HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

Cited by (477)

Items 401–477 of 477

1. Regulation of canonical Wnt/β-catenin pathway in the nucleus
   Wenxiao Han, Hongying Wang · 2014 · Chinese Science Bulletin
2. Evaluation of 6-([18F] fluoroacetamido)-1-hexanoic-anilide (18F-FAHA) as imaging probe in tumor xenograft mice model
   Fiona Li, Sung Ju Cho, Lihai Yu, Robert H. E. Hudson, Leonard G. Luyt, Christopher L. Pin, Michael S. Kovacs, James D. Koropatnick, Ting‐Yim Lee · 2016 · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE
3. DNA Methylation: A Possible Target for Current and Future Studies on Cancer?
   Sahar Olsadat Sajadian, Andreas Klaus Nussler · 2015 · Epigenetic Diagnosis & Therapy
4. Target Cancer Therapy
   Taciane Ladislau, P Klesia, Di Stefano Renata, Isabella dos Santos Guimarães, Sarah Ftouni, Paulo CM, C Iuri, Leticia BA, L Alice · 2013 · InTech eBooks
5. The Future Prospect of Targeted Therapy in Hepatocellular Carcinoma
   Stephanie H. Greco, K. Spencer, D. Carpizo · 2018 · Molecular pathology library
6. Expression profile of stem cell pathway genes in patients with advanced breast cancer after neoadjuvant therapy
   Syarifah Dewi, Ramadhan Karsono, Setia Pramana, Septelia Inawati Wanandi · 2018 · Journal of Physics Conference Series
7. The effect of valproic acid on SLC5A8 expression in gonad-intact and gonadectomized rat thymocytes
   Milda Juknevičienė, Ingrida Balnytė, Angelija Valančiūtė, Jūratė Stanevičiūtė, Kęstutis Sužiedėlis, Donatas Stakišaitis · 2022 · International Journal of Immunopathology and Pharmacology
8. Towards the Development of Tropolone Natural Product Derivatives as Novel, Potent Anticancer Therapeutics that Selectively Target Histone Deacetylase (HDAC) Enzymes
   Sophia N. Ononye · 2013 · OpenCommons at University of Connecticut (University of Connecticut)
9. Correction: Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo
   Han-Li Huang, Hsueh‐Yun Lee, An-Chi Tsai, Chieh-Yu Peng, Mei-Jung Lai, Jing-Chi Wang, Shiow‐Lin Pan, Che‐Ming Teng, Jing‐Ping Liou · 2012 · PLoS ONE
10. Reevaluating the Concept of Aging: Long-Term Stress Adaptation as a Key Factor in Yeast Aging
    Yanzhuo Kong, Damola O. Adejoro, Christopher S. Winefield, Stephen L. W. On, Philip A. Wescombe, Arvind Subbaraj, Andrew Saunders, Venkata Chelikani · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
11. O envolvimento da remodelação da cromatina no controle do comportamento agressivo dos carcinomas epidermoides de cabeça e pescoço
    Fernanda Salgueiredo Giudice · 2012
12. Rectal Cancer – Functional Molecular Profiling and Targeting of Tumor Hypoxia in Radiation Response and Metastasis
    Marie Grøn Sælen · 2014 · NORA - Norwegian Open Research Archives
13. Genetic Basis of Metastasis
    Catherine A. Moroski-Erkul, Esin Demir, Esra Gündüz, Mehmet Gündüz · 2015 · Springer eBooks
14. Evaluation of Photoreactive and Phenothiazine-based HDAC Inhibitors
    Antonett Madriaga · 2014 · Figshare
15. The Desmosomal Protein Desmoglein 1 Aids Recovery of Epidermal Differentiation after Acute UV Light
    Exposure L. Johnson, Jennifer Leigh Koetsier, Anna Sirico, Ada T. Agidi, Dario Antonini, Kathleen Janee Green · 2014
16. Chapter 11 Zyfl amend and Prostate Cancer Therapy
