STAT1 plays a role in TLR signal transduction and inflammatory responses

Pathogen Recognition and Innate Immunity

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Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

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Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

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Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

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LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF

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Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2

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A Regulatory Feedback between Plasmacytoid Dendritic Cells and Regulatory B Cells Is Aberrant in Systemic Lupus Erythematosus

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Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

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Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways

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TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury

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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

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Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation

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MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

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A Cell-Intrinsic Interferon-like Response Links Replication Stress to Cellular Aging Caused by Progerin

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TRAF Molecules in Inflammation and Inflammatory Diseases

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Comprehensive gene and pathway analysis of cervical cancer progression

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TET2 Regulates the Neuroinflammatory Response in Microglia

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Recent advances in endotoxin tolerance

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Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis

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A Cytokine Signalling Network for the Regulation of Inducible Nitric Oxide Synthase Expression in Rheumatoid Arthritis

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Myricitrin Modulates NADPH Oxidase‐Dependent ROS Production to Inhibit Endotoxin‐Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47phox Pathways

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The skin transcriptome in hidradenitis suppurativa uncovers an antimicrobial and sweat gland gene signature which has distinct overlap with wounded skin

Coates, M., Mariottoni, P. R. C. G. B., Corcoran, D. L., Fradin, H., Jaleel, T., Brown, D. A., Brooks, S. R., Murray, J. C. S., Morasso, M. I., & MacLeod, A. S. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216249 · Cited by 77

Minor Ginsenoside Rg2 and Rh1 Attenuates LPS-Induced Acute Liver and Kidney Damages via Downregulating Activation of TLR4-STAT1 and Inflammatory Cytokine Production in Macrophages

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Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities

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The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity

Ramirez‐Ortiz, Z. G., Prasad, A., Griffith, J. W., Pendergraft, W. F., Cowley, G. S., Root, D. E., Tai, M., Luster, A. D., Khoury, J. B. E., Hacohen, N., et al. (2015) · Nature Immunology · doi:10.1038/ni.3143 · Cited by 75

Ischemia/reperfusion induces interferon stimulated gene expression in microglia

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Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection‐Induced Preterm Birth

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Ubiquitin‐dependent regulation of Foxp3 and Treg function

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Toll-like receptor 4 plays a key role in advanced glycation end products-induced M1 macrophage polarization

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Mechanism of mesenchymal stem cells in spinal cord injury repair through macrophage polarization

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SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Cells

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Causes and consequences of genomic instability in laminopathies: Replication stress and interferon response

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Abnormal regulation of fibronectin production by fibroblasts in psoriasis

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Mechanism by which TRAF6 Participates in the Immune Regulation of Autoimmune Diseases and Cancer

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Current and Emerging Evidence for Toll-Like Receptor Activation in Sjögren’s Syndrome

Kiripolsky, J., & Kramer, J. M. (2018) · Journal of Immunology Research · doi:10.1155/2018/1246818 · Cited by 58

Signaling pathways and targeted therapy for rosacea

Yang, F., Wang, L., Song, D., Zhang, L., Wang, X., Du, D., & Jiang, X. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1367994 · Cited by 63

Selective inhibition of EZH2 by a small molecule inhibitor regulates microglial gene expression essential for inflammation

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The Role of miRNA in Renal Fibrosis Leading to Chronic Kidney Disease

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Biflorin, Isolated from the Flower Buds ofSyzygium aromaticumL., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock

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Wnt/TLR Dialog in Neuroinflammation, Relevance in Alzheimer’s Disease

Zolezzi, J. M., & Inestrosa, N. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00187 · Cited by 50

β-Hydroxybutyrate suppresses M1 macrophage polarization through β-hydroxybutyrylation of the STAT1 protein

Bai, Y.-P., Xing, Y., Ma, T., Li, K., Zhang, T., Wang, D.-G., Wan, S., Zhang, C.-W., Sun, Y., Wang, M., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07268-3 · Cited by 47

