The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bias in the αβ T‐cell repertoire: implications for disease pathogenesis and vaccination
Open accessAbstract
The naïve T‐cell repertoire is vast, containing millions of unique T‐cell receptor (TCR) structures. Faced with such diversity, the mobilization of TCR structures from this enormous pool was once thought to be a stochastic, even chaotic, process. However, steady and systematic dissection over the last 20 years has revealed that this is not the case. Instead, the TCR repertoire deployed against individual antigens is routinely ordered and biased. Often, identical and near‐identical TCR repertoires can be observed across different individuals, suggesting that the system encompasses an element of predictability. This review provides a catalog of αβ TCR bias by disease and by species, and discusses the mechanisms that govern this inherent and widespread phenomenon.
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Cites
A Direct Estimate of the Human αβ T Cell Receptor Diversity
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P. (1999) · Science · doi:10.1126/science.286.5441.958 · Cited by 931
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Britanova, O. V., Putintseva, E. V., Shugay, M., Merzlyak, E. M., Turchaninova, M. A., Staroverov, D. B., Bolotin, D. A., Lukyanov, S., Bogdanova, E. A., Mamedov, I. Z., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302064 · Cited by 465
Overview of methodologies for T-cell receptor repertoire analysis
Rosati, E., Dowds, C. M., Liaskou, E., Henriksen, E. K. K., Karlsen, T. H., & Franke, A. (2017) · BMC Biotechnology · doi:10.1186/s12896-017-0379-9 · Cited by 322
Estimating T-cell repertoire diversity: limitations of classical estimators and a new approach
Laydon, D. J., Bangham, C. R. M., & Asquith, B. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0291 · Cited by 215
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Metadata
- Authors
- Miles, J. J., Douek, D. C., & Price, D. A.
- Venue
- Immunology & Cell Biology
- Publisher
- Wiley
- Published
- 2011-02-08
- Volume
- 89
- Issue
- 3
- Pages
- 375-387
- ISSN
- 0004-945X (ISSN-L)
- 0818-9641
- 1440-1711
- OpenAlex
- W2121555036
- Cited by
- 199
- References
- 1
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miles, J. J., Douek, D. C., & Price, D. A. (2011). Bias in the αβ T‐cell repertoire: implications for disease pathogenesis and vaccination. Immunology & Cell Biology. https://doi.org/10.1038/icb.2010.139
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