    Jay N. Whelan, Yi Zhao, E‐Chu Huang, Amber MacDonald, Dallas R. Donohoe · 2016 · Traditional herbal medicines for modern times
17. Original article: HDAC INHIBITORS, MS-275 AND SALERMIDE, POTENTIATES THE ANTICANCER EFFECT OF EF24 IN HUMAN PANCREATIC CANCER CELLS
    Atiye Seda, Yar Saglam, Hacer İlke Önen, Ebru Alp, Handan Kayhan, Abdullah Ekmekçi · 2016
18. Molecular mechanisms of HDAC inhibitor-resistance in lymphoid malignancies determined by two-dimensional difference gel electrophoresis
    Kazuyasu Fujii · 2015 · SEIBUTSU BUTSURI KAGAKU
19. Estudio de la ruta de la autofagia en carcinoma de endometrio esporádico
    Marta Fernández Prieto · 2016
20. Mechanistic approaches for reactivation and elimination of latent HIV-1
    Alyssa R. Martin · 2017
21. Oncostatin M Promotes Breast Cancer Metastasis: Increased Expression of Pro-Angiogenic Factors, Inflammatory Cytokine Expression, and Circulating Tumor Cell Numbers
    Ken Tawara · 2017
22. A Multi-Pronged Modulation of Signaling Pathways in Targeting Breast Cancer Stem Cells.
    Hsiu-Fang Lee · 2012 · Deep Blue (University of Michigan)
23. Classical And Ab Initio Qm/mm Simulations Of Bacterial Enzymes
    Sajeewa W. Dewage · 2015
24. Targeted Therapies in Mesothelioma
    Loredana Urso, Giulia Pasello · 2019 · Springer eBooks
25. Role of histone acetylation and DNA methylation in hepatic inflammatory response
    Yao Wang, Zuojiong Gong · 2019 · World Chinese Journal of Digestology
26. [Histone modification aberrations in acute myeloid leukemia and the target therapy development in clinical settings].
    Huidong Guo, Yajing Chu, Weiping Yuan · 2018 · PubMed Central
27. Epigenetics
    Akihiro Ito, Minoru Yoshida · 2017 · Springer eBooks
28. Effect of Histone Deacetylase Inhibitor to Osteosarcoma through Specificity Protein 1/ Phospholipase D1 Pathway
    D. CAI, T. YUAN, Zhen Jin, JIAN QIN · 2020 · Indian Journal of Pharmaceutical Sciences
29. Investigational new drugs against glioblastoma
    David Olayinka. Kamson, Harmon Singh Khela, John Laterra · 2021 · Elsevier eBooks
30. Insights into the Regulatory Activities of Chromatin Through Computational Analyses of Whole-Genome Data
    Stephen A. Hoang · 2013
31. Ibrutinib Combined With Low-Dose HDAC Inhibitor Chidamide Synergistically Enhances the Anti-Tumor Effect in B-Cell Lymphoma
    Hui Yu, Lan Mi, Weimin Zhang, Yingying Ye, Miaomiao Li, Dingyao Hu, Jiaowu Cao, Dedao Wang, Xiaogan Wang, Ning Ding et al. · 2022 · SSRN Electronic Journal
32. A combination of repurposed drugs reduces the proliferation and viability of glioblastoma cells
    Alexandra Sachkova · 2021
33. Regulatory landscape in the approval of cancer vaccine
    Kamya Goyal, Bharti Mangla, Navdeep Singh, Honey Goel, Kunal Goyal, Shammy Jindal, Mohammad Javed Ansari, Waleed Hassan Almalki · 2022 · Elsevier eBooks
34. Genetic Basis of Metastasis
    Catherine A. Moroski-Erkul, Esin Demir, Esra Gündüz, Mehmet Gündüz · 2019 · Springer eBooks
35. Data from Alteration of MDM2 by the Small Molecule YF438 Exerts Antitumor Effects in Triple-Negative Breast Cancer
    Peipei Shan, Feifei Yang, Hongzhao Qi, Yunjie Hu, Sujie Zhu, Zhenqing Sun, Zhe Zhang, Chuanxiao Wang, Caixia Hou, Jie Yu et al. · 2023
36. Macrophage metabolic reprogramming in chronic diseases
    Sara Lucia Maria Lo Russo · 2024