Neuroinflammatory Triangle Presenting Novel Pharmacological Targets for Ischemic Brain Injury

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Genomic instability and innate immune responses to self-DNA in progeria

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Hepatitis B Virus–Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes

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Two Faces of Macrophages: Training and Tolerance

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Activation of the nuclear factor-κB pathway during postnatal lung inflammation preserves alveolarization by suppressing macrophage inflammatory protein-2

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Targeting STAT3 and NF-κB Signaling Pathways in Cancer Prevention and Treatment: The Role of Chalcones

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Reactive microglia and astrocytes in neonatal intraventricular hemorrhage model are blocked by mesenchymal stem cells

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MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1

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BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation

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Suppressing neutrophil itaconate production attenuates Mycoplasma pneumoniae pneumonia

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Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia

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Receptors That Inhibit Macrophage Activation: Mechanisms and Signals of Regulation and Tolerance

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Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR‐138‐5p‐Mediated EGR1/TLR4/TRIF Inactivation

Huang, C., Qu, Y., Feng, F., Zhang, H., Shu, L., Zhu, X., Huang, G., & Xu, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1927260 · Cited by 38

Cirsimarin, a flavone glucoside from the aerial part of Cirsium japonicum var. ussuriense (Regel) Kitam. ex Ohwi, suppresses the JAK/STAT and IRF-3 signaling pathway in LPS-stimulated RAW 264.7 macrophages

Han, H.-S., Shin, J., Lee, S.-B., Park, J. C., & Lee, K. (2018) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.07.024 · Cited by 37

STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria

Chen, T., Tsai, M.-H., Kung, J. T., Lin, K., Decker, T., & Lee, C. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151620 · Cited by 37

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

Cohen‐Katsenelson, K., Stender, J. D., Kawashima, A. T., Lordén, G., Uchiyama, S., Nizet, V., Glass, C. K., & Newton, A. C. (2019) · eLife · doi:10.7554/elife.48609 · Cited by 33

Metformin and 4SC‐202 synergistically promote intrinsic cell apoptosis by accelerating ΔNp63 ubiquitination and degradation in oral squamous cell carcinoma

He, Y., Tai, S., Deng, M., Fan, Z., Ping, F., He, L., Zhang, C., Huang, Y., Cheng, B., & Xia, J. (2019) · Cancer Medicine · doi:10.1002/cam4.2206 · Cited by 32

Molecular profiling of regulatory T cells in pulmonary sarcoidosis

Kachamakova‐Trojanowska, N., Jaźwa, A., Szade, K., Kasper, Ł., Soja, J., Andrychiewicz, A., Jakieła, B., Plutecka, H., Sanak, M., Józkowicz, A., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.07.012 · Cited by 32

Inhibition of human macrophage activation via pregnane neurosteroid interactions with toll-like receptors: Sex differences and structural requirements

Balan, I. S., Aurelian, L., Williams, K. S., Campbell, B., Meeker, R. B., & Morrow, A. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940095 · Cited by 33

Tumor-associated macrophages promote invasion via Toll-like receptors signaling in patients with ovarian cancer

Xing, K., Zhang, S., Wu, M. C., Lou, J., Zhang, J., Xu, T., Huang, L., Huang, P., Wang, F., & Pan, S. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.08.029 · Cited by 32

The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

Salgado, R. C., Fonseca, D. L. M., Marques, A. H. C., da Silva Napoleao, S. M., França, T. T., Akashi, K. T., de Souza Prado, C. A., Baiocchi, G. C., Plaça, D. R., Jansen-Marques, G., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-99838-0 · Cited by 14

Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana

Fernández-Figueroa, E. A., Imaz-Rosshandler, I., Fernandez, J. C., Miranda-Ortíz, H., Fernández-López, J. C., Becker, I., & Rangel‐Escareño, C. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004570 · Cited by 31

