing works
Multi-ancestry meta-analysis of keloids uncovers novel susceptibility loci in diverse populations
Greene, C. A., Hampton, G., Jaworski, J., Shuey, M. M., Khan, A., Luo, Y., Jarvik, G. P., Namjou, B., Edwards, T. L., Edwards, D. R. V., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62945-x · Cited by 16 · see citing works
Single-cell pair-wise relationships untangled by composite embedding model
Subedi, S., & Park, Y. (2023) · iScience · doi:10.1016/j.isci.2023.106025 · Cited by 14 · see citing works
Ma, L., Zhang, C., Gui, Y., Zou, T., Xi, S., & Guo, X. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114626 · Cited by 14 · see citing works
Nowwarote, N., Manokawinchoke, J., Kanjana, K., Fournier, B., Sukarawan, W., & Osathanon, T. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04246 · Cited by 14 · see citing works
Müller, C., Rosmark, O., Åhrman, E., Brunnström, H., Wassilew, K., Nybom, A., Michaliková, B., Larsson, H., Eriksson, L. T., Schultz, H. H. L., et al. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.05.014 · Cited by 13 · see citing works
Li, H., Yang, H., Ma, B., Qiao, J., Chen, F., Wang, P., Yu, R., Sun, J., & Chen, Y. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb00474h · Cited by 12 · see citing works
Yan, X., Liu, T., Zhang, R., Ma, Q., & Sun, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1427970 · Cited by 11 · see citing works
Plummer, R. J., Hu, G., Liu, T., & Yoo, J. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.169 · Cited by 11 · see citing works
Haam, S., Han, J., Lee, H. W., & Koh, Y. W. (2021) · Cancers · doi:10.3390/cancers13174468 · Cited by 11 · see citing works
Simple gene signature to assess murine fibroblast polarization
Ledoult, E., Jendoubi, M., Collet, A., Guerrier, T., Largy, A., Speca, S., Vivier, S., Bray, F., Figeac, M., HACHULLA, E., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-15640-6 · Cited by 10 · see citing works
Hepatic Stellate Cell Targeting Using Peptide-Modified Biologicals
Bansal, R., & Poelstra, K. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3207-9_17 · Cited by 10 · see citing works
Self-citationYang, X., Wu, J., Cai, T., Shan, J., & Cui, Y. (2024) · Cellular Signalling · doi:10.1016/j.cellsig.2024.111286 · Cited by 9 · see citing works
Khalid, J. P., Martin, T. M., Prathap, L., Nisargandha, M. A., Nisha, B., & Kumar, M. S. K. (2024) · Cureus · doi:10.7759/cureus.53949 · Cited by 9 · see citing works
Chandrasegaran, S., Sluka, J. P., & Shanley, D. P. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1012298 · Cited by 8 · see citing works
Effects of alternative splicing events and transcriptome changes on kidney stone formation
Yan, Q., Chen, Y., Liu, H., Li, G., Liang, C. Y., & Hao, Z. (2022) · Urolithiasis · doi:10.1007/s00240-021-01293-z · Cited by 8 · see citing works
Cellular and molecular signals of cardiac wound healing after myocardial infarction
Toba, H., Halade, G. V., DeLeon‐Pennell, K. Y., Chiao, Y. A., Yabluchanskiy, A., Nielsen, S. H., Chalise, U., Becirovic‐Agic, M., Brás, L. E. D. C., & Lindsey, M. L. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00891.2025 · Cited by 7 · see citing works
Chaudhary, P., Yadav, K., Lee, H. J., Kang, K. W., Mo, J., & Kim, J. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01827-4 · Cited by 7 · see citing works
The single-cell atlas of cultured human endometrial stromal cells