37. MYC plus class IIa HDAC inhibition potentiates mitochondrial dysfunction in non-small cell lung cancer
    Jina Park, Ying-Yu Chen, Jennie J. Cao, Julia An, Ray-Whay Chiu Yen, John D. Outen, Stephen B. Baylin, Michael J. Topper · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
38. Pharmacoepigenetics of histone deacetylase inhibitors in cancer
    Christos Damaskos, Nikolaos Garmpis, Dimitrios Dimitroulis, Anna Garmpi, Serena I. Valsami, Eleni I. Effraimidou, Gregory P. Kouraklis · 2025 · Elsevier eBooks
39. Inhibition of Histone Deacetylases Induces Cancer Cell Apoptosis Through the PERK Pathway of ER Stress Response
    Xuan Wang, Caiyun Yang, Yili Yang, Feng Xu, Donglan Yuan, Yuexi Gu · 2025 · Journal of Cellular and Molecular Medicine
40. A histone acetylation score for prognostic stratification and immunogenomic profiling in esophageal cancer
    Chanyuan Fan, Kailun Sun, Zhaoyan Feng, Peipei Zhang, Xueping Yang, Xiangde Min · 2025 · Discover Oncology
41. The radiosensitizing effects of a STAT3/HDAC dual-target inhibitor derived from isoalantolactone in solid tumor models
    Qi Wang, Haiyan Qiu, Rongfei Zhu, Rong Li, Jiahan Qiao, Chun Fu, Yaxin Tang, Aihua Shen, Junfang Yan, Denggao Zhao et al. · 2026 · BMC Cancer
42. UHRF1 inhibitors targeting the epigenetic patterns in cancer cells
    Liliyana Zaayter · 2018 · theses.fr (ABES)
43. Generation of oxidative stress as an anticancer therapeutic strategy : Investigating the mechanism of action of vitamin C, auranofin and their combination
    Nadine El Banna · 2019
44. Perturbation par l'éthanol de la plasticité synaptique reliée aux sous-unités GluN2A et GluN2B dans l'hippocampe chez le rongeur : implication des HDAC2 et HSF2
    Ichrak Drissi · 2018 · theses.fr (ABES)
45. Long‐Term Stress Adaptation as a Highly‐Conserved Key Factor in Yeast Aging
    Yanzhuo Kong, Damola O. Adejoro, Christopher S. Winefield, Stephen L. W. On, Philip A. Wescombe, Arvind Subbaraj, Andrew Saunders, Venkata Chelikani · 2026 · Aging Cell
46. Expression Levels of DNMT1, HDAC1, and MT1E Genes as Diagnostic Biomarkers for Breast Cancer Clinicopathological Features: In Vitro and In Silico Analyses
    Sedigheh Akhtartavan, Hamid Madanchi, Raheb Ghorbani, Abolfazl Khalafi‐Nezhad, A M Abdullahi, Fahimeh Shamsi, Hossein Heli · 2026 · Analytical Cellular Pathology
47. Re-examining the necessity of natural products in cancer therapy: Challenges and future perspectives
    Patel Kirtankumar Manishkumar, Sudani Vaibhav Rameshbhai, Aman Kumar Mandal, Bhumika Patel, Chetana Deoghare, Om Prakash Patel · 2026 · Pharmacological Research - Natural Products
48. BindingDB Entry 50042425: Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.
    BindingDB · 2013 · UC San Diego
49. BindingDB Entry 50008864: Discovery of novel 9H-purin derivatives as dual inhibitors of HDAC1 and CDK2.
    BindingDB · 2021 · UC San Diego
50. BindingDB Entry 50042694: Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
    BindingDB · 2013 · UC San Diego
51. BindingDB Entry 50044721: ST7612AA1, a thioacetate-¿(¿-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors.
    BindingDB · 2016 · UC San Diego
52. BindingDB Entry 50021384: Discovery of Novel HDAC3 Inhibitors with PD-L1 Downregulating/Degrading and Antitumor Immune Effects.
