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The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response

Salgado, Ranieri Coelho, Fonseca, Dennyson Leandro M., Marques, Alexandre H. C., da Silva Napoleao, Sarah Maria, França, Tábata Takahashi, Akashi, Karen Tiemi, de Souza Prado, Caroline Aliane, Baiocchi, Gabriela Crispim, Plaça, Desirée Rodrigues, Jansen-Marques, Gabriel, Filgueiras, Igor Salerno, De Vito, Roberta, Freire, Paula Paccielli, de Miranda, Gustavo Cabral, Camara, Niels Olsen Saraiva, Calich, Vera Lúcia Garcia, Ochs, Hans D., Schimke, Lena F., Jurisica, Igor, Condino-Neto, Antonio, Cabral-Marques, Otavio·2021·Scientific Reports
DOI 10.1038/s41598-021-99838-0
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Abstract

Fungal infections represent a major global health problem affecting over a billion people that kills more than 1.5 million annually. In this study, we employed an integrative approach to reveal the landscape of the human immune responses to Candida spp.through meta-analysis of microarray, bulk, and single-cell RNA sequencing (scRNA-seq) data for the blood transcriptome. We identified across these different studies a consistent interconnected network interplay of signaling molecules involved in both Toll-like receptor (TLR) and interferon (IFN) signaling cascades that is activated in response to different Candida species (C. albicans,C. auris,C. glabrata,C. parapsilosis, and C. tropicalis). Among these molecules are several types I IFN, indicating an overlap with antiviral immune responses. scRNA-seq data confirmed that genes commonly identified by the three transcriptomic methods show cell type-specific expression patterns in various innate and adaptive immune cells. These findings shed new light on the anti-Candida immune response, providing putative molecular pathways for therapeutic intervention.

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Metadata

Authors
Salgado, R. C., Fonseca, D. L. M., Marques, A. H. C., da Silva Napoleao, S. M., França, T. T., Akashi, K. T., de Souza Prado, C. A., Baiocchi, G. C., Plaça, D. R., Jansen-Marques, G., Filgueiras, I. S., De Vito, R., Freire, P. P., de Miranda, G. C., Camara, N. O. S., Calich, V. L. G., Ochs, H. D., Schimke, L. F., Jurisica, I., Condino-Neto, A., & Cabral-Marques, O.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2021-10-13
Volume
11
Issue
1
ISSN
2045-2322
DOI
10.1038/s41598-021-99838-0
Cited by
14
References
11
Language
en
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CoChat. (2026). Citation check: The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response. https://app.cochat.ai/papers/10.1038/s41598-021-99838-0
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Salgado, R. C., Fonseca, D. L. M., Marques, A. H. C., da Silva Napoleao, S. M., França, T. T., Akashi, K. T., de Souza Prado, C. A., Baiocchi, G. C., Plaça, D. R., Jansen-Marques, G., Filgueiras, I. S., De Vito, R., Freire, P. P., de Miranda, G. C., Camara, N. O. S., Calich, V. L. G., Ochs, H. D., Schimke, L. F., Jurisica, I., . . . Cabral-Marques, O. (2021). The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response. Scientific Reports. https://doi.org/10.1038/s41598-021-99838-0