Patriscabrin F from the roots of Patrinia scabra attenuates LPS-induced inflammation by downregulating NF-κB, AP-1, IRF3, and STAT1/3 activation in RAW 264.7 macrophages

Shin, J., Kang, S., Lee, H., Kim, S.-Y., Lee, D. H., Jang, D. S., & Lee, K. (2020) · Phytomedicine · doi:10.1016/j.phymed.2019.153167 · Cited by 30

Emerging evidence for endogenous neurosteroid modulation of pro-inflammatory and anti-inflammatory pathways that impact neuropsychiatric disease

Morrow, A. L., Boero, G., & Balan, I. S. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105558 · Cited by 31

STAT1a and STAT1b of black carp play important roles in the innate immune defense against GCRV

Wu, H., Zhang, Y., Lu, X., Xiao, J., Feng, P., & Feng, H. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.01.037 · Cited by 29

Oxidative Stress Inhibits Endotoxin Tolerance and May Affect Periodontitis

Yamaguchi, T., Yamamoto, Y., Egashira, K., Satô, A., Kondo, Y., Saiki, S., Kimura, M., Chikazawa, T., Yamamoto, Y., Ishigami, A., et al. (2022) · Journal of Dental Research · doi:10.1177/00220345221138523 · Cited by 28

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses

Metwally, H., Elbrashy, M. M., Ozawa, T., Okuyama, K., White, J. T., Tulyeu, J., Søndergaard, J. N., Wing, J. B., Muratsu, A., Matsumoto, H., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402226121 · Cited by 27

Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block

Clancy, R. M., Markham, A. J., Reed, J. H., Blumenberg, M., Halushka, M. K., & Buyon, J. P. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.09.003 · Cited by 27

Suppression of Neutrophil Antimicrobial Functions by Total Particulate Matter From Cigarette Smoke

Zhang, Y., Geng, S., Prasad, G. L., & Li, L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02274 · Cited by 26

Alpinia officinarum water extract inhibits the atopic dermatitis-like responses in NC/Nga mice by regulation of inflammatory chemokine production

Song, H., Park, S. H., Kim, H. J., Jang, S., & Kim, T. S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112322 · Cited by 26

Anti-Inflammatory Effect of 3-Bromo-4,5-Dihydroxybenzaldehyde, a Component ofPolysiphonia morrowii,In VivoandIn Vitro

Kang, N.-J., Han, S.-C., Kang, H.-J., Ko, G., Yoon, W., Kang, H., & Yoo, E.-S. (2017) · Toxicological Research · doi:10.5487/tr.2017.33.4.325 · Cited by 26

Zinc Modulates Several Transcription-Factor Regulated Pathways in Mouse Skeletal Muscle Cells

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Quercetin Efficiently Alleviates TNF-α-Stimulated Injury by Signal Transducer and Activator of Transcription 1 and Mitogen-Activated Protein Kinase Pathway in H9c2 Cells: A Protective Role of Quercetin in Myocarditis

Yang, B., Zheng, C., Zhang, R., Zhao, C., Li, S., & An, Y. (2021) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001000 · Cited by 26

Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development

Chodisetti, S. B., Fike, A. J., Domeier, P. P., Schell, S. L., Mockus, T. E., Choi, N. M., Corradetti, C., Hou, B., Atkins, H., Caricchio, R., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000170 · Cited by 24

4-Phenylbutyrate Benefits Traumatic Hemorrhagic Shock in Rats by Attenuating Oxidative Stress, Not by Attenuating Endoplasmic Reticulum Stress

Yang, G., Peng, X., Hu, Y., Lan, D., Wu, Y., Li, T., & Liu, L. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001469 · Cited by 23

Regulation of PHLDA1 Expression by JAK2-ERK1/2-STAT3 Signaling Pathway

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Modulation of experimental acute lung injury by exosomal miR-7704 from mesenchymal stromal cells acts through M2 macrophage polarization

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Grouper STAT1a is involved in antiviral immune response against iridovirus and nodavirus infection

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