Li, R., Wang, T., Shelp-Peck, E., Wu, S., & DeMayo, F. J. (2022) · F&S Science · doi:10.1016/j.xfss.2022.09.001 · Cited by 7 · see citing works
Ju, Y., Huang, L., Wang, S., & Zhao, S. (2020) · Analytical Cellular Pathology · doi:10.1155/2020/6128341 · Cited by 7 · see citing works
ITGA1 Promotes Glioma Cell Proliferation and Affects Immune Cell Infiltration in Low‐Grade Glioma
Ren, Y., Xu, J., Zhang, Z., & Yu, R. (2024) · Mediators of Inflammation · doi:10.1155/2024/6147483 · Cited by 6 · see citing works
Effect of cellular senescence on the response of human peritoneal mesothelial cells to TGF-β
Kawka, E., Herzog, R., Ruciński, M., Malińska, A., Unterwurzacher, M., Sacnun, J. M., Wagner, A., Kowalska, K., Jopek, K., Kucz-Chrostowska, A., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-63250-1 · Cited by 5 · see citing works
Integrins in biliary injury and fibrosis
Schaub, J. R., Chen, J. Y., & Turner, S. (2024) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000995 · Cited by 5 · see citing works
Fang, F., Lyu, J., Lyu, J.-Q., Miao, M.-Y., Gu, J.-M., Qian, Y.-W., Shao, X.-P., Wan, Z.-X., Qin, L.-Q., Yang, J., et al. (2025) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2025.05.020 · Cited by 4 · see citing works
Suhail, Y., Liu, Y., Afzal, J. M., Du, W., Robson, P., Novin, A., Ramasamy, R., & Gupta, K. (2025) · Cells and Development · doi:10.1016/j.cdev.2025.203994 · Cited by 4 · see citing works
Lan, Q., Liufu, S., Xu, X., Chen, B., Chen, W., Wang, K., Liu, C., Xiao, L., Liu, X., Yi, L., et al. (2025) · BMC Genomics · doi:10.1186/s12864-025-11896-0 · Cited by 4 · see citing works
Deleersnijder, D., Venken, T., Schepers, R., Brussel, T. V., Meijers, B. K. I., Sprangers, B., Lambrechts, D., & Craenenbroeck, A. H. V. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.06.023 · Cited by 3 · see citing works
Integrin α11: Key signaling pathways and tumor dynamics
Sankar, R., John, S., Sharma, K., Devi, P., Chundawat, P., & Gupta, S. (2024) · Journal of Oral and Maxillofacial Surgery Medicine and Pathology · doi:10.1016/j.ajoms.2024.12.012 · Cited by 3 · see citing works
Sudhindar, P. D., Olinger, E. G., Sentell, Z. T., Mabillard, H. R., Dicka, B., Wood, K. M., Rutland, D., Collins, C., Trevisán-Herraz, M., Sayer, J. A., et al. (2025) · Journal of Cell Science · doi:10.1242/jcs.264141 · Cited by 3 · see citing works
α11β1: A Mesenchymal Collagen-Binding Integrin with a Central Role in Tissue and Tumor Fibrosis
Zeltz, C., & Gullberg, D. (2023) · Biology of extracellular matrix · doi:10.1007/978-3-031-23781-2_7 · Cited by 3 · see citing works
Zhou, L., Hou, Y., Pan, X., Wang, X. B., Jin, H., Yang, X., Wang, K., Ding, X., Wang, K., Zhu, M., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111081 · Cited by 3 · see citing works
Li, X., Rong, K., Huang, Y., Zhao, Z., Xu, C., Li, L., Zhang, Y., Yan, Y., Huang, W., Zhang, Y., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202500432r · Cited by 2 · see citing works
Lee, D., Kim, J. H., & Lee, D. Y. (2025) · Clinical and Experimental Nephrology · doi:10.1007/s10157-025-02774-w · Cited by 2 · see citing works
Liu, S., Xie, K., Zhao, H., Sun, Y., Song, X., Xu, L., Yan, Y., Wang, T., Nyoja, S., Gao, J., et al. (2026) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2026.111974 · Cited by 2 · see citing works
A single-cell atlas revealing cellular heterogeneity across healthy and diseased human thymus
Direder, M., Wielscher, M., Salek, M., Laggner, M., Copic, D., Klas, K., Bormann, D., Golabi, B., Kühtreiber, H., Lingitz, M., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72760-7 · Cited by 2 · see citing works
Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis
Shi, Z., & Rockey, D. C. (2026) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-026-01223-7 · Cited by 2 · see citing works
Targeting Fibroblasts in Fibrosis and Cancer
Mostafa, A. M. R. H., Bansal, R., & Prakash, J. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015783-00307 · Cited by 2 · see citing works
Self-citationIntegrins: Key Targets in Tissue Fibrosis and Tumor Stroma
Veerman, D., & Prakash, J. (2023) · Biology of extracellular matrix · doi:10.1007/978-3-031-23781-2_3 · Cited by 2 · see citing works
Self-citationRôle des intégrines dans la fibrose cardiaque
Delacroix, C., & Hulot, J. (2022) · médecine/sciences · doi:10.1051/medsci/2022055 · Cited by 2 · see citing works
Wang, X., Wang, C., Cui, Z., Jiang, Y., Zheng, Z., Liu, Y., & Wang, Z. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111042 · Cited by 1 · see citing works
Wang, Z., Wu, Q., Yao, Y., Cao, M., Ding, J., Xiao, Y., Huang, X., & Luo, J. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116793 · Cited by 1 · see citing works
Meyer, F., Traidl, S., Ameri, M., Dreher, A., Abu-Rashed-Kufs, N., Vontobel, J., Möhrenschlager, M., Duchna, H. W., Sandberg, F., & Brüggen, M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0338451 · Cited by 1 · see citing works
The landscape of allele-specific expression in human kidneys
Onuchic-Whitford, A. C., Sung, J.-M., Sakkas, E. D., McNulty, M., Mezger, V., O'Connor, C. L., Greenberg, A., Yoon, J. G., Badina, S., Mariani, L. H., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeg3462 · Cited by 1 · see citing works
PDE4 inhibition: a novel therapeutic strategy in liver fibrosis.
Elnagdy, M. (2021) · doi:10.18297/etd/3611 · Cited by 1 · see citing works
Comprehensive network analysis of integrin α11 expressed in human breast cancerPreprint
Fu, Y., Sun, X., & Zhuang, Z. (2019) · Research Square · doi:10.21203/rs.2.15539/v1 · Cited by 1 · see citing works
Targeting and modulation of the tumor stroma in pancreatic cancer
Schnittert, J. (2018) · doi:10.3990/1.9789036545853
Meehan, D. T., Brockhouse, J., Connell, K., Madison, J., Gratton, M. A., & Cosgrove, D. E. (2025) · Hearing Research · doi:10.1016/j.heares.2025.109383
Shin, J., Leem, S., Ha, S. H., Seo, J. Y., Gu, K., Jeong, E. T., Kim, Y., & Kang, N. G. (2025) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2025.08.010
Chaudhary, P., Yadav, K., Lee, H. J., Kang, K. W., Mo, J., & Kim, J.-A. (2024) · Figshare · doi:10.6084/m9.figshare.25698427
Chaudhary, P., Yadav, K., Lee, H. J., Kang, K. W., Mo, J., & Kim, J.-A. (2024) · Figshare · doi:10.6084/m9.figshare.25698183
TGF ‐β‐Dependent α11 Integrin Expression Is Reduced in Aging Gingival Wounds
Ríos, S., Wang, Y., Valeria Muñoz, L., Narea, G., Martínez, C. L., Farías, O., López, R. P., Martínez, J. E., Hernández, P., Tobar, N., et al. (2026) · Wound Repair and Regeneration · doi:10.1111/wrr.70122
Qin, J., Zhang, H., Li, Z., Zhang, D., Xie, Y., Li, J., Dou, M., Cao, M., Yang, X., Luo, Z., et al. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c05284
MicroRNA-mediated transgenerational plasticity reveals pathways for ocean warming resiliencePreprint
Bonzi, L. C., Donelson, J. M., Shimada, R. K., Munday, P. L., Ravasi, T., & Schunter, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.21.727062
MRC2 Links Collagen Turnover to Integrin/PI3K/AKT‐Driven Fibrogenesis