    BindingDB · 2025 · UC San Diego
53. BindingDB Entry 50042373: Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
    BindingDB · 2013 · UC San Diego
54. BindingDB Entry 7728: Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.
    BindingDB · 2017 · UC San Diego
55. BindingDB Entry 50023513: Discovery of the First-in-Class Dual-Target ROCK/HDAC Inhibitor with Potent Antitumor Efficacy in Vivo That Trigger Antitumor Immunity.
    BindingDB · 2026 · UC San Diego
56. BindingDB Entry 50013409: Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
    BindingDB · 2022 · UC San Diego
57. BindingDB Entry 50008152: Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.
    BindingDB · 2021 · UC San Diego
58. BindingDB Entry 50000278: Class I HDAC Inhibitors Display Different Antitumor Mechanism in Leukemia and Prostatic Cancer Cells Depending on Their p53 Status.
    BindingDB · 2019 · UC San Diego
59. BindingDB Entry 50002824: Incorporation of histone deacetylase inhibitory activity into the core of tamoxifen - A new hybrid design paradigm.
    BindingDB · 2020 · UC San Diego
60. BindingDB Entry 50044935: Aurones as histone deacetylase inhibitors: identification of key features.
    BindingDB · 2016 · UC San Diego
61. BindingDB Entry 50008456: Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
    BindingDB · 2021 · UC San Diego
62. BindingDB Entry 7155: An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
    BindingDB · 2016 · UC San Diego
63. BindingDB Entry 50047786: Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
    BindingDB · 2017 · UC San Diego
64. BindingDB Entry 50006385: Design, synthesis and evaluation of antiestrogen and histone deacetylase inhibitor molecular hybrids.
    BindingDB · 2020 · UC San Diego
65. BindingDB Entry 50049021: Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors.
    BindingDB · 2019 · UC San Diego
66. BindingDB Entry 50000279: Discovery of N1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer.
    BindingDB · 2019 · UC San Diego
67. BindingDB Entry 50017522: Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer.
    BindingDB · 2023 · UC San Diego
68. BindingDB Entry 50040017: Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
    BindingDB · 2013 · UC San Diego
69. BindingDB Entry 50015233: Discovery of phthalazino[1,2-b]-quinazolinone derivatives as multi-target HDAC inhibitors for the treatment of hepatocellular carcinoma via activating the p53 signal pathway.
    BindingDB · 2023 · UC San Diego
70. BindingDB Entry 50017951: Comprehensive review for anticancer hybridized multitargeting HDAC inhibitors.
    BindingDB · 2023 · UC San Diego
71. BindingDB Entry 50043985: Total synthesis of burkholdacs A and B and 5,6,20-tri-epi-burkholdac A: HDAC inhibition and antiproliferative activity.
    BindingDB · 2014 · UC San Diego
72. BindingDB Entry 50040629: Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
    BindingDB · 2013 · UC San Diego
73. BindingDB Entry 50005777: Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp.
    BindingDB · 2020 · UC San Diego
74. BindingDB Entry 50009975: Synthesis and biological evaluation of santacruzamate A analogues for anti-proliferative and immunomodulatory activity.
    BindingDB · 2021 · UC San Diego
75. BindingDB Entry 50016088: Selective inhibition of histone deacetylase 3 by novel hydrazide based small molecules as therapeutic intervention for the treatment of cancer.
    BindingDB · 2023 · UC San Diego
76. BindingDB Entry 50047160: Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.
    BindingDB · 2017 · UC San Diego
77. A Study of Histone Deacetylase Inhibitors: Determination of the Binding Energetics of Suberoylanilide Hydroxamic Acid with Zinc and Cobalt and Preliminary Screening of Nitric Oxide Donors
    Erin Gallagher · 2012 · Digital Commons-DePaul (DePaul University)