The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip
Abstract
Our intention was to examine if subnormal testosterone levels in older men were associated with a reduction in quality of life and physical and mental health, and secondly to examine if testosterone treatment could improve these conditions. We performed a nested case-control study and a 1-year testosterone intervention study. Men with subnormal testosterone had significantly higher weight, fat mass and abdominal adipose tissue. They also had significantly higher glucose and insulin levels, and they had higher triglyceride levels. Testosterone treatment had a large impact on body composition with reduced fat mass and abdominal adipose tissue and increased fat-free mass, but it did not affect weight and glucose and lipid metabolism. Bone mineral density in the hip was significantly higher after the testosterone treatment. Older men with subnormal testosterone levels had an unfavorable metabolic profile. Testosterone treatment improved body composition, but it did not reverse the unfavorable metabolic profile.
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“For example, it has been observed in elderly (60-80 year-old) men with subnormal T levels that subcutaneous and visceral fat mass are elevated when compared to elderly men with normal T levels.71”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [71]
In the citing paper
“In elderly men, lower T levels are associated with reduced insulin sensitivity as indicated by higher glucose levels during an oral glucose tolerance test,71 reduced quantitative insulin sensitivity check index score,93, 94 and lower HOMA-IR values.95”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [71]
In the citing paper
“In studies using intramuscular testosterone undecanoate, reductions in fat mass ranged from 3.4 kg 81 to 4.2 kg, 93”
From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [93]
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Items 101–159 of 159
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Metadata
- Authors
- Svartberg, J., Agledahl, I., Figenschau, Y., Sildnes, T., Waterloo, K., & Jorde, R.
- Affiliations
- University Hospital of North Norway (NO)
- Corresponding author
- Svartberg, J
- ORCID
- Venue
- International Journal of Impotence Research
- Published
- 2008-05-15
- Volume
- 20
- Issue
- 4
- Pages
- 378-387
- ISSN
- 0955-9930 (ISSN-L)
- 1476-5489
- OpenAlex
- W2023325491
- Cited by
- 160
- References
- 33
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 13 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 15 · 2012: 9
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Impotence Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- testosterone replacement therapy, hypogonadism, older men, body composition, bone mineral density, hip bone, fat mass, abdominal fat, fat-free mass, insulin, glucose, triglycerides, lipid metabolism, quality of life, metabolic profile
- MeSH terms
- Aged, Aged, 80 and over, Body Composition, Disease, Glucose, Hip, Humans, Male, Middle Aged, Muscles, Quality of Life, Testosterone, Bone Density, Case-Control Studies, Lipid Metabolism
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