Chromosomal dynamics of nucleolar organizer regions (NORs) in the house mouse: micro-evolutionary insights
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Variation in the number and chromosomal location of nucleolar organizer regions (NORs) was studied in the house mouse, Mus musculus (2n=40). From an origin in Western Asia, this species colonized the Middle East, Europe and Asia. This expansion was accompanied by diversification into five subspecies. NOR diversity was revealed by fluorescence in situ hybridization using 18S and 28S probes on specimens spanning Asia to Western Europe. The results showed that the house mouse genome possessed a large number of NOR-bearing autosomes and a surprisingly high rate of polymorphism for the presence/absence of rRNA genes on all these chromosomes. All NOR sites were adjacent to the centromere except for two that were telomeric. Subspecific differentiation established from the NOR frequency data was concordant with the overall pattern of radiation proposed from molecular studies, but highlighted several discrepancies that need to be further addressed. NOR diversity in M. musculus consisted of a large number of polymorphic NORs that were common to at least two subspecies, and a smaller number of NORs that were unique to one subspecies. The most parsimonious scenario argues in favor of a subspecific differentiation by lineage sorting of ancestral NOR polymorphisms; only the unique NORs would have appeared by inter-chromosomal transposition, except for the two telomeric ones that may have originated by hybridization with another species. Such a scenario provides an alternative view from the one prevailing in most systematic and phylogenetic analyses that NORs have a high transposition rate due to concerted evolution of rRNA genes.
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Distributions of chromosomal conformations suggest preferential contacts of Nucleolar Organiser Regions (NOR, P<0.01).
“Finally, distributions of chromosomal conformations also suggest preferential contacts of Nucleolar Organiser Regions19 (NOR, P < 0.01 one-sided MW test”
From Cell-cycle dynamics of chromosomal organization at single-cell resolution (2017) · cites this paper as [19]
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- Authors
- Britton-Davidian, J., Cazaux, B., & Catalan, J.
- Affiliations
- Institut des Sciences de l'Evolution de Montpellier (FR)
- Venue
- Heredity
- Published
- 2011-11-16
- Volume
- 108
- Issue
- 1
- Pages
- 68-74
- ISSN
- 0018-067X (ISSN-L)
- 1365-2540
- PMC
- PMC3238117
- OpenAlex
- W2056173514
- Cited by
- 65
- References
- 42
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 2 · 2014: 9 · 2013: 2 · 2012: 1
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heredity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- nucleolar organizer regions, ribosomal DNA, house mouse, Mus musculus, subspecies differentiation, chromosomal polymorphism, lineage sorting, nucleic acid hybridization, concerted evolution, centromere
- MeSH terms
- Animals, Nucleolus Organizer Region, Phylogeny, Polymorphism, Genetic, Genetic Variation, In Situ Hybridization, Fluorescence, Evolution, Molecular, Genes, rRNA, Chromosomes, Mammalian, Mice
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