Cited by 936T-cell and B-cell ImmunologyMonoclonal and Polyclonal Antibodies ResearchArtificial Immune Systems Applications

A Direct Estimate of the Human αβ T Cell Receptor Diversity

Arstila, T. Petteri, Casrouge, Armanda, Baron, Véronique, Even, Jos, Kanellopoulos, Jean, Kourilsky, Philippe·1999·Science

Abstract

Generation and maintenance of an effective repertoire of T cell antigen receptors are essential to the immune system, yet the number of distinct T cell receptors (TCRs) expressed by the estimated 10 12 T cells in the human body is not known. In this study, TCR gene amplification and sequencing showed that there are about 10 6 different β chains in the blood, each pairing, on the average, with at least 25 different α chains. In the memory subset, the diversity decreased to 1 × 10 5 to 2 × 10 5 different β chains, each pairing with only a single α chain. Thus, the naı̈ve repertoire is highly diverse, whereas the memory compartment, here one-third of the T cell population, contributes less than 1 percent of the total diversity.

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Crossref · 10.1126/science.286.5441.958

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  • Early studies estimated the human TCR repertoire contains about 10^6 different TRB gene nucleotide sequences.

    “the human TCR repertoire entails approximately 106 different TRB gene nucleotide sequences”

    From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Arstila et al., 1999

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Authors
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P.
Affiliations
  • Inserm (FR)
  • Unité de Biologie Moléculaire du Gène, INSERM U277, Institut Pasteur, 75724 Paris Cedex 15, France.
Corresponding author
Arstila, T. Petteri
Venue
Science
Published
1999-10-29
Volume
286
Issue
5441
Pages
958-961
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2105381977
Cited by
931
References
30
Citations by year
2026: 25 · 2025: 28 · 2024: 29 · 2023: 24 · 2022: 26 · 2021: 32 · 2020: 57 · 2019: 42 · 2018: 42 · 2017: 38 · 2016: 51 · 2015: 45 · 2014: 42 · 2013: 49 · 2012: 49
FWCI
8.21
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Physical Sciences › Engineering › Biomedical Engineering › Artificial Immune Systems Applications
Keywords
T cell receptor diversity, alpha beta T cells, T cell receptor repertoire, T cell receptor beta chain, TCR alpha chain, T cell memory, naive T cells, T cell receptor
MeSH terms
Adult, Female, Gene Amplification, Humans, Immunologic Memory, Male, T-Lymphocytes, Genetic Variation, Gene Rearrangement, T-Lymphocyte, Receptors, Antigen, T-Cell, alpha-beta

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