Suntornnont, N., Sapudom, J., & Ariyachet, C. (2026) · Advanced Biology · doi:10.1002/adbi.70133
Cheng, L., Yu, J., Chen, H., Xiang, M., Yang, W., Wang, C., Yan, R., Deng, T., & Liu, C. (2026) · Journal of Animal Science · doi:10.1093/jas/skag202
Burn Injury Rewires Immune and Neuronal Extracellular Vesicle Communication
Grimsrud, K., Green, T., Tang, Y., Clayton, S. M., Ward, B. M., Wang, D., Durbin-Johnson, B. P., Wang, A., & Palmieri, T. L. (2026) · Annals of Surgery · doi:10.1097/sla.0000000000007161
Targeting Integrins in Immunity: Precision Matters for Therapeutic Interventions
Ahmed, A. U. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl47669
Kaur, E., Holt, J. A., Wilson, R., Kelly, V., Marin, E. G., Žunar, B., Daniels, A., Adib, R., Thomas, P., Lenhard, B., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.29.748043
Proteomic Signatures Associated With Life-Threatening Arrhythmic Events in Brugada Syndrome
Furutani, M., Nakashima, M., Miyamoto, S., Miyauchi, S., Okamura, S., Okubo, Y., Tokuyama, T., Oda, N., Shigemizu, D., & Nakano, Y. (2026) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2026.06.027
- Authors
- Bansal, R., Nakagawa, S., Yazdani, S., van Baarlen, J., Venkatesh, A., Koh, A. P., Song, W.-M., Goossens, N., Watanabe, H., Beasley, M. B., Powell, C. A., Storm, G., Kaminski, N., van Goor, H., Friedman, S. L., Hoshida, Y., & Prakash, J.
- Affiliations
- University of Twente (NL)
- Tisch Cancer Institute (US)
- Harvard University (US)
- Icahn School of Medicine at Mount Sinai (US)
- Utrecht University (NL)
- Yale University (US)
- Karolinska Institutet (SE)
- Corresponding author
- Bansal, Ruchi
- Prakash, Jai
- ORCID
- Venue
- Experimental & Molecular Medicine
- Published
- 2017-11
- Volume
- 49
- Issue
- 11
- Pages
- e396-e396
- ISSN
- 1226-3613 (ISSN-L)
- 2092-6413
- PMC
- PMC5704196
- OpenAlex
- W2769870963
- Cited by
- 96
- References
- 38
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 12 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 6 · 2019: 12 · 2018: 4 · 2017: 1
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental & Molecular Medicine (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- University of Twente Research Information (acceptedVersion, cc-by-nc-sa)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-sa)
- University of Twente Research Information (submittedVersion, other-oa)
- Funders
- Irma T. Hirschl Trust
- ZonMw (916.151.94)
- Nierstichting (14OI16)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Vetenskapsrådet (2011-5389)
- National Institutes of Health (DK56621)
- National Cancer Institute (R01CA163772)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK056621, R01DK099558, R01DK056621, DK099558, DK 56621)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Keywords
- myofibroblast differentiation, fibrosis, liver fibrosis, hepatic stellate cells, Hedgehog signaling, type I collagen, TGF-beta, extracellular matrix, alpha-smooth muscle actin, cell adhesion and migration, organ fibrosis, fibrotic diseases
- MeSH terms
- Animals, Cell Differentiation, Disease Models, Animal, Fibrosis, Gene Expression Regulation, Humans, Immunohistochemistry, Kidney Diseases, Liver Cirrhosis, Phenotype, Signal Transduction, Transforming Growth Factor beta, Integrin alpha Chains, Mice, Hedgehog Proteins, Hepatic Stellate Cells, Gene Knockdown Techniques, Myofibroblasts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
