Cited by 160Hormonal and reproductive studiesNutrition and Health in AgingMenopause: Health Impacts and Treatments

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Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip

Svartberg, J, Agledahl, I, Figenschau, Y, Sildnes, T, Waterloo, K, Jorde, R·2008·International Journal of Impotence Research

DOI 10.1038/ijir.2008.19

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Abstract

Our intention was to examine if subnormal testosterone levels in older men were associated with a reduction in quality of life and physical and mental health, and secondly to examine if testosterone treatment could improve these conditions. We performed a nested case-control study and a 1-year testosterone intervention study. Men with subnormal testosterone had significantly higher weight, fat mass and abdominal adipose tissue. They also had significantly higher glucose and insulin levels, and they had higher triglyceride levels. Testosterone treatment had a large impact on body composition with reduced fat mass and abdominal adipose tissue and increased fat-free mass, but it did not affect weight and glucose and lipid metabolism. Bone mineral density in the hip was significantly higher after the testosterone treatment. Older men with subnormal testosterone levels had an unfavorable metabolic profile. Testosterone treatment improved body composition, but it did not reverse the unfavorable metabolic profile.

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Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
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Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
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Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861
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Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., L'Italien, G. J., Pio, J. R., & Williams, G. R. (2004) · Circulation · doi:10.1161/01.cir.0000140677.20606.0e · Cited by 1,837
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Carani, C., Qin, K., Simoni, M., Faustini-Fustini, M., Serpente, S., Boyd, J., Korach, K. S., & Simpson, E. R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707103370204 · Cited by 1,151
Age, Disease, and Changing Sex Hormone Levels in Middle-Aged Men: Results of the Massachusetts Male Aging Study*
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2847 · Cited by 965
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Sih, R., Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., & Ross, C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.3988 · Cited by 920
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Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., Salonen, R., & Salonen, J. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1036 · Cited by 920

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Authors: Svartberg, J., Agledahl, I., Figenschau, Y., Sildnes, T., Waterloo, K., & Jorde, R.
Affiliations: University Hospital of North Norway (NO)
Corresponding author: Svartberg, J
ORCID: Waterloo, K
Jorde, R
Venue: International Journal of Impotence Research
Publisher: Springer Science and Business Media LLC
Published: 2008-05-15
Volume: 20
Issue: 4
Pages: 378-387
ISSN: 0955-9930 (ISSN-L)
1476-5489
DOI: 10.1038/ijir.2008.19
OpenAlex: W2023325491
Cited by: 160
References: 33
Citations by year: 2026: 2 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 13 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 15 · 2012: 9
FWCI: 6.77
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: International Journal of Impotence Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone replacement therapy, hypogonadism, older men, body composition, bone mineral density, hip bone, fat mass, abdominal fat, fat-free mass, insulin, glucose, triglycerides, lipid metabolism, quality of life, metabolic profile
MeSH terms: Aged, Aged, 80 and over, Body Composition, Disease, Glucose, Hip, Humans, Male, Middle Aged, Muscles, Quality of Life, Testosterone, Bone Density, Case-Control Studies, Lipid Metabolism

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Